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Sökning: onr:"swepub:oai:DiVA.org:umu-181555" > Genetic architectur...

Genetic architectures of proximal and distal colorectal cancer are partly distinct

Huyghe, Jeroen R (författare)
Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States
Harrison, Tabitha A (författare)
Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States
Bien, Stephanie A (författare)
Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States
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Hampel, Heather (författare)
Division of Human Genetics, Department of Internal Medicine, The Ohio State University Comprehensive Cancer Center, OH, Columbus, United States
Figueiredo, Jane C (författare)
Department of Preventive Medicine, Keck School of Medicine of the University of Southern California, CA, Los Angeles, United States; Department of Medicine, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, CA, Los Angeles, United States
Schmit, Stephanie L (författare)
Genomic Medicine Institute, Cleveland Clinic, OH, Cleveland, United States
Conti, David V (författare)
Department of Preventive Medicine and Usc Norris Comprehensive Cancer Center, Keck School of Medicine of the University of Southern California, CA, Los Angeles, United States
Chen, Sai (författare)
Department of Biostatistics and Center for Statistical Genetics, University of Michigan, MI, Ann Arbor, United States
Qu, Conghui (författare)
Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States
Lin, Yi (författare)
Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States
Barfield, Richard (författare)
Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States
Baron, John A (författare)
Department of Medicine, University of North Carolina School of Medicine, NC, Chapel Hill, United States
Cross, Amanda J (författare)
Department of Epidemiology and Biostatistics, Imperial College London, London, United Kingdom
Diergaarde, Brenda (författare)
Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, PA, Pittsburgh, United States; Upmc Hillman Cancer Center, PA, Pittsburgh, United States
Duggan, David (författare)
Translational Genomics Research Institute-An Affiliate of City of Hope, AZ, Phoenix, United States
Harlid, Sophia, 1978- (författare)
Umeå universitet,Onkologi
Imaz, Liher (författare)
Public Health Division of Gipuzkoa, Health Department of Basque Country, San Sebastian, Spain
Kang, Hyun Min (författare)
Department of Biostatistics and Center for Statistical Genetics, University of Michigan, MI, Ann Arbor, United States
Levine, David M (författare)
Department of Biostatistics, University of Washington, WA, Seattle, United States
Perduca, Vittorio (författare)
Laboratoire de Mathématiques Appliqueés MAP5 (UMR Cnrs 8145), Université Paris Descartes, Paris, France; Centre for Research in Epidemiology and Population Health (CESP), Institut Pour la Santé et la Recherche Médicale (INSERM) U1018, Université Paris-Saclay, Villejuif, France
Perez-Cornago, Aurora (författare)
Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom
Sakoda, Lori C (författare)
Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States; Division of Research, Kaiser Permanente Northern California, CA, Oakland, United States
Schumacher, Fredrick R (författare)
Department of Population and Quantitative Health Sciences, Case Western Reserve University, OH, Cleveland, United States
Slattery, Martha L (författare)
Department of Internal Medicine, University of Utah Health, UT, Salt Lake City, United States
Toland, Amanda E (författare)
Departments of Cancer Biology and Genetics and Internal Medicine, The Ohio State University, OH, Columbus, United States
Van Duijnhoven, Fränzel J B (författare)
Division of Human Nutrition and Health, Wageningen University and Research, Wageningen, Netherlands
van Guelpen, Bethany (författare)
Umeå universitet,Onkologi
Agudo, Antonio (författare)
Unit of Nutrition and Cancer, Cancer Epidemiology Research Program, Catalan Institute of Oncology-IDIBELL, l'Hospitalet de Llobregat, Barcelona, Spain
Albanes, Demetrius (författare)
Division of Cancer Epidemiology and Genetics, National Cancer Institute, MD, Bethesda, United States
Alonso, M Henar (författare)
Cancer Prevention and Control Program, Catalan Institute of Oncology, IDIBELL, l'Hospitalet de Llobregat, Barcelona, Spain; Ciber Epidemiologiá y Salud Pública (CIBERESP), Madrid, Spain; Department of Clinical Sciences, Faculty of Medicine, University of Barcelona, Barcelona, Spain
Anderson, Kristin (författare)
Division of Epidemiology and Community Health, University of Minnesota, MN, Minneapolis, United States
Arnau-Collell, Coral (författare)
Gastroenterology Department, Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Centro de Investigacion Biomedica en Red de Enfermedades Hepaticas y Digestivas (CIBEREHD), University of Barcelona, Barcelona, Spain
Arndt, Volker (författare)
Division of Clinical Epidemiology and Aging Research, German Cancer Research Centre (DKFZ), Heidelberg, Germany
Banbury, Barbara L (författare)
Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States
Bassik, Michael C (författare)
Department of Genetics, Stanford University, California, Stanford, United States
Berndt, Sonja I (författare)
Division of Cancer Epidemiology and Genetics, National Cancer Institute, MD, Bethesda, United States
Bézieau, Stéphane (författare)
Service de Génétique Médicale, Centre Hospitalier Universitaire (CHU) de Nantes, Nantes, France
Bishop, D Timothy (författare)
Leeds Institute of Medical Research at St James's, University of Leeds, Leeds, United Kingdom
Boehm, Juergen (författare)
Huntsman Cancer Institute and Department of Population Health Sciences, University of Utah Health, Utah, Salt Lake City, United States
Boeing, Heiner (författare)
Department of Epidemiology, German Institute of Human Nutrition (DIfE), Potsdam-Rehbrücke, Germany
Boutron-Ruault, Marie-Christine (författare)
Centre for Research in Epidemiology and Population Health (CESP), Institut Pour la Santé et la Recherche Médicale (INSERM) U1018, Université Paris-Saclay, Villejuif, France; Institut Gustave Roussy, Université Paris-Saclay, Villejuif, France
Brenner, Hermann (författare)
Division of Clinical Epidemiology and Aging Research, German Cancer Research Centre (DKFZ), Heidelberg, Germany; Division of Preventive Oncology, German Cancer Research Centre (DKFZ), National Center for Tumor Diseases (NCT), Heidelberg, Germany; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany
Brezina, Stefanie (författare)
Institute of Cancer Research, Department of Medicine i, Medical University of Vienna, Vienna, Austria
Buch, Stephan (författare)
Department of Medicine i, University Hospital Dresden, Technische Universität Dresden (TU Dresden), Dresden, Germany
Buchanan, Daniel D (författare)
Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, VIC, Melbourne, Australia; Colorectal Oncogenomics Group, Genetic Epidemiology Laboratory, Department of Clinical Pathology, the University of Melbourne, VIC, Melbourne, Australia; Genomic Medicine and Family Cancer Clinic, Royal Melbourne Hospital, VIC, Melbourne, Australia
Burnett-Hartman, Andrea (författare)
Institute for Health Research, Kaiser Permanente Colorado, CO, Denver, United States
Caan, Bette J (författare)
Division of Research, Kaiser Permanente Medical Care Program, CA, Oakland, United States
Campbell, Peter T (författare)
Behavioral and Epidemiology Research Group, American Cancer Society, GA, Atlanta, United States
Carr, Prudence R (författare)
Division of Clinical Epidemiology, German Cancer Research Centre (DKFZ), Heidelberg, Germany
Castells, Antoni (författare)
Gastroenterology Department, Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Centro de Investigacion Biomedica en Red de Enfermedades Hepaticas y Digestivas (CIBEREHD), University of Barcelona, Barcelona, Spain
Castellví-Bel, Sergi (författare)
Gastroenterology Department, Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Centro de Investigacion Biomedica en Red de Enfermedades Hepaticas y Digestivas (CIBEREHD), University of Barcelona, Barcelona, Spain
Chan, Andrew T (författare)
Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, MA, Boston, United States; Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, MA, Boston, United States; Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, MA, Boston, United States; Broad Institute of Harvard and Mit, MA, Cambridge, United States; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Harvard University, MA, Boston, United States; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Harvard University, MA, Boston, United States
Chang-Claude, Jenny (författare)
Division of Cancer Epidemiology, German Cancer Research Centre (DKFZ), Heidelberg, Germany; Cancer Epidemiology Group, University Medical Centre Hamburg-Eppendorf, University Cancer Centre Hamburg (UCCH), Hamburg, Germany
Chanock, Stephen J (författare)
Division of Cancer Epidemiology and Genetics, National Cancer Institute, MD, Bethesda, United States
Curtis, Keith R (författare)
Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States
De La Chapelle, Albert (författare)
Department of Cancer Biology and Genetics and the Comprehensive Cancer Center, The Ohio State University, OH, Columbus, United States
Easton, Douglas F (författare)
Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom
English, Dallas R (författare)
Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, VIC, Melbourne, Australia; Cancer Epidemiology Division, Cancer Council Victoria, VIC, Melbourne, Australia
Feskens, Edith J M (författare)
Division of Human Nutrition and Health, Wageningen University and Research, Wageningen, Netherlands
Gala, Manish (författare)
Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, MA, Boston, United States; Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, MA, Boston, United States
Gallinger, Steven J (författare)
Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, University of Toronto, ON, Toronto, Canada
Gauderman, W James (författare)
Department of Preventive Medicine and Usc Norris Comprehensive Cancer Center, Keck School of Medicine of the University of Southern California, CA, Los Angeles, United States
Giles, Graham G (författare)
Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, VIC, Melbourne, Australia; Cancer Epidemiology Division, Cancer Council Victoria, VIC, Melbourne, Australia
Goodman, Phyllis J (författare)
Swog Statistical Center, Fred Hutchinson Cancer Research Center, WA, Seattle, United States
Grady, William M (författare)
Clinical Research Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States; Department of Medicine, University of Washington School of Medicine, WA, Seattle, United States
Grove, John S (författare)
University of Hawai'i Cancer Center, HI, Honolulu, United States
Gsur, Andrea (författare)
Institute of Cancer Research, Department of Medicine i, Medical University of Vienna, Vienna, Austria
Gunter, Marc J (författare)
Nutrition and Metabolism Section, International Agency for Research on Cancer, World Health Organization, Lyon, France
Haile, Robert W (författare)
Department of Medicine, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, CA, Los Angeles, United States
Hampe, Jochen (författare)
Department of Medicine i, University Hospital Dresden, Technische Universität Dresden (TU Dresden), Dresden, Germany
Hoffmeister, Michael (författare)
Division of Clinical Epidemiology and Aging Research, German Cancer Research Centre (DKFZ), Heidelberg, Germany
Hopper, John L (författare)
Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, VIC, Melbourne, Australia; Department of Epidemiology, School of Public Health and Institute of Health and Environment, Seoul National University, Seoul, South Korea
Hsu, Wan-Ling (författare)
Department of Biostatistics, University of Washington, WA, Seattle, United States
Huang, Wen-Yi (författare)
Division of Cancer Epidemiology and Genetics, National Cancer Institute, MD, Bethesda, United States
Hudson, Thomas J (författare)
Ontario Institute for Cancer Research, ON, Toronto, Canada
Jenab, Mazda (författare)
Nutrition and Metabolism Section, International Agency for Research on Cancer, World Health Organization, Lyon, France
Jenkins, Mark A (författare)
Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, VIC, Melbourne, Australia
Joshi, Amit D (författare)
Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, MA, Boston, United States; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Harvard University, MA, Boston, United States
Keku, Temitope O (författare)
Center for Gastrointestinal Biology and Disease, University of North Carolina, NC, Chapel Hill, United States
Kooperberg, Charles (författare)
Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States
Kühn, Tilman (författare)
Division of Cancer Epidemiology, German Cancer Research Centre (DKFZ), Heidelberg, Germany
Küry, Sébastien (författare)
Service de Génétique Médicale, Centre Hospitalier Universitaire (CHU) de Nantes, Nantes, France
Le Marchand, Loic (författare)
University of Hawai'i Cancer Center, HI, Honolulu, United States
Lejbkowicz, Flavio (författare)
The Clalit Health Services, Personalized Genomic Service, Carmel Medical Center, Haifa, Israel; Department of Community Medicine and Epidemiology, Lady Davis Carmel Medical Center, Haifa, Israel; Clalit National Cancer Control Center, Haifa, Israel
Li, Christopher I (författare)
Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States
Li, Li (författare)
Department of Family Medicine, University of Virginia, VA, Charlottesville, United States
Lieb, Wolfgang (författare)
Institute of Epidemiology, PopGen Biobank, Christian-Albrechts-University Kiel, Kiel, Germany
Lindblom, Annika (författare)
Department of Clinical Genetics, Karolinska University Hospital, Stockholm, Sweden; Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
Lindor, Noralane M (författare)
Department of Health Science Research, Mayo Clinic, AZ, Scottsdale, United States
Männistö, Satu (författare)
Department of Public Health Solutions, National Institute for Health and Welfare, Helsinki, Finland
Markowitz, Sanford D (författare)
Departments of Medicine and Genetics, Case Comprehensive Cancer Center, Case Western Reserve University, University Hospitals of Cleveland, OH, Cleveland, United States
Milne, Roger L (författare)
Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, VIC, Melbourne, Australia; Cancer Epidemiology Division, Cancer Council Victoria, VIC, Melbourne, Australia
Moreno, Lorena (författare)
Gastroenterology Department, Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Centro de Investigacion Biomedica en Red de Enfermedades Hepaticas y Digestivas (CIBEREHD), University of Barcelona, Barcelona, Spain
Murphy, Neil (författare)
Nutrition and Metabolism Section, International Agency for Research on Cancer, World Health Organization, Lyon, France
Nassir, Rami (författare)
Department of Pathology, School of Medicine, Umm Al-Qura'a University, Mecca, Saudi Arabia
Offit, Kenneth (författare)
Clinical Genetics Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, NY, New York, United States; Department of Medicine, Weill Cornell Medical College, NY, New York, United States
Ogino, Shuji (författare)
Broad Institute of Harvard and Mit, MA, Cambridge, United States; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Harvard University, MA, Boston, United States; Department of Oncologic Pathology, Dana-Farber Cancer Institute, MA, Boston, United States; Program in Mpe Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, MA, Boston, United States
Panico, Salvatore (författare)
Dipartimento di Medicina Clinica e Chirurgia, University of Naples Federico II, Naples, Italy
Parfrey, Patrick S (författare)
Clinical Epidemiology Unit, Faculty of Medicine, Memorial University of Newfoundland, Newfoundland, St. John's, Canada
Pearlman, Rachel (författare)
Division of Human Genetics, Department of Internal Medicine, The Ohio State University Comprehensive Cancer Center, OH, Columbus, United States
Pharoah, Paul D P (författare)
Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom
Phipps, Amanda I (författare)
Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States; Department of Epidemiology, University of Washington, WA, Seattle, United States
Platz, Elizabeth A (författare)
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University, MD, Baltimore, United States
Potter, John D (författare)
Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States
Prentice, Ross L (författare)
Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States
Qi, Lihong (författare)
Department of Public Health Sciences, School of Medicine, University of California Davis, CA, Davis, United States
Raskin, Leon (författare)
Division of Epidemiology, Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine, TN, Nashville, United States
Rennert, Gad (författare)
Department of Community Medicine and Epidemiology, Lady Davis Carmel Medical Center, Haifa, Israel; Clalit National Cancer Control Center, Haifa, Israel; Ruth and Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel
Rennert, Hedy S (författare)
Department of Community Medicine and Epidemiology, Lady Davis Carmel Medical Center, Haifa, Israel; Clalit National Cancer Control Center, Haifa, Israel; Ruth and Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel
Riboli, Elio (författare)
School of Public Health, Imperial College London, London, United Kingdom
Schafmayer, Clemens (författare)
Department of General Surgery, University Hospital Rostock, Rostock, Germany
Schoen, Robert E (författare)
Department of Medicine and Epidemiology, University of Pittsburgh Medical Center, PA, Pittsburgh, United States
Seminara, Daniela (författare)
Division of Cancer Control and Population Sciences, National Cancer Institute, MD, Bethesda, United States
Song, Mingyang (författare)
Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, MA, Boston, United States; Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, MA, Boston, United States; Department of Nutrition, Harvard T.H. Chan School of Public Health, Harvard University, MA, Boston, United States
Su, Yu-Ru (författare)
Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States
Tangen, Catherine M (författare)
Swog Statistical Center, Fred Hutchinson Cancer Research Center, WA, Seattle, United States
Thibodeau, Stephen N (författare)
Division of Laboratory Genetics, Department of Laboratory Medicine and Pathology, MayoClinic, MN, Rochester, United States
Thomas, Duncan C (författare)
Department of Preventive Medicine and Usc Norris Comprehensive Cancer Center, Keck School of Medicine of the University of Southern California, CA, Los Angeles, United States
Trichopoulou, Antonia (författare)
Hellenic Health Foundation, Athens, Greece; Who Collaborating Center for Nutrition and Health, Unit of Nutritional Epidemiology and Nutrition in Public Health, Department of Hygiene, Epidemiology and Medical Statistics, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece
Ulrich, Cornelia M (författare)
Huntsman Cancer Institute and Department of Population Health Sciences, University of Utah Health, Utah, Salt Lake City, United States
Visvanathan, Kala (författare)
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University, MD, Baltimore, United States
Vodicka, Pavel (författare)
Department of Molecular Biology of Cancer, Institute of Experimental Medicine of the Czech Academy of Sciences, Prague, Czech Republic; Institute of Biology and Medical Genetics, First Faculty of Medicine, Charles University, Prague, Czech Republic; Faculty of Medicine and Biomedical Center in Pilsen, Charles University, Pilsen, Czech Republic
Vodickova, Ludmila (författare)
Department of Molecular Biology of Cancer, Institute of Experimental Medicine of the Czech Academy of Sciences, Prague, Czech Republic; Institute of Biology and Medical Genetics, First Faculty of Medicine, Charles University, Prague, Czech Republic; Faculty of Medicine and Biomedical Center in Pilsen, Charles University, Pilsen, Czech Republic
Vymetalkova, Veronika (författare)
Department of Molecular Biology of Cancer, Institute of Experimental Medicine of the Czech Academy of Sciences, Prague, Czech Republic; Institute of Biology and Medical Genetics, First Faculty of Medicine, Charles University, Prague, Czech Republic; Faculty of Medicine and Biomedical Center in Pilsen, Charles University, Pilsen, Czech Republic
Weigl, Korbinian (författare)
Division of Clinical Epidemiology and Aging Research, German Cancer Research Centre (DKFZ), Heidelberg, Germany; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany; Medical Faculty, University of Heidelberg, Heidelberg, Germany
Weinstein, Stephanie J (författare)
Division of Cancer Epidemiology and Genetics, National Cancer Institute, MD, Bethesda, United States
White, Emily (författare)
Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States
Wolk, Alicja (författare)
Uppsala universitet,Institutionen för kirurgiska vetenskaper
Woods, Michael O (författare)
Discipline of Genetics, Memorial University of Newfoundland, Newfoundland, St. John's, Canada
Wu, Anna H (författare)
Department of Preventive Medicine and Usc Norris Comprehensive Cancer Center, Keck School of Medicine of the University of Southern California, CA, Los Angeles, United States
Abecasis, Goncalo R (författare)
Department of Biostatistics and Center for Statistical Genetics, University of Michigan, MI, Ann Arbor, United States
Nickerson, Deborah A (författare)
Department of Genome Sciences, University of Washington, WA, Seattle, United States
Scacheri, Peter C (författare)
Department of Genetics and Genome Sciences, Case Western Reserve University School of Medicine, Case Comprehensive Cancer Center, OH, Cleveland, United States
Kundaje, Anshul (författare)
Department of Genetics, Stanford University, California, Stanford, United States; Department of Computer Science, Stanford University, CA, Stanford, United States
Casey, Graham (författare)
Center for Public Health Genomics, University of Virginia, VA, Charlottesville, United States
Gruber, Stephen B (författare)
Department of Preventive Medicine, Usc Norris Comprehensive Cancer Center, University of Southern California Keck School of Medicine, CA, Los Angeles, United States; City of Hope National Medical Center, CA, Duarte, United States
Hsu, Li (författare)
Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States; Department of Biostatistics, University of Washington, WA, Seattle, United States
Moreno, Victor (författare)
Cancer Prevention and Control Program, Catalan Institute of Oncology, IDIBELL, l'Hospitalet de Llobregat, Barcelona, Spain; Ciber Epidemiologiá y Salud Pública (CIBERESP), Madrid, Spain; Department of Clinical Sciences, Faculty of Medicine, University of Barcelona, Barcelona, Spain
Hayes, Richard B (författare)
Division of Epidemiology, Department of Population Health, New York University School of Medicine, NY, New York, United States
Newcomb, Polly A (författare)
Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States; Department of Epidemiology, University of Washington, WA, Seattle, United States
Peters, Ulrike (författare)
Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States; Department of Epidemiology, University of Washington, WA, Seattle, United States
Levine, DM (författare)
Lejbkowicz, F (författare)
Vodicka, P (författare)
Brenner, H (författare)
Goodman, PJ (författare)
Haile, RW (författare)
Bishop, DT (författare)
Chan, AT (författare)
Moreno, L (författare)
Slattery, ML (författare)
Harrison, TA (författare)
Gunter, MJ (författare)
Gala, M (författare)
Potter, JD (författare)
Castellví-Bel, S (författare)
Schumacher, FR (författare)
Cross, AJ (författare)
Grove, JS (författare)
Weigl, K (författare)
Scacheri, PC (författare)
Huyghe, JR (författare)
Imaz, L (författare)
Platz, EA (författare)
Lindblom, A (författare)
Karolinska Institutet
Casey, G (författare)
Chen, S (författare)
Hoffmeister, M (författare)
Schafmayer, C (författare)
Duggan, D (författare)
Gauderman, WJ (författare)
Nickerson, DA (författare)
Gruber, SB (författare)
Thibodeau, SN (författare)
Pharoah, PDP (författare)
Song, M (författare)
Rennert, HS (författare)
Arndt, V (författare)
Lieb, W (författare)
Markowitz, SD (författare)
Vymetalkova, V (författare)
Bézieau, S (författare)
Boutron-Ruault, MC (författare)
Parfrey, PS (författare)
Li, CI (författare)
Li, L (författare)
de la Chapelle, A (författare)
Le Marchand, L (författare)
Vodickova, L (författare)
Curtis, KR (författare)
Hsu, L (författare)
Berndt, SI (författare)
Lin, Y (författare)
Banbury, BL (författare)
Keku, TO (författare)
Castells, A (författare)
Hampel, H (författare)
Arnau-Collell, C (författare)
Qu, C (författare)
Baron, JA (författare)
Perduca, V (författare)
Hudson, TJ (författare)
Panico, S (författare)
White, E (författare)
Hopper, JL (författare)
English, DR (författare)
Alonso, MH (författare)
Ogino, S (författare)
Easton, DF (författare)
van Duijnhoven, FJB (författare)
Burnett-Hartman, A (författare)
Moreno, V (författare)
Ulrich, CM (författare)
Giles, GG (författare)
Gallinger, SJ (författare)
Caan, BJ (författare)
Huang, WY (författare)
Brezina, S (författare)
Schoen, RE (författare)
Gsur, A (författare)
Milne, RL (författare)
Prentice, RL (författare)
Nassir, R (författare)
Wu, AH (författare)
Figueiredo, JC (författare)
Anderson, K (författare)
Küry, S (författare)
Riboli, E (författare)
Boehm, J (författare)
Pearlman, R (författare)
Buch, S (författare)
Van Guelpen, B (författare)
Kang, HM (författare)
Boeing, H (författare)
Lindor, NM (författare)
Qi, L (författare)
Kundaje, A (författare)
Su, YR (författare)
Bassik, MC (författare)
Albanes, D (författare)
Peters, U (författare)
Tangen, CM (författare)
Männistö, S (författare)
Kühn, T (författare)
Seminara, D (författare)
Buchanan, DD (författare)
Schmit, SL (författare)
Perez-Cornago, A (författare)
Woods, MO (författare)
Chang-Claude, J (författare)
Thomas, DC (författare)
Offit, K (författare)
Visvanathan, K (författare)
Rennert, G (författare)
Carr, PR (författare)
Jenab, M (författare)
Sakoda, LC (författare)
Weinstein, SJ (författare)
Chanock, SJ (författare)
Joshi, AD (författare)
Conti, DV (författare)
Trichopoulou, A (författare)
Campbell, PT (författare)
Hayes, RB (författare)
Grady, WM (författare)
Kooperberg, C (författare)
Diergaarde, B (författare)
Wolk, A (författare)
Karolinska Institutet
Newcomb, PA (författare)
Raskin, L (författare)
Murphy, N (författare)
Toland, AE (författare)
Agudo, A (författare)
Phipps, AI (författare)
Hsu, WL (författare)
Feskens, EJM (författare)
Abecasis, GR (författare)
Jenkins, MA (författare)
Bien, SA (författare)
Harlid, S (författare)
Barfield, R (författare)
Hampe, J (författare)
Kuhn, T (författare)
Qu, CH (författare)
Kury, S (författare)
Qi, LH (författare)
Mannisto, S (författare)
Bezieau, S (författare)
Castellvi-Bel, S (författare)
van Duijnhoven, Fränzel J B (författare)
Van Guelpen, Bethany (författare)
de la Chapelle, Albert (författare)
visa färre...
 (creator_code:org_t)
BMJ Publishing Group Ltd, 2021
2021
Engelska.
Ingår i: Gut. - : BMJ Publishing Group Ltd. - 0017-5749 .- 1468-3288.
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • Objective: An understanding of the etiologic heterogeneity of colorectal cancer (CRC) is critical for improving precision prevention, including individualized screening recommendations and the discovery of novel drug targets and repurposable drug candidates for chemoprevention. Known differences in molecular characteristics and environmental risk factors among tumors arising in different locations of the colorectum suggest partly distinct mechanisms of carcinogenesis. The extent to which the contribution of inherited genetic risk factors for CRC differs by anatomical subsite of the primary tumor has not been examined.Design: To identify new anatomical subsite-specific risk loci, we performed genome-wide association study (GWAS) meta-analyses including data of 48 214 CRC cases and 64 159 controls of European ancestry. We characterised effect heterogeneity at CRC risk loci using multinomial modelling.Results: We identified 13 loci that reached genome-wide significance (p<5×10-8) and that were not reported by previous GWASs for overall CRC risk. Multiple lines of evidence support candidate genes at several of these loci. We detected substantial heterogeneity between anatomical subsites. Just over half (61) of 109 known and new risk variants showed no evidence for heterogeneity. In contrast, 22 variants showed association with distal CRC (including rectal cancer), but no evidence for association or an attenuated association with proximal CRC. For two loci, there was strong evidence for effects confined to proximal colon cancer.Conclusion: Genetic architectures of proximal and distal CRC are partly distinct. Studies of risk factors and mechanisms of carcinogenesis, and precision prevention strategies should take into consideration the anatomical subsite of the tumour.

Ämnesord

MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Medical Genetics (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper (hsv//swe)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine (hsv//eng)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine (hsv//eng)

Nyckelord

cancer genetics
cancer susceptibility
colon carcinogenesis
colorectal cancer
genetic polymorphisms

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Wolk, Alicja
Woods, Michael O
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Abecasis, Goncal ...
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Kundaje, Anshul
Casey, Graham
Gruber, Stephen ...
Hsu, Li
Moreno, Victor
Hayes, Richard B
Newcomb, Polly A
Peters, Ulrike
Levine, DM
Lejbkowicz, F
Vodicka, P
Brenner, H
Goodman, PJ
Haile, RW
Bishop, DT
Chan, AT
Moreno, L
Slattery, ML
Harrison, TA
Gunter, MJ
Gala, M
Potter, JD
Castellví-Bel, S
Schumacher, FR
Cross, AJ
Grove, JS
Weigl, K
Scacheri, PC
Huyghe, JR
Imaz, L
Platz, EA
Lindblom, A
Casey, G
Chen, S
Hoffmeister, M
Schafmayer, C
Duggan, D
Gauderman, WJ
Nickerson, DA
Gruber, SB
Thibodeau, SN
Pharoah, PDP
Song, M
Rennert, HS
Arndt, V
Lieb, W
Markowitz, SD
Vymetalkova, V
Bézieau, S
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Parfrey, PS
Li, CI
Li, L
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Le Marchand, L
Vodickova, L
Curtis, KR
Hsu, L
Berndt, SI
Lin, Y
Banbury, BL
Keku, TO
Castells, A
Hampel, H
Arnau-Collell, C
Qu, C
Baron, JA
Perduca, V
Hudson, TJ
Panico, S
White, E
Hopper, JL
English, DR
Alonso, MH
Ogino, S
Easton, DF
van Duijnhoven, ...
Burnett-Hartman, ...
Moreno, V
Ulrich, CM
Giles, GG
Gallinger, SJ
Caan, BJ
Huang, WY
Brezina, S
Schoen, RE
Gsur, A
Milne, RL
Prentice, RL
Nassir, R
Wu, AH
Figueiredo, JC
Anderson, K
Küry, S
Riboli, E
Boehm, J
Pearlman, R
Buch, S
Van Guelpen, B
Kang, HM
Boeing, H
Lindor, NM
Qi, L
Kundaje, A
Su, YR
Bassik, MC
Albanes, D
Peters, U
Tangen, CM
Männistö, S
Kühn, T
Seminara, D
Buchanan, DD
Schmit, SL
Perez-Cornago, A
Woods, MO
Chang-Claude, J
Thomas, DC
Offit, K
Visvanathan, K
Rennert, G
Carr, PR
Jenab, M
Sakoda, LC
Weinstein, SJ
Chanock, SJ
Joshi, AD
Conti, DV
Trichopoulou, A
Campbell, PT
Hayes, RB
Grady, WM
Kooperberg, C
Diergaarde, B
Wolk, A
Newcomb, PA
Raskin, L
Murphy, N
Toland, AE
Agudo, A
Phipps, AI
Hsu, WL
Feskens, EJM
Abecasis, GR
Jenkins, MA
Bien, SA
Harlid, S
Barfield, R
Hampe, J
Kuhn, T
Qu, CH
Kury, S
Qi, LH
Mannisto, S
Bezieau, S
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