Inflammatory cytokine of IL-1β is involved in T-2 toxin-triggered chondrocyte injury and metabolism imbalance by the activation of Wnt/β-catenin signaling

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Chang, YanhaiDepartment of Orthopaedics, The Third Affiliated Hospital (Shaanxi Provincial People's Hospital), Health Science Center of Xi’an Jiaotong University, Xi’an, PR China (författare)

Inflammatory cytokine of IL-1β is involved in T-2 toxin-triggered chondrocyte injury and metabolism imbalance by the activation of Wnt/β-catenin signaling

Artikel/kapitelEngelska2017

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Elsevier,2017
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LIBRIS-ID:oai:DiVA.org:umu-140150
https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-140150URI
https://doi.org/10.1016/j.molimm.2017.08.019DOI

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Sammanfattning på:engelska

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Ämneskategori:art swepub-publicationtype

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Mycotoxin T-2 exerts a causative role in Kashin-Beck disease (KBD) suffering chondrocyte apoptosis and cartilage matrix homeostasis disruption. Recent research corroborated the aberrant levels of pro-inflammatory cytokine IL-1ß in KBD patients and mycotoxin environment. In the present study, we investigated the relevance of IL-1ß in T-2 toxin-evoked chondrocyte cytotoxic injury and aberrant catabolism. High levels of IL-1ß were detected in serum and cartilages from KBD patients and in T-2-stimulated chondrocytes. Moreover, knockdown of IL-1ß antagonized the adverse effects of T-2 on cytotoxic injury by enhancing cell viability and inhibiting apoptosis. However, exogenous supplementation of IL-1β further aggravated cell damage in response to T-2. Additionally, cessation of IL-1β rescued T-2-elicited tilt of matrix homeostasis toward catabolism by elevating the transcription of collagen II and aggrecan, promoting release of sulphated glycosaminoglycans (sGAG) and TIMP1, and suppressing matrix metalloproteinases production including MMP-1, MMP-3 and MMP-13. Conversely, IL-1β stimulation deteriorated T-2-induced disruption of matrix metabolism balance toward catabolism. Mechanistic analysis found the high activation of Wnt/β-catenin in KBD patients and chondrocytes upon T-2. Furthermore, this activation was mitigated after IL-1β inhibition, but further enhanced following IL-1β precondition. Importantly, blocking this pathway by transfection with β-catenin alleviated the adverse roles of IL-1β on cytotoxic injury and metabolism disorders under T-2 conditioning. Together, this study elucidates a new insight into how T-2 deteriorates the pathological progression of KBD by regulating inflammation-related pathways, indicating a promising anti-inflammation strategy for KBD therapy.

Ämnesord och genrebeteckningar

MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Cell- och molekylärbiologi hsv//swe
MEDICAL AND HEALTH SCIENCES Basic Medicine Cell and Molecular Biology hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Ortopedi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Orthopaedics hsv//eng
NATURVETENSKAP Kemi Biokemi hsv//swe
NATURAL SCIENCES Chemical Sciences Biochemistry hsv//eng
NATURVETENSKAP Biologi Molekylärbiologi hsv//swe
NATURAL SCIENCES Biological Sciences Molecular Biology hsv//eng
NATURVETENSKAP Biologi Cellbiologi hsv//swe
NATURAL SCIENCES Biological Sciences Cell Biology hsv//eng
Cytotoxic injury
Inflammation
Kashin–Beck disease
Metabolism homeostasis
T-2 toxin
Wnt/β-catenin pathway
biokemi
Biochemistry
cell research
cellforskning
immunologi
Immunology
Medical Cell Biology
medicinsk cellbiologi

Biuppslag (personer, institutioner, konferenser, titlar ...)

Wang, XiaoDepartment of Galactophore, Shaanxi Provincial Cancer Hospital, Xi’an, PR China (författare)
Sun, ZhengmingDepartment of Orthopaedics, The Third Affiliated Hospital (Shaanxi Provincial People's Hospital), Health Science Center of Xi’an Jiaotong University, Xi’an, PR China (författare)
Jin, ZhankuiDepartment of Orthopaedics, The Third Affiliated Hospital (Shaanxi Provincial People's Hospital), Health Science Center of Xi’an Jiaotong University, Xi’an, PR China (författare)
Chen, MingDepartment of Orthopaedics, The Third Affiliated Hospital (Shaanxi Provincial People's Hospital), Health Science Center of Xi’an Jiaotong University, Xi’an, PR China (författare)
Wang, XiaoqingDepartment of Orthopaedics, The Third Affiliated Hospital (Shaanxi Provincial People's Hospital), Health Science Center of Xi’an Jiaotong University, Xi’an, PR China (författare)
Lammi, Mikko,1961-Umeå universitet,Institutionen för integrativ medicinsk biologi (IMB),Chondrogenic and Osteogenic Differentiation Group(Swepub:umu)mila0077 (författare)
Guo, XiongSchool of Public Health, Xi’an Jiaotong University Health Science Center, Key Laboratory of Trace Elements and Endemic Diseases, Ministry of Health, Xi’an, China (författare)
Department of Orthopaedics, The Third Affiliated Hospital (Shaanxi Provincial People's Hospital), Health Science Center of Xi’an Jiaotong University, Xi’an, PR ChinaDepartment of Galactophore, Shaanxi Provincial Cancer Hospital, Xi’an, PR China (creator_code:org_t)

Sammanhörande titlar

Ingår i:Molecular Immunology: Elsevier91, s. 195-2010161-58901872-9142

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Av författaren/redakt...: Chang, Yanhai; Wang, Xiao; Sun, Zhengming; Jin, Zhankui; Chen, Ming; Wang, Xiaoqing; visa fler...; Lammi, Mikko, 19 ...; Guo, Xiong; visa färre...

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Medicinska och f ...; och Cell och molekyl ...

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NATURVETENSKAP: NATURVETENSKAP; och Kemi; och Biokemi

NATURVETENSKAP: NATURVETENSKAP; och Biologi; och Molekylärbiologi

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Av lärosätet: Umeå universitet

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