Long term follow-up of deep brain stimulation of the caudal zona incerta for essential tremor

Fytagoridis, AndersUmeå universitet,Neurokirurgi,Karolinska University Hospital (författare)

Funding Agencies|Umea University||Foundation for Clinical Neuroscience at the University Hospital of Umea||
Purpose The ventral intermediate nucleus of thalamus is the standard target for deep brain stimulation (DBS) in essential tremor (ET). However, favourable data have recently highlighted the caudal zona incerta (cZi) as an alternative target. Reports concerning the long-term results are however lacking, and we have therefore evaluated the long-term effects in our patients with ET and cZi DBS. less thanbrgreater than less thanbrgreater thanMethods 18 patients were evaluated using the Essential Tremor Rating Scale (ETRS) before and on-/off-stimulation at 1 and 3-5 years after surgery (mean 48.5+/-10.6 months). Two patients were operated on bilaterally but all electrodes were evaluated separately. The stimulation parameters were recorded and the stimulation strength calculated. less thanbrgreater than less thanbrgreater thanResults A baseline total ETRS mean score of 46.0 decreased to 21.9 (52.4%) at the final evaluation. On the treated side, tremor of the upper extremity (item 5 or 6) improved from 6.1 to 0.5 (91.8%) and hand function (items 11-14) improved from 9.3 to 2.0 (78.0%). Activities of daily living improved by 65.8%. There was no increase in stimulation strength over time. less thanbrgreater than less thanbrgreater thanConclusion cZi DBS is a safe and effective treatment for the long term suppression of ET.

Sandvik, UlrikaUmeå universitet,Neurokirurgi,Umeå University(Swepub:umu)ulasak97 (författare)
Åström, MattiasLinköpings universitet,Biomedicinsk instrumentteknik,Tekniska högskolan,MINT(Swepub:liu)matas47 (författare)
Bergenheim, TommyUmeå universitet,Neurokirurgi,Umeå University(Swepub:umu)tobe0004 (författare)
Blomstedt, PatricUmeå universitet,Neurokirurgi,Umeå University(Swepub:umu)pabl0002 (författare)
Umeå universitetNeurokirurgi (creator_code:org_t)

Ingår i:Journal of Neurology, Neurosurgery and Psychiatry: BMJ Publishing Group Ltd83:3, s. 258-2620022-30501468-330X

Av författaren/redakt...: Fytagoridis, And ...; Sandvik, Ulrika; Åström, Mattias; Bergenheim, Tomm ...; Blomstedt, Patri ...

Om ämnet

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Neurologi

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