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Vascular oxygen con...
Vascular oxygen content and the tissue oxygenation--a theoretical analysis.
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- Dasu, Alexandru (author)
- Umeå universitet,Radiofysik,Norrland University Hospital, Sweden
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- Toma-Dasu, Iuliana (author)
- Stockholms universitet,Medicinsk strålningsfysik (tills m KI),Stockholm University and Karolinska Institutet
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Toma-Dasu, L (author)
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(creator_code:org_t)
- American Association of Physicists in Medicine (AAPM), 2008
- 2008
- English.
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In: Med Phys. - : American Association of Physicists in Medicine (AAPM). - 0094-2405. ; 35:2, s. 539-45
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Abstract
Subject headings
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- Several methods exist for evaluating tumor oxygenation as hypoxia is an important prognostic factor for cancer patients. They use different measuring principles that highlight various aspects of oxygenation. The results could be empirically correlated, but it has been suspected that there could be discordances in some cases. This study describes an analysis of the relationship between vascular and tissue oxygenations. Theoretical simulation has been employed to characterize tissue oxygenations for a broad range of distributions of intervessel distances and vascular oxygenations. The results were evaluated with respect to the implications for practical measurements of tissue oxygenations. The findings showed that although the tissue oxygenation is deterministically related to vascular oxygenation, the relationship between them is not unequivocal. Variability also exists between the fractions of values below the sensitivity thresholds of various measurement methods which in turn could be reflected in the power of correlations between results from different methods or in the selection of patients for prognostic studies. The study has also identified potential difficulties that may be encountered at the quantitative evaluation of the results from oxygenation measurements. These could improve the understanding of oxygenation measurements and the interpretation of comparisons between results from various measurement methods.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- Animals
- Blood Vessels/*metabolism
- Computer Simulation
- Humans
- Models; Biological
- Neoplasms/*blood supply/*metabolism
- Neovascularization; Pathologic/*metabolism
- Oxygen/*metabolism
- Oxygen Consumption
Publication and Content Type
- vet (subject category)
- art (subject category)
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