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Sökning: onr:"swepub:oai:DiVA.org:liu-28548" > Some epidemiologica...

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FältnamnIndikatorerMetadata
00003054nam a2200301 4500
001oai:DiVA.org:liu-28548
003SwePub
008091009s1993 | |||||||||||000 ||eng|
020 a 9178709318q print
024a urn:nbn:se:liu:diva-285482 urn
040 a (SwePub)liu
041 a engb eng
042 9 SwePub
072 7a vet2 swepub-contenttype
072 7a dok2 swepub-publicationtype
100a Afoke, Anthony Okorou Linköpings universitet,Pediatrik,Hälsouniversitetet4 aut
2451 0a Some epidemiological aspects of insulin-dependent diabetes mellitus in Nigeria and Sweden
264 1a Linköping :b Linköpings universitet,c 1993
300 a 68s.
338 a print2 rdacarrier
490a Linköping University Medical Dissertations,x 0345-0082 ;v 386
500 a Papers, included in the Ph.D. thesis, are not registered and included in the posts from 1999 and backwards.
520 a In the western world diabetes mellitus is one of the most common severe diseases in childhood, but it is rarely seen in black African populations. However, there are very few epidemiological studies of childhood diabetes in Africa and almost nothing is known of the Nigerian population. One aim of this study was therefore to estimate the prevalence of insulin dependent diabetes (IDDM) in children and adolescents and to characterize their type of diabetes.A screening of almost 78,000 school children was performed and beside some already known diabetic patients several new cases were diagnosed. It was found that IDDM is much less common than in Europe but on the other hand more common than in several Asian countries. In addition the prevalence found may be underestimated because of cultural and social factors, health care problems and high mortality in diabetes. Although most patients had a clinical picture of Malnutrition Related Diabetes (MRD) we found in some cases autoantibodies towards islet cells and insulin and furthermore the same HLA-DQ-type-associations as seen to Type 1 diabetes in caucasian diabetics.While we saw no seasonal variation of diagnosis of Nigerian IDDM, there is a pronounced such seasonal variation in Sweden. This study has tried to elucidate whether this seasonal variation is related to any differences in manifestation and clinical course. Patients diagnosed during incidence peaks had more often short duration of symptoms before diagnosis,ketonuria at diagnosis, rapid loss of endogenous insulin secretion but increase of insulin antibodies and of glycosylated haemoglobin. They had also more often infections before diagnosis and high serum immunoglobulins (IgG and IgM) up to 9 months after diagnosis. HLA-DR4 was more common in these patients. The results suggest that IDDM in Swedish children is heterogenous.
653 a MEDICINE
653 a MEDICIN
700a Tuvemo, Torsten,c Docentu Uppsala4 opn
710a Linköpings universitetb Pediatrik4 org
8564 8u http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-28548x lärosäteslänky Till lärosätets (liu) databas

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