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hsv:(TEKNIK OCH TEKNOLOGIER) hsv:(Medicinteknik)
 

Search: hsv:(TEKNIK OCH TEKNOLOGIER) hsv:(Medicinteknik) > Medical and Health Sciences > Osteoblast-derived ...

Osteoblast-derived WNT16 represses osteoclastogenesis and prevents cortical bone fragility fractures.

Movérare-Skrtic, Sofia (author)
Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Centre for Bone and Arthritis Research,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition,University of Gothenburg,Sahlgrenska Academy at University of Gothenburg, Sweden
Henning, Petra, 1974 (author)
Gothenburg University,Göteborgs universitet,Centre for Bone and Arthritis Research,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition,University of Gothenburg,Sahlgrenska Academy at University of Gothenburg, Sweden
Liu, Xianwen (author)
West China Hospital,Southern Medical University,Harvard School of Dental Medicine, Boston, Massachusetts, USA; Sichuan University, China
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Nagano, Kenichi (author)
Harvard School of Dental Medicine, Boston, Massachusetts, USA
Saito, Hiroaki (author)
Universitatsklinikum Hamburg-Eppendorf und Medizinische Fakultat,Harvard School of Dental Medicine, Boston, Massachusetts, USA
Börjesson, Anna E (author)
Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Centre for Bone and Arthritis Research,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition,University of Gothenburg,Sahlgrenska Academy at University of Gothenburg, Sweden
Sjögren, Klara, 1970 (author)
Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Centre for Bone and Arthritis Research,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition,University of Gothenburg,Sahlgrenska Academy at University of Gothenburg, Sweden
Windahl, Sara H, 1971 (author)
Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Centre for Bone and Arthritis Research,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition,University of Gothenburg,Sahlgrenska Academy at University of Gothenburg, Sweden
Farman, Helen H., 1983 (author)
Karolinska Institutet,Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Centre for Bone and Arthritis Research,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition,University of Gothenburg,Sahlgrenska Academy at University of Gothenburg, Sweden
Kindlund, Bert, 1969 (author)
Gothenburg University,Göteborgs universitet,Centre for Bone and Arthritis Research,Institutionen för medicin,Institute of Medicine,University of Gothenburg,Sahlgrenska Academy at University of Gothenburg, Sweden
Engdahl, Cecilia, 1983 (author)
Gothenburg University,Göteborgs universitet,Centre for Bone and Arthritis Research,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research,University of Gothenburg,Sahlgrenska Academy at University of Gothenburg, Sweden
Koskela, Antti (author)
Oulun Yliopisto,University of Oulu,University of Oulu, Finland
Zhang, Fu-Ping (author)
Turun Yliopisto,University of Turku,University of Turku, Finland
Eriksson, Emma E (author)
Karolinska Institutet,Karolinska Institutet, Pediatric Endocrinology Unit, Stockholm, Sweden
Zaman, Farasat (author)
Karolinska Institutet,Karolinska Institutet, Pediatric Endocrinology Unit, Stockholm, Sweden
Hammarstedt, Ann, 1975 (author)
Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine,University of Gothenburg,Sahlgrenska Academy at University of Gothenburg, Sweden
Isaksson, Hanna (author)
Lund University,Lunds universitet,Avdelningen för Biomedicinsk teknik,Institutionen för biomedicinsk teknik,Institutioner vid LTH,Lunds Tekniska Högskola,Department of Biomedical Engineering,Departments at LTH,Faculty of Engineering, LTH,Lund University, Sweden
Bally, Marta, 1981 (author)
Chalmers tekniska högskola,Chalmers University of Technology,Chalmers University of Technology, Gothenburg, Sweden.
Kassem, Ali (author)
Umeå universitet,Institutionen för odontologi,Umeå University, Sweden
Lindholm, Catharina, 1967 (author)
Gothenburg University,Göteborgs universitet,Institutionen för medicin,Institute of Medicine,University of Gothenburg,Sahlgrenska Academy at University of Gothenburg, Sweden
Sandberg, Olof (author)
Linköpings universitet,Avdelningen för kliniska vetenskaper,Hälsouniversitetet
Aspenberg, Per (author)
Östergötlands Läns Landsting,Linköpings universitet,Avdelningen för kliniska vetenskaper,Hälsouniversitetet,Ortopedkliniken i Linköping
Sävendahl, Lars (author)
Karolinska Institutet
Feng, Jian Q (author)
Texas A&M Health Science Center, Dallas, Texas, USA
Tuckermann, Jan (author)
Universität Ulm,University of Ulm,University of Ulm, Germany
Tuukkanen, Juha (author)
Oulun Yliopisto,University of Oulu,University of Oulu, Finland
Poutanen, Matti (author)
Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Centre for Bone and Arthritis Research,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition,University of Gothenburg,Sahlgrenska Academy at University of Gothenburg, Sweden
Baron, Roland (author)
Massachusetts General Hospital,Harvard School of Dental Medicine, Boston, Massachusetts, USA; Harvard Medical School, Boston, Massachusetts, USA
Lerner, Ulf H (author)
Umeå universitet,Gothenburg University,Göteborgs universitet,Centre for Bone and Arthritis Research,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition,University of Gothenburg,Institutionen för odontologi,Centre for Bone and Arthritis Research at Institute of Medicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden
Gori, Francesca (author)
Massachusetts General Hospital,Harvard School of Dental Medicine, Boston, Massachusetts, USA; Harvard Medical School, Boston, Massachusetts, USA
Ohlsson, Claes, 1965 (author)
Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Centre for Bone and Arthritis Research,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition,University of Gothenburg,Sahlgrenska Academy at University of Gothenburg, Sweden
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 (creator_code:org_t)
2014-10-12
2014
English.
In: Nature Medicine. - : Springer Science and Business Media LLC. - 1078-8956 .- 1546-170X. ; 20:11, s. 1279-88
  • Journal article (peer-reviewed)
Abstract Subject headings
Close  
  • The WNT16 locus is a major determinant of cortical bone thickness and nonvertebral fracture risk in humans. The disability, mortality and costs caused by osteoporosis-induced nonvertebral fractures are enormous. We demonstrate here that Wnt16-deficient mice develop spontaneous fractures as a result of low cortical thickness and high cortical porosity. In contrast, trabecular bone volume is not altered in these mice. Mechanistic studies revealed that WNT16 is osteoblast derived and inhibits human and mouse osteoclastogenesis both directly by acting on osteoclast progenitors and indirectly by increasing expression of osteoprotegerin (Opg) in osteoblasts. The signaling pathway activated by WNT16 in osteoclast progenitors is noncanonical, whereas the pathway activated in osteoblasts is both canonical and noncanonical. Conditional Wnt16 inactivation revealed that osteoblast-lineage cells are the principal source of WNT16, and its targeted deletion in osteoblasts increases fracture susceptibility. Thus, osteoblast-derived WNT16 is a previously unreported key regulator of osteoclastogenesis and fracture susceptibility. These findings open new avenues for the specific prevention or treatment of nonvertebral fractures, a substantial unmet medical need.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine (hsv//eng)
TEKNIK OCH TEKNOLOGIER  -- Medicinteknik (hsv//swe)
ENGINEERING AND TECHNOLOGY  -- Medical Engineering (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Medicinsk bioteknologi -- Medicinsk bioteknologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Medical Biotechnology -- Medical Biotechnology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine (hsv//eng)

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