Funding Agencies:Family Planning FoundationFödelsefonden, Uppsala, SwedenRegional Research Foundation, Örebro, SwedenPampers Scholarship, SwedenPraktikertjänst, Stockholm, SwedenMarie Curie postdoctoral fellowship 329812
Folic acid supplements are commonly used by infertile women and lead to a positive folate status. However, the effect of folic acid supplements on pregnancy outcome in women with unexplained infertility has not been well investigated. This study evaluated folic acid supplement use and folate status in women with unexplained infertility in relation to pregnancy outcome. In addition, use of folic acid supplements and folate status were compared between women with unexplained infertility and fertile, nonpregnant control women. Women with unexplained infertility used significantly more folic acid supplements and had higher median total folic acid intake from supplements compared with fertile control women (both P < 0.001). Women with unexplained infertility also had significantly higher median plasma folate and lower median plasma homocysteine concentrations than fertile women (both P < 0.001), but folic acid supplementation or folate status were not related to pregnancy outcome in women with unexplained infertility. In conclusion, folic acid supplementation or good folate status did not have a positive effect on pregnancy outcome following infertility treatment in women with unexplained infertility.
Yngve, Agneta,1953-Örebro universitet,Restaurang- och hotellhögskolan,Department of Biosciences and Nutrition, Karolinska Institutet, Huddinge, Sweden,Örebro University, Karolinska Institutet,Department of Biosciences and Nutrition (BioNut)(Swepub:ki)4ad538a6ae627e6d235f5bdd9440be98
(författare)
Nilsson, Torbjörn K.Umeå universitet,Örebro universitet,Institutionen för hälsovetenskap och medicin,Department of Medical Biosciences, Umeå University, Umeå, Sweden,Klinisk kemi(Swepub:umu)toni0049
(författare)
Altmäe, SigneCompetence Centre on Reproductive Medicine and Biology (CCRMB), Tartu, Estonia; Department of Paediatrics, School of Medicine, University of Granada, Granada, Spain
(författare)
Wånggren, Kjell,1954-Uppsala universitet,Obstetrik & gynekologi,Klinisk och experimentell reproduktionsbiologi/Olovsson(Swepub:uu)kjewa145
(författare)
Salumets, AndreasCompetence Ctr Reprod Med & Biol (CCRMB), Tartu, Estonia; Inst Biomed, Univ Tartu, Tartu, Estonia,University of Tartu, Competence Centre on Reproductive Medicine and Biology, Tartu
(författare)
Stavreus-Evers, AnneliUppsala universitet,Obstetrik & gynekologi,Klinisk och experimentell reproduktionsbiologi/olovsson(Swepub:uu)annst384
(författare)
Uppsala universitetObstetrik & gynekologi
(creator_code:org_t)
Sammanhörande titlar
Ingår i:Reproductive BioMedicine Online: Elsevier28:6, s. 766-7721472-64831472-6491