SwePub
Sök i LIBRIS databas

  Utökad sökning

onr:"swepub:oai:DiVA.org:uu-181434"
 

Sökning: onr:"swepub:oai:DiVA.org:uu-181434" > Outcome differences...

Outcome differences between debulking surgery and cytoreductive surgery in patients with pseudomyxoma peritonei

Andréasson, Håkan, (författare)
Uppsala universitet, Kolorektalkirurgi
Graf, Wilhelm, (författare)
Uppsala universitet, Kolorektalkirurgi
Nygren, Peter, (författare)
Uppsala universitet, Enheten för onkologi
visa fler...
Glimelius, Bengt, (författare)
Uppsala universitet, Enheten för onkologi
Mahteme, Haile, (författare)
Uppsala universitet, Kolorektalkirurgi
visa färre...
2012
Engelska.
Ingår i: European Journal of Surgical Oncology. - 0748-7983 .- 1532-2157. ; 38:10, s. 962-968
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • <p><strong>BACKGROUND:</strong></p><p>The aim of this study was to compare debulking surgery and cytoreductive surgery (CRS) in patients with Pseudomyxoma peritonei (PMP) regarding efficacy and safety.</p><p><strong>PATIENTS AND METHODS:</strong></p><p>Data were extracted from medical records and treatment outcomes were analyzed for all 152 patients with PMP who were scheduled for debulking surgery and intraperitoneal chemotherapy (IPC) or CRS and IPC at Uppsala University Hospital, Uppsala, Sweden, between September 1993 and December 2008.</p><p><strong>RESULTS:</strong></p><p>One hundred and ten patients (73%) were treated with CRS and IPC and 40 (27%) with debulking surgery and IPC. In two patients (1%), surgery was defined as open and close. Patients with CRS and IPC had a 74% 5-year overall survival (OS) rate compared with 40% for those treated with debulking surgery (P &lt; 0.001). Patients with no residual macroscopic tumour (R1 resection) had a better 5-year OS rate of 94% compared with 28% for patients with macroscopic residual tumour (R2) (P &lt; 0.001). Grades II-IV adverse events were seen in 29% of debulked patients and in 47% of CRS/IPC patients (P = 0.053).</p><p><strong>CONCLUSIONS:</strong></p><p>CRS and IPC seems more efficient than debulking surgery and IPC but with numerically higher morbidity. Therefore, if surgically possible, CRS should be the treatment of choice for PMP patients. However, debulking surgery may still be of benefit to selected patients for palliative purposes.</p>

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  (hsv//swe)
MEDICAL AND HEALTH SCIENCES  (hsv//eng)

Publikations- och innehållstyp

ref (ämneskategori)
art (ämneskategori)
ref (ämneskategori)

Hitta via bibliotek

Till lärosätets databas

Sök utanför SwePub

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy