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Effects of DPP-4 in...
Effects of DPP-4 inhibitor linagliptin and GLP-1 receptor agonist liraglutide on physiological response to hypoglycaemia in Japanese subjects with type 2 diabetes : A randomized, open-label, 2-arm parallel comparative, exploratory trial
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- Yabe, Daisuke (author)
- Kobe university
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- Eto, Takashi (author)
- Hakata Clinic
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- Shiramoto, Masanari (author)
- Hakata Clinic
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- Irie, Shin (author)
- Hakata Clinic
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- Murotani, Kenta (author)
- Aichi Medical University
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- Seino, Yusuke (author)
- Nagoya University
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- Kuwata, Hitoshi (author)
- Kansai Electric Power Medical Research Institute (KEPMRI)
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- Kurose, Takeshi (author)
- Kansai Electric Power Medical Research Institute (KEPMRI)
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- Seino, Susumu (author)
- Kobe university
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- Ahrén, Bo (author)
- Lund University,Lunds universitet,Medicin/akutsjukvård, Lund,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Medicine, Lund,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Seino, Yutaka (author)
- Kansai Electric Power Medical Research Institute (KEPMRI)
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(creator_code:org_t)
- 2016-11-29
- 2017
- English.
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In: Diabetes, Obesity and Metabolism. - : Wiley. - 1462-8902. ; 19:3, s. 442-447
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Abstract
Subject headings
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- Dipeptidyl peptidase-4 (DPP-4) inhibitors reduce the risk of hypoglycaemia, possibly through augmentation of glucose-dependent insulinotropic polypeptide (GIP) action, but not that of glucagon-like peptide-1 (GLP-1) on glucagon secretion. To examine this model in Japanese individuals with type 2 diabetes (T2D), the effects of the DPP-4 inhibitor linagliptin on glucagon and other counter-regulatory hormone responses to hypoglycaemia were evaluated and compared with those of the GLP-1 receptor agonist liraglutide in a multi-centre, randomized, open-label, 2-arm parallel comparative, exploratory trial. Three-step hypoglycaemic clamp glucose tests preceded by meal tolerance tests were performed before and after 2-week treatment with the drugs. Glucagon levels were increased during the hypoglycaemic clamp test at 2.5mmol/L. This increase was similar in the linagliptin and liraglutide groups, both before and after the 2-week treatment. Changes in other counter-regulatory hormones (ie, growth hormone, cortisol, epinephrine and norepinephrine) were also similar between the groups, but were suppressed substantially after 2-week treatment compared to baseline. In conclusion, we confirmed that the glucagon response to hypoglycaemia was not affected by linagliptin or liraglutide treatment in Japanese individuals with T2D.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Keyword
- GLP-1 receptor agonist
- DPP-4 inhibitor
- Glucagon response
- Hypoglycaemia
- Sympatho-adrenal response
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Yabe, Daisuke
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Eto, Takashi
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Shiramoto, Masan ...
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Irie, Shin
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Murotani, Kenta
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Seino, Yusuke
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show more...
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Kuwata, Hitoshi
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Kurose, Takeshi
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Seino, Susumu
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Ahrén, Bo
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Seino, Yutaka
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Endocrinology an ...
- Articles in the publication
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Diabetes, Obesit ...
- By the university
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Lund University