Prognostic Implications of 2005 Gleason Grade Modification. Population-Based Study of Biochemical Recurrence Following Radical Prostatectomy

Thomsen, Frederik B.Univ Copenhagen, Rigshosp, Copenhagen Prostate Canc Ctr, Copenhagen, Denmark.;Univ Copenhagen, Rigshosp, Dept Urol, Copenhagen, Denmark. (författare)

Objective: To assess the impact of the 2005 modification of the Gleason classification on risk of biochemical recurrence (BCR) after radical prostatectomy (RP). Patients and Methods: In the Prostate Cancer data Base Sweden (PCBaSe), 2,574 men assessed with the original Gleason classification and 1,890 men assessed with the modified Gleason classification, diagnosed between 2003 and 2007, underwent primary RP. Histopathology was reported according to the Gleason Grading Groups (GGG): GGG1 = Gleason score (GS) 6, GGG2 = GS 7(3+4), GGG3 = GS 7(4+3), GGG4 = GS 8 and GGG5 = GS 9-10. Cumulative incidence and multivariable Cox proportional hazards regression models were used to assess difference in BCR. Results: The cumulative incidence of BCR was lower using the modified compared to the original classification: GGG2 (16% vs. 23%), GGG3 (21% vs. 35%) and GGG4 (18% vs. 34%), respectively. Risk of BCR was lower for modified versus original classification, GGG2 Hazard ratio (HR) 0.66, (95% CI 0.49-0.88), GGG3 HR 0.57 (95% CI 0.38-0.88) and GGG4 HR 0.53 (95% CI 0.29-0.94). Conclusion: Due to grade migration following the 2005 Gleason modification, outcome after RP are more favourable. Consequently, outcomes from historical studies cannot directly be applied to a contemporary setting.

Folkvaljon, YasinUniv Uppsala Hosp, Reg Canc Ctr, Uppsala, Sweden. (författare)
Brasso, KlausUniv Copenhagen, Rigshosp, Copenhagen Prostate Canc Ctr, Copenhagen, Denmark.;Univ Copenhagen, Rigshosp, Dept Urol, Copenhagen, Denmark. (författare)
Loeb, StacyNYU, Dept Urol, Populat Hlth, New York, NY USA.;NYU, Laura & Isaac Perlmutter Canc Inst, New York, NY USA.;Manhattan Vet Affairs Med Ctr, New York, NY USA. (författare)
Robinson, DavidUppsala universitet,Institutionen för kirurgiska vetenskaper,Ryhov Hosp, Dept Urol, Jonkoping, Sweden. (författare)
Egevad, LKarolinska Inst, Karolinska Univ Hosp, Dept Oncol Pathol, Stockholm, Sweden.,Department of Oncology-Pathology (OnkPat)(Swepub:ki)5b799ba6bcf709e33f31be84346c3760 (författare)
Stattin, PärUmeå universitet,Uppsala universitet,Urologkirurgi,Umea Univ, Dept Surg & Perioperat Sci, Urol & Androl, Umea, Sweden.,Urologi och andrologi,Department of Surgical Sciences, Uppsala University, Uppsala, Sweden(Swepub:umu)past0003 (författare)
Univ Copenhagen, Rigshosp, Copenhagen Prostate Canc Ctr, Copenhagen, Denmark.;Univ Copenhagen, Rigshosp, Dept Urol, Copenhagen, Denmark.Univ Uppsala Hosp, Reg Canc Ctr, Uppsala, Sweden. (creator_code:org_t)

Av författaren/redakt...: Thomsen, Frederi ...; Folkvaljon, Yasi ...; Brasso, Klaus; Loeb, Stacy; Robinson, David; Egevad, L; visa fler...; Stattin, Pär; visa färre...

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