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Association between baseline serum glucose, triglycerides and total cholesterol, and prostate cancer risk categories

Arthur, Rhonda (författare)
Kings Coll London, Canc Epidemiol Grp, Div Canc Studies, London, England.
Moller, Henrik (författare)
Kings Coll London, Canc Epidemiol Grp, Div Canc Studies, London, England.
Garmo, Hans (författare)
Kings Coll London, Canc Epidemiol Grp, Div Canc Studies, London, England.;Reg Canc Ctr, Uppsala, Sweden.
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Holmberg, Lars (författare)
Uppsala universitet,Institutionen för kirurgiska vetenskaper,Kings Coll London, Canc Epidemiol Grp, Div Canc Studies, London, England.;Reg Canc Ctr, Uppsala, Sweden.
Stattin, Pär (författare)
Uppsala universitet,Umeå universitet,Urologi och andrologi,Faculty of Medicine, Uppsala, Sweden,Urologkirurgi,Departments of Surgical and Perioperative Sciences, Urology and Andrology, Umeå University
Malmstrom, Hakan (författare)
Karolinska Inst, Inst Environm Med, Unit Epidemiol, Stockholm, Sweden.
Lambe, Mats (författare)
Department of Medical Epidemiology and Biostatistics (MEB),Univ Uppsala Hosp, Dept Surg Sci, Uppsala, Sweden.;Karolinska Inst, Dept Med Epidemiol, Stockholm, Sweden.;Karolinska Inst, Dept Biostat, Stockholm, Sweden.
Hammar, Niklas (författare)
Department of Medical Epidemiology and Biostatistics (MEB),Karolinska Inst, Inst Environm Med, Unit Epidemiol, Stockholm, Sweden.;AstraZeneca Sverige, Sodertalje, Sweden.
Walldius, Göran (författare)
Department of Medical Epidemiology and Biostatistics (MEB),Karolinska Inst, Inst Environm Med, Dept Cardiovasc Epidemiol, Stockholm, Sweden.
Robinson, David (författare)
Umeå universitet,Urologi och andrologi,Faculty of Medicine, Uppsala, Sweden,Departments of Surgical and Perioperative Sciences, Urology and Andrology, Umeå University
Arthur, R (författare)
Moller, H (författare)
Garmo, H (författare)
Holmberg, L (författare)
Stattin, P (författare)
Malmstrom, H (författare)
Lambe, M (författare)
Department of Medical Epidemiology and Biostatistics (MEB)
Hammar, N (författare)
Department of Medical Epidemiology and Biostatistics (MEB)
Walldius, G (författare)
Department of Medical Epidemiology and Biostatistics (MEB)
Robinson, D (författare)
Jungner, Ingmar (författare)
Karolinska Inst, Dept Clin Epidemiol Unit, Stockholm, Sweden.;CALAB Res, Stockholm, Sweden.
Van Hemelrijck, Mieke (författare)
Kings Coll London, Canc Epidemiol Grp, Div Canc Studies, London, England.;Karolinska Inst, Inst Environm Med, Unit Epidemiol, Stockholm, Sweden.
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Kings Coll London, Canc Epidemiol Grp, Div Canc Studies, London, England Kings Coll London, Canc Epidemiol Grp, Div Canc Studies, London, England.;Reg Canc Ctr, Uppsala, Sweden. (creator_code:org_t)
2016-02-29
2016
Engelska.
Ingår i: CANCER MEDICINE. - : Wiley. - 2045-7634. ; 5:6, s. 1307-1318
Relaterad länk:
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https://doi.org/10.1...
https://umu.diva-por... (primary) (Raw object)
https://uu.diva-port... (primary) (Raw object)
https://ki.se/en/res...
https://doi.org/10.1...
https://urn.kb.se/re...
https://urn.kb.se/re...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • Lifestyle‐related risk factors such as hyperglycemia and dyslipidemia have been associated with several cancers. However, studies exploring their link with prostate cancer (PCa) clinicopathological characteristics are sparse and inconclusive. Here, we investigated the associations between serum metabolic markers and PCa clinicopathological characteristics. The study comprised 14,294 men from the Swedish Apolipoprotein MOrtality RISk (AMORIS) cohort who were diagnosed with PCa between 1996 and 2011. Univariate and multivariable logistic regression were used to investigate the relation between glucose, triglycerides and total cholesterol and PCa risk categories, PSA, Gleason score, and T‐stage. Mean age at time of PCa diagnosis was 69 years. Men with glucose levels >6.9 mmol/L tend to have PSA<4 μg/L, while those with glucose levels of 5.6–6.9 mmol/L had a greater odds of PSA>20 μg/L compared to PSA 4.0–9.9 μg/L. Hypertriglyceridemia was also positively associated with PSA>20 μg/L. Hyperglycemic men had a greater odds of intermediate‐ and high‐grade PCa and advanced stage or metastatic PCa. Similarly, hypertriglyceridemia was positively associated with high‐grade PCa. There was also a trend toward an increased odds of intermediate risk localized PCa and advanced stage PCa among men with hypertriglyceridemia. Total cholesterol did not have any statistically significant association with any of the outcomes studied. Our findings suggest that high serum levels of glucose and triglycerides may influence PCa aggressiveness and severity. Further investigation on the role of markers of glucose and lipid metabolism in influencing PCa aggressiveness and severity is needed as this may help define important targets for intervention.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Epidemiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Epidemiology (hsv//eng)

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Glucose

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