This paper inquires into the various forms of healing performed today among the Miskitu people of the Caribbean coast of Nicaragua. The Miskitu have a long history of relations with outsiders and with people of African origin. Miskitu cosmology and its ideas about illness and healing is today a mixture of indigenous, Afro-Caribbean, and Christian beliefs. Local healers constantly pick up new healing methods and ideas from other religious traditions in Central America, Mexico, and the Caribbean. The paper discusses how Miskitu healers, known as curanderos, sukias, and profetas, heal by relating sickness and suffering to a world of spirits which also makes reference to the plural cultural antecedences of contemporary Miskitu worldview.