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Sex steroid-related...
Sex steroid-related genes and male-to-female transsexualism
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- Henningsson, Susanne, 1977 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för fysiologi och farmakologi, Avdelningen för farmakologi,Institute of Physiology and Pharmacology, Dept of Pharmacology,University of Gothenburg
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- Westberg, Lars, 1973 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för fysiologi och farmakologi, Avdelningen för farmakologi,Institute of Physiology and Pharmacology, Dept of Pharmacology,University of Gothenburg
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- Nilsson, Staffan, 1956 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för matematiska vetenskaper, matematisk statistik,Department of Mathematical Sciences, Mathematical Statistics,University of Gothenburg,Chalmers tekniska högskola,Chalmers University of Technology
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- Lundström, Bengt (author)
- Göteborgs universitet,University of Gothenburg
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- Ekselius, L (author)
- Uppsala universitet,Institutionen för neurovetenskap,psykiatri, UAS
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- Bodlund, Owe (author)
- Umeå universitet,Psykiatri,Umeå University
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- Lindström, Eva (author)
- Uppsala universitet,Uppsala University
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- Hellstrand, Monika, 1955 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för fysiologi och farmakologi, Avdelningen för farmakologi,Institute of Physiology and Pharmacology, Dept of Pharmacology,University of Gothenburg
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- Rosmond, Roland, 1966 (author)
- Gothenburg University,Göteborgs universitet,Hjärt-kärlinstitutionen,Cardiovascular Institute,University of Gothenburg
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- Eriksson, Elias, 1956 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för fysiologi och farmakologi, Avdelningen för farmakologi,Institute of Physiology and Pharmacology, Dept of Pharmacology,University of Gothenburg
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- Landén, Mikael, 1966 (author)
- Karolinska Institutet
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Lindström, L (author)
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(creator_code:org_t)
- Oxford : Pergamon Press, 2005
- 2005
- English.
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In: Psychoneuroendocrinology. - Oxford : Pergamon Press. - 0306-4530 .- 1873-3360. ; 59:5, s. 412-412
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Abstract
Subject headings
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- Transsexualism is characterised by Lifelong discomfort with the assigned sex and a strong identification with the opposite sex. The cause of transsexualism is unknown, but it has been suggested that an aberration in the early sexual differentiation of various brain structures may be involved. Animal experiments have revealed that the sexual differentiation of the brain is mainly due to an influence of testosterone, acting both via androgen receptors (ARs) and-after aromatase-catalyzed conversion to estradiol-via estrogen receptors (ERs). The present study examined the possible importance of three polymorphisms and their pairwise interactions for the development of male-to-female transsexualism: a CAG repeat sequence in the first exon of the AR gene, a tetra nucleotide repeat polymorphism in intron 4 of the aromatase gene, and a CA repeat polymorphism in intron 5 of the ER beta gene. Subjects were 29 Caucasian male-to-female transsexuals and 229 healthy mate controls. Transsexuals differed from controls with respect to the mean Length of the ER repeat polymorphism, but not with respect to the length of the other two studied polymorphisms. However, binary logistic regression analysis revealed significant partial effects for all three polymorphisms, as well as for the interaction between the AR and aromatase gene polymorphisms, on the risk of developing transsexualism. Given the small number of transsexuals in the study, the results should be interpreted with the utmost caution. Further study of the putative role of these and other sex steroid-related genes for the development of transsexualism may, however, be worthwhile.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
Keyword
- aromatase
- androgen receptor
- estrogen receptor beta
- gender identity disorder
- polymorphisms
- sexual differentiation
- transsexualism
- Aromatase; Androgen receptor; Estrogen receptor beta; Gender identity disorder; Polymorphisms; Sexual differentiation; Transsexualism
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Henningsson, Sus ...
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Westberg, Lars, ...
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Nilsson, Staffan ...
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Lundström, Bengt
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Ekselius, L
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Bodlund, Owe
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Lindström, Eva
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Hellstrand, Moni ...
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Rosmond, Roland, ...
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Eriksson, Elias, ...
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Landén, Mikael, ...
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Lindström, L
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Endocrinology an ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Psychiatry
- Articles in the publication
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Psychoneuroendoc ...
- Psychoneuroendoc ...
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NORDIC JOURNAL O ...
- By the university
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Umeå University
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University of Gothenburg
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Chalmers University of Technology
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Karolinska Institutet
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Uppsala University