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Osteoblast-derived ...
Osteoblast-derived WNT16 represses osteoclastogenesis and prevents cortical bone fragility fractures.
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- Movérare-Skrtic, Sofia (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Centre for Bone and Arthritis Research,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition,University of Gothenburg,Sahlgrenska Academy at University of Gothenburg, Sweden
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- Henning, Petra, 1974 (author)
- Gothenburg University,Göteborgs universitet,Centre for Bone and Arthritis Research,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition,University of Gothenburg,Sahlgrenska Academy at University of Gothenburg, Sweden
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- Liu, Xianwen (author)
- West China Hospital,Southern Medical University,Harvard School of Dental Medicine, Boston, Massachusetts, USA; Sichuan University, China
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- Nagano, Kenichi (author)
- Harvard School of Dental Medicine, Boston, Massachusetts, USA
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- Saito, Hiroaki (author)
- Universitatsklinikum Hamburg-Eppendorf und Medizinische Fakultat,Harvard School of Dental Medicine, Boston, Massachusetts, USA
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- Börjesson, Anna E (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Centre for Bone and Arthritis Research,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition,University of Gothenburg,Sahlgrenska Academy at University of Gothenburg, Sweden
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- Sjögren, Klara, 1970 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Centre for Bone and Arthritis Research,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition,University of Gothenburg,Sahlgrenska Academy at University of Gothenburg, Sweden
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- Windahl, Sara H, 1971 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Centre for Bone and Arthritis Research,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition,University of Gothenburg,Sahlgrenska Academy at University of Gothenburg, Sweden
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- Farman, Helen H., 1983 (author)
- Karolinska Institutet,Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Centre for Bone and Arthritis Research,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition,University of Gothenburg,Sahlgrenska Academy at University of Gothenburg, Sweden
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- Kindlund, Bert, 1969 (author)
- Gothenburg University,Göteborgs universitet,Centre for Bone and Arthritis Research,Institutionen för medicin,Institute of Medicine,University of Gothenburg,Sahlgrenska Academy at University of Gothenburg, Sweden
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- Engdahl, Cecilia, 1983 (author)
- Gothenburg University,Göteborgs universitet,Centre for Bone and Arthritis Research,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research,University of Gothenburg,Sahlgrenska Academy at University of Gothenburg, Sweden
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- Koskela, Antti (author)
- Oulun Yliopisto,University of Oulu,University of Oulu, Finland
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- Zhang, Fu-Ping (author)
- Turun Yliopisto,University of Turku,University of Turku, Finland
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- Eriksson, Emma E (author)
- Karolinska Institutet,Karolinska Institutet, Pediatric Endocrinology Unit, Stockholm, Sweden
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- Zaman, Farasat (author)
- Karolinska Institutet,Karolinska Institutet, Pediatric Endocrinology Unit, Stockholm, Sweden
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- Hammarstedt, Ann, 1975 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine,University of Gothenburg,Sahlgrenska Academy at University of Gothenburg, Sweden
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- Isaksson, Hanna (author)
- Lund University,Lunds universitet,Avdelningen för Biomedicinsk teknik,Institutionen för biomedicinsk teknik,Institutioner vid LTH,Lunds Tekniska Högskola,Department of Biomedical Engineering,Departments at LTH,Faculty of Engineering, LTH,Lund University, Sweden
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- Bally, Marta, 1981 (author)
- Chalmers tekniska högskola,Chalmers University of Technology,Chalmers University of Technology, Gothenburg, Sweden.
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- Kassem, Ali (author)
- Umeå universitet,Institutionen för odontologi,Umeå University, Sweden
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- Lindholm, Catharina, 1967 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin,Institute of Medicine,University of Gothenburg,Sahlgrenska Academy at University of Gothenburg, Sweden
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- Sandberg, Olof (author)
- Linköpings universitet,Avdelningen för kliniska vetenskaper,Hälsouniversitetet
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- Aspenberg, Per (author)
- Östergötlands Läns Landsting,Linköpings universitet,Avdelningen för kliniska vetenskaper,Hälsouniversitetet,Ortopedkliniken i Linköping
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- Sävendahl, Lars (author)
- Karolinska Institutet
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- Feng, Jian Q (author)
- Texas A&M Health Science Center, Dallas, Texas, USA
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- Tuckermann, Jan (author)
- Universität Ulm,University of Ulm,University of Ulm, Germany
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- Tuukkanen, Juha (author)
- Oulun Yliopisto,University of Oulu,University of Oulu, Finland
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- Poutanen, Matti (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Centre for Bone and Arthritis Research,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition,University of Gothenburg,Sahlgrenska Academy at University of Gothenburg, Sweden
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- Baron, Roland (author)
- Massachusetts General Hospital,Harvard School of Dental Medicine, Boston, Massachusetts, USA; Harvard Medical School, Boston, Massachusetts, USA
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- Lerner, Ulf H (author)
- Umeå universitet,Gothenburg University,Göteborgs universitet,Centre for Bone and Arthritis Research,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition,University of Gothenburg,Institutionen för odontologi,Centre for Bone and Arthritis Research at Institute of Medicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden
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- Gori, Francesca (author)
- Massachusetts General Hospital,Harvard School of Dental Medicine, Boston, Massachusetts, USA; Harvard Medical School, Boston, Massachusetts, USA
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- Ohlsson, Claes, 1965 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Centre for Bone and Arthritis Research,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition,University of Gothenburg,Sahlgrenska Academy at University of Gothenburg, Sweden
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(creator_code:org_t)
- 2014-10-12
- 2014
- English.
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In: Nature Medicine. - : Springer Science and Business Media LLC. - 1078-8956 .- 1546-170X. ; 20:11, s. 1279-88
- Related links:
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http://dx.doi.org/10...
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Abstract
Subject headings
Close
- The WNT16 locus is a major determinant of cortical bone thickness and nonvertebral fracture risk in humans. The disability, mortality and costs caused by osteoporosis-induced nonvertebral fractures are enormous. We demonstrate here that Wnt16-deficient mice develop spontaneous fractures as a result of low cortical thickness and high cortical porosity. In contrast, trabecular bone volume is not altered in these mice. Mechanistic studies revealed that WNT16 is osteoblast derived and inhibits human and mouse osteoclastogenesis both directly by acting on osteoclast progenitors and indirectly by increasing expression of osteoprotegerin (Opg) in osteoblasts. The signaling pathway activated by WNT16 in osteoclast progenitors is noncanonical, whereas the pathway activated in osteoblasts is both canonical and noncanonical. Conditional Wnt16 inactivation revealed that osteoblast-lineage cells are the principal source of WNT16, and its targeted deletion in osteoblasts increases fracture susceptibility. Thus, osteoblast-derived WNT16 is a previously unreported key regulator of osteoclastogenesis and fracture susceptibility. These findings open new avenues for the specific prevention or treatment of nonvertebral fractures, a substantial unmet medical need.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
- TEKNIK OCH TEKNOLOGIER -- Medicinteknik (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Medical Engineering (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi -- Medicinsk bioteknologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology -- Medical Biotechnology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Movérare-Skrtic, ...
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Henning, Petra, ...
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Liu, Xianwen
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Nagano, Kenichi
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Saito, Hiroaki
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Börjesson, Anna ...
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show more...
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Sjögren, Klara, ...
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Windahl, Sara H, ...
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Farman, Helen H. ...
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Kindlund, Bert, ...
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Engdahl, Cecilia ...
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Koskela, Antti
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Zhang, Fu-Ping
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Eriksson, Emma E
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Zaman, Farasat
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Hammarstedt, Ann ...
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Isaksson, Hanna
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Bally, Marta, 19 ...
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Kassem, Ali
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Lindholm, Cathar ...
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Sandberg, Olof
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Aspenberg, Per
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Sävendahl, Lars
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Feng, Jian Q
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Tuckermann, Jan
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Tuukkanen, Juha
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Poutanen, Matti
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Baron, Roland
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Lerner, Ulf H
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Gori, Francesca
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Ohlsson, Claes, ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Endocrinology an ...
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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ENGINEERING AND ...
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and Medical Engineer ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
- Articles in the publication
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Nature Medicine
- By the university
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University of Gothenburg
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Chalmers University of Technology
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Lund University
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Umeå University
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Linköping University
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Karolinska Institutet