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- Carlsson, Stina K.,1982-Linnéuniversitetet,Institutionen för naturvetenskap, NV (författare)
Effects of adenosine and acetylcholine on the lacrimal gland
- BokEngelska2011
Förlag, utgivningsår, omfång ...
- Växjö, Kalmar :Linnaeus Univeristy Press,2011
- 76 s.
- printrdacarrier
Nummerbeteckningar
- LIBRIS-ID:oai:DiVA.org:lnu-13636
- ISBN:9789186491970
- https://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-13636URI
Kompletterande språkuppgifter
- Språk:engelska
- Sammanfattning på:engelska
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- SwePubSwePub
Klassifikation
Varianttitlar
- Effekter av adenosin och acetylkolin på tårkörteln
Serie
- Linnaeus University Dissertations ;59
Anmärkningar
- A balanced tear film is essential for a healthy ocular surface. Insufficient tear production may result in dry eye, a common disorder in the elderly population. Dry eye causes significant discomfort in the patients and may lead to visual impairment and ocular infections. The lacrimal gland secretes water, proteins and electrolytes to the aqueous layer of the tear film. Lacrimal gland secretion is tightly regulated by e.g. neuronally released acetylcholine. The effect of acetylcholine on lacrimal gland secretion was recently found to be potentiated by adenosine. Adenosine is an important signaling molecule acting upon the adenosine receptors: A1, A2A, A2B and A3.The aim of this thesis was to study effects of adenosine and acetylcholine on intracellular signaling pathways and lacrimal gland secretion. Cholinergic stimulation of secretion was shown to be regulated by the mitogen activated protein kinase p38, a protein previously not known to be involved in exocrine secretion. p38 was activated in response to cholinergic stimulation and inhibition of p38 significantly diminished cholinergic secretion.When investigating adenosine effects, potentiation of cholinergic secretion was observed by activation of the A2B receptor in addition to the previously studied A1 receptor. An A2 receptor agonist increased cholinergic rabbit lacrimal gland protein secretion at several concentrations. The increase was inhibited by antagonism of the A2B receptor, but not the A2A receptor. When investigating the intracellular signaling pathways following adenosine and acetylcholine receptor activation, adenosine was shown to increase of cAMP levels. An additional increase in cAMP levels was observed after parallel adenosine and cholinergic receptor activation. Inhibition of Ca2+ release from the endoplasmic reticulum had inhibitory effects of cholinergic stimulation of secretion. In addition, the expression of adenosine receptors in a mouse model of autoimmune dry eye was investigated. The results showed a lymphocyte dependent upregulation of A2A receptors in diseased mice compared to controls.In conclusion, the results in this thesis provide significant contributions in the search of dry eye therapeutics through studies of adenosine and acetylcholine receptor activation.
Ämnesord och genrebeteckningar
- MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Cell- och molekylärbiologi hsv//swe
- MEDICAL AND HEALTH SCIENCES Basic Medicine Cell and Molecular Biology hsv//eng
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Oftalmologi hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine Ophthalmology hsv//eng
- NATURVETENSKAP Kemi Biokemi hsv//swe
- NATURAL SCIENCES Chemical Sciences Biochemistry hsv//eng
- NATURVETENSKAP Biologi Molekylärbiologi hsv//swe
- NATURAL SCIENCES Biological Sciences Molecular Biology hsv//eng
- NATURVETENSKAP Biologi Cellbiologi hsv//swe
- NATURAL SCIENCES Biological Sciences Cell Biology hsv//eng
- Lacrimal gland
- adenosine
- adenosine receptors
- signal transduction
- exocrine secretion
- tear film
- dry eye
- Sjögren’s syndrome
- acetylcholine
- mitogen activated protein kinase
- p38
- Cell biology
- Cellbiologi
- Ophtalmology
- Oftalmologi
- Cell and molecular biology
- Cell- och molekylärbiologi
- Cell biology
- Cellbiologi
- Molecular biology
- Molekylärbiologi
- Biomedicinsk vetenskap
- Biomedical Sciences
Biuppslag (personer, institutioner, konferenser, titlar ...)
- Gierow, J. Peter,ProfessorLinnéuniversitetet,Institutionen för naturvetenskap, NV(Swepub:lnu)ngipe (preses)
- Tågerud, Sven,ProfessorLinnéuniversitetet,Institutionen för naturvetenskap, NV(Swepub:lnu)ntasv (preses)
- Dartt, Darlene,Associate professorSchepens Eye Research Institute, Harvard University (opponent)
- LinnéuniversitetetInstitutionen för naturvetenskap, NV (creator_code:org_t)
Internetlänk
- mailto:lnupress@lnu.se?subject=Order: Carlsson Effects of adenosine and acetylcholine on the lacrimal gland&body=Publication: Effects of adenosine and acetylcholine on the lacrimal gland%0D%0AAuthor: Carlsson, Stina K.%0D%0APrice per copy: SEK 400 + VAT and postage%0D%0A%0D%0ANo of Copies: %0D%0ACustomer name: %0D%0ABilling address: %0D%0APostal address:Buy Book (SEK 400 + VAT and postage) lnupress@lnu.se
- https://lnu.diva-portal.org/smash/get/diva2:432893/PREVIEW01.jpgpreview image
- https://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-13636
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