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Sökning: onr:"swepub:oai:DiVA.org:oru-101973" > On the Natural Hist...

  • Mohammad, Moman A.Lund University,Lunds universitet,Molekylär kardiologi,Forskargrupper vid Lunds universitet,Molecular Cardiology,Lund University Research Groups,Skåne University Hospital (författare)

On the Natural History of Coronary Artery Disease : A Longitudinal Nationwide Serial Angiography Study

  • Artikel/kapitelEngelska2022

Förlag, utgivningsår, omfång ...

  • John Wiley & Sons,2022
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:oru-101973
  • https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-101973URI
  • https://doi.org/10.1161/JAHA.122.026396DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-491684URI
  • https://lup.lub.lu.se/record/ba6eb630-85b6-4a6e-b180-1d42e1e75df5URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:151108348URI
  • https://gup.ub.gu.se/publication/319616URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Funding agencies:Bundy Academy Marta Winkler foundation Thorsten Westerströms foundation Anna-Lisa and Sven-Eric Lundgren foundation 
  • Background: The long-term course of coronary atherosclerosis has not been studied in large nationwide cohorts. Understanding the natural history of coronary atherosclerosis could help identify patients at risk for future coronary events.Methods and Results: All coronary artery segments with <50% luminal stenosis in patients with a first-time coronary angiogram between 1989 and 2017 were identified (n=2 661 245 coronary artery segments in 248 736 patients) and followed until a clinically indicated angiography within 15 years was performed or until death or end of follow-up (April 2018) using SCAAR (Swedish Coronary Angiography and Angioplasty Registry). The stenosis progression and incidence rates were 2.6% and 1.45 (95% CI, 1.43-1.46) per 1000 segment-years, respectively. The greatest progression rate occurred in the proximal and middle segments of the left anterior descending artery. Male sex and diabetes were associated with a 2-fold increase in risk, and nearly 70% of new stenoses occurred in patients with baseline single-vessel disease (hazard ratio, 3.86 [95% CI, 3.69-4.04]). Coronary artery segments in patients with no baseline risk factors had a progression rate of 0.6% and incidence rate of 0.36 (95% CI, 0.34-0.39), increasing to 8.1% and 4.01 (95% CI, 3.89-4.14) per 1000 segment-years, respectively, in patients with ≥4 risk factors. The prognostic impact of risk factors on stenosis progression was greatest in younger patients and women.Conclusions: Coronary atherosclerosis progressed slowly but more frequently in the left coronary artery in men and in the presence of traditional risk factors. Coronary artery segments in patients without risk factors had little or no risk of stenosis progression, and the relative impact of risk factors appears to be of greater importance in younger patients and women. These findings help in the understanding the long-term course of coronary atherosclerosis.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Stone, Gregg W.The Zena and Michael A Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai, New York City, NY, USA; Cardiovascular Research Foundation, New York City, NY, USA,Icahn Sch Med Mt Sinai, Zena & Michael Wiener Cardiovasc Inst, New York, NY 10029 USA.;Cardiovasc Res Fdn, New York, NY USA. (författare)
  • Koul, SashaLund University,Lunds universitet,Molekylär kardiologi,Forskargrupper vid Lunds universitet,Molecular Cardiology,Lund University Research Groups,Skåne University Hospital(Swepub:lu)med-sku (författare)
  • Olivecrona, Göran K.Lund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital(Swepub:lu)kard-gol (författare)
  • Bergman, SofiaLund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital(Swepub:lu)so3855ka (författare)
  • Persson, JonasKarolinska Institutet(Swepub:lu)ftf-jpe (författare)
  • Engstrøm, ThomasThe Heart Center, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark,Univ Copenhagen, Rigshosp, Heart Ctr, Copenhagen, Denmark.(Swepub:lu)th4331en (författare)
  • Fröbert, Ole,1964-Örebro University,Örebro universitet,Institutionen för medicinska vetenskaper,Faculty of Health, Department of Cardiology, Örebro University, Örebro, Sweden; Department of Clinical Medicine, Aarhus University Health, Aarhus, Denmark,Örebro Univ, Fac Hlth, Dept Cardiol, Örebro, Sweden.;Aarhus Univ Hlth, Dept Clin Med, Aarhus, Denmark.(Swepub:oru)oft (författare)
  • Jernberg, TomasKarolinska Institutet (författare)
  • Omerovic, Elmir,1968Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine(Swepub:gu)xomeel (författare)
  • James, Stefan,1964-Uppsala University,Uppsala universitet,Kardiologi,Uppsala kliniska forskningscentrum (UCR)(Swepub:uu)stjam367 (författare)
  • Bergström, Göran,1964Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine(Swepub:gu)xbgort (författare)
  • Erlinge, DavidLund University,Lunds universitet,Molekylär kardiologi,Forskargrupper vid Lunds universitet,Molecular Cardiology,Lund University Research Groups,Skåne University Hospital(Swepub:lu)kard-der (författare)
  • Molekylär kardiologiForskargrupper vid Lunds universitet (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Journal of the American Heart Association: John Wiley & Sons11:212047-9980

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