Cell transcriptomic atlas of the non-human primate Macaca fascicularis

• Studying tissue composition and function in non-human primates (NHPs) is crucial to understand the nature of our own species. Here we present a large-scale cell transcriptomic atlas that encompasses over 1 million cells from 45 tissues of the adult NHP Macaca fascicularis. This dataset provides a vast annotated resource to study a species phylogenetically close to humans. To demonstrate the utility of the atlas, we have reconstructed the cell–cell interaction networks that drive Wnt signalling across the body, mapped the distribution of receptors and co-receptors for viruses causing human infectious diseases, and intersected our data with human genetic disease orthologues to establish potential clinical associations. Our M. fascicularis cell atlas constitutes an essential reference for future studies in humans and NHPs. 

Ämnesord

NATURVETENSKAP  -- Kemi -- Biokemi (hsv//swe)

NATURAL SCIENCES  -- Chemical Sciences -- Biochemistry (hsv//eng)

NATURVETENSKAP  -- Biologi -- Molekylärbiologi (hsv//swe)

NATURAL SCIENCES  -- Biological Sciences -- Molecular Biology (hsv//eng)

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)

Nyckelord

Wnt protein

transcriptome

cell

genetic analysis

phylogenetics

primate

adult

animal cell

animal experiment

animal tissue

Article

cell interaction

cell isolation

cell transcriptomic atlas

cellular

subcellular and molecular biological phenomena and functions

controlled study

female

genetic disorder

Macaca fascicularis

male

mouse

nonhuman

phylogeny

RNA sequencing

single cell RNA seq

single nucleus RNA sequencing

species comparison

virus infection

Wnt signaling

animal

genetics

virus

Animals

Primates

Viruses

Publikations- och innehållstyp

ref (ämneskategori)

art (ämneskategori)