SwePub
Sök i LIBRIS databas

  Utökad sökning

onr:"swepub:oai:DiVA.org:umu-184500"
 

Sökning: onr:"swepub:oai:DiVA.org:umu-184500" > Genetically predict...

Genetically predicted circulating concentrations of micronutrients and risk of colorectal cancer among individuals of European descent : a Mendelian randomization study

Tsilidis, Konstantinos K. (författare)
Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom
Papadimitriou, Nikos (författare)
Section of Nutrition and Metabolism, International Agency for Research on Cancer, Lyon, France
Dimou, Niki (författare)
Section of Nutrition and Metabolism, International Agency for Research on Cancer, Lyon, France
visa fler...
Gill, Dipender (författare)
Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom
Lewis, Sarah J. (författare)
Department of Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom; Medical Research Council Integrative Epidemiology Unit, Department of Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom
Martin, Richard M. (författare)
Department of Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom; Medical Research Council Integrative Epidemiology Unit, Department of Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom; University Hospitals Bristol National Health Service Foundation Trust National Institute for Health Research Bristol Biomedical Research Centre, University of Bristol, Bristol, United Kingdom
Murphy, Neil (författare)
Section of Nutrition and Metabolism, International Agency for Research on Cancer, Lyon, France
Markozannes, Georgios (författare)
Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece
Zuber, Verena (författare)
Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom; Medical Research Council Biostatistics Unit, School of Clinical Medicine, University of Cambridge, Cambridge, United Kingdom
Cross, Amanda J. (författare)
Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom
Burrows, Kimberley (författare)
Department of Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom; Medical Research Council Integrative Epidemiology Unit, Department of Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom
Lopez, David S. (författare)
Department of Preventive Medicine and Community Health, University of Texas Medical Branch, TX, Galveston, United States
Key, Timothy J. (författare)
Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom
Travis, Ruth C. (författare)
Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom
Perez-Cornago, Aurora (författare)
Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom
Hunter, David J. (författare)
Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom
van Duijnhoven, Fränzel J B (författare)
Division of Human Nutrition and Health, Wageningen University & Research, Wageningen, Netherlands
Albanes, Demetrius (författare)
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, MD, Bethesda, United States
Arndt, Volker (författare)
Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany
Berndt, Sonja I. (författare)
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, MD, Bethesda, United States
Bézieau, Stéphane (författare)
Medical Genetics Service, University Hospital Center (CHU) Nantes, Nantes, France
Bishop, D Timothy (författare)
Leeds Institute of Cancer and Pathology, University of Leeds, Leeds, United Kingdom
Boehm, Juergen (författare)
Huntsman Cancer Institute, University of Utah, UT, Salt Lake City, United States; Department of Population Health Sciences, University of Utah, UT, Salt Lake City, United States
Brenner, Hermann (författare)
Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany; Division of Preventive Oncology, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), Heidelberg, Germany; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany
Burnett-Hartman, Andrea (författare)
Institute for Health Research, Kaiser Permanente Colorado, CO, Denver, United States
Campbell, Peter T. (författare)
Behavioral and Epidemiology Research Group, American Cancer Society, Atlanta, United States
Casey, Graham (författare)
Center for Public Health Genomics, University of Virginia, VA, Charlottesville, United States
Castellví-Bel, Sergi (författare)
Gastroenterology Department, Hospital Clinic, August Pi i Sunyer Biomedical Research Institute (IDIBAPS), Biomedical Research Network Center for Liver and Digestive Diseases (CIBEREHD), University of Barcelona, Barcelona, Spain
Chan, Andrew T. (författare)
Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, MA, Boston, United States; Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, MA, Boston, United States; Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, MA, Boston, United States; Broad Institute of Harvard and MIT, MA, Cambridge, United States; Department of Epidemiology, Harvard TH Chan School of Public Health, Harvard University, MA, Boston, United States; Department of Immunology and Infectious Diseases, Harvard TH Chan School of Public Health, Harvard University, MA, Boston, United States
Chang-Claude, Jenny (författare)
Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany; University Medical Centre Hamburg-Eppendorf, University Cancer Centre Hamburg, Hamburg, Germany
de la Chapelle, Albert (författare)
Department of Cancer Biology and Genetics, The Ohio State University, Columbus, OH, USA; Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA
Figueiredo, Jane C. (författare)
Department of Medicine, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA; Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
Gallinger, Steven J. (författare)
Lunenfeld Tanenbaum Research Institute, University of Toronto, Mount Sinai Hospital, ON, Toronto, Canada
Giles, Graham G. (författare)
Cancer Epidemiology Division, Cancer Council Victoria, VIC, Melbourne, Australia; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, VIC, Melbourne, Australia; Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, VIC, Clayton, Australia
Goodman, Phyllis J. (författare)
SWOG Statistical Center, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
Gsur, Andrea (författare)
Institute of Cancer Research, Department of Medicine I, Medical University Vienna, Vienna, Austria
Hampe, Jochen (författare)
Department of Medicine I, University Hospital Dresden, Dresden University of Technology (TU Dresden), Dresden, Germany
Hampel, Heather (författare)
Division of Human Genetics, Department of Internal Medicine, The Ohio State University, Columbus, OH, USA
Hoffmeister, Michael (författare)
Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany
Jenkins, Mark A. (författare)
Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, VIC, Melbourne, Australia
Keku, Temitope O. (författare)
Center for Gastrointestinal Biology and Disease, University of North Carolina, Chapel Hill, United States
Kweon, Sun-Seog (författare)
Department of Preventive Medicine, Chonnam National University Medical School, Gwangju, South Korea; Jeonnam Regional Cancer Center, Chonnam National University Hwasun Hospital, Hwasun, South Korea
Larsson, Susanna C. (författare)
Karolinska Institutet
Le Marchand, Loic (författare)
University of Hawaii Cancer Center, HI, Honolulu, United States
Li, Christopher I. (författare)
Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
Li, Li (författare)
Department of Family Medicine, University of Virginia, VA, Charlottesville, United States
Lindblom, Annika (författare)
Karolinska Institutet
Martín, Vicente (författare)
CIBER of Epidemiology and Public Health (CIBERESP), Madrid, Spain; Biomedicine Institute (IBIOMED), University of León, León, Spain
Milne, Roger L. (författare)
Cancer Epidemiology Division, Cancer Council Victoria, VIC, Melbourne, Australia; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, VIC, Melbourne, Australia; Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, VIC, Clayton, Australia
Moreno, Victor (författare)
CIBER of Epidemiology and Public Health (CIBERESP), Madrid, Spain; Oncology Data Analytics Program, Catalan Institute of Oncology-Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain; Department of Clinical Sciences, Faculty of Medicine, University of Barcelona, Barcelona, Spain; ONCOBEL Program, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain
Nan, Hongmei (författare)
Department of Epidemiology, Richard M Fairbanks School of Public Health, Indiana University, IN, Indianapolis, United States; IU Melvin and Bren Simon Cancer Center, Indiana University, IN, Indianapolis, United States
Nassir, Rami (författare)
Department of Pathology, School of Medicine, Umm Al-Qura'a University, Mecca, Saudi Arabia
Newcomb, Polly A. (författare)
Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA; School of Public Health, University of Washington, Seattle, WA, USA
Offit, Kenneth (författare)
Clinical Genetics Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, NY, NY, United States; Department of Medicine, Weill Cornell Medical College, NY, NY, United States
Pharoah, Paul D P (författare)
Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom
Platz, Elizabeth A. (författare)
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, MD, Baltimore, United States
Potter, John D. (författare)
Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA; Centre for Public Health Research, Massey University, Wellington, New Zealand
Qi, Lihong (författare)
Department of Public Health Sciences, School of Medicine, University of California Davis, Davis, CA, USA
Rennert, Gad (författare)
Department of Community Medicine and Epidemiology, Lady Davis Carmel Medical Center, Haifa, Israel; Ruth and Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel; Clalit National Cancer Control Center, Haifa, Israel
Sakoda, Lori C. (författare)
Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA; Division of Research, Kaiser Permanente Northern California, Oakland, CA, USA
Schafmayer, Clemens (författare)
Department of General Surgery, University Hospital Rostock, Rostock, Germany
Slattery, Martha L. (författare)
Department of Internal Medicine, University of Utah, UT, Salt Lake City, United States
Snetselaar, Linda (författare)
Department of Epidemiology, University of Iowa College of Public Health, IA, Iowa City, United States
Schenk, Jeanette (författare)
SWOG Statistical Center, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
Thibodeau, Stephen N. (författare)
Division of Laboratory Genetics, Department of Laboratory Medicine and Pathology, Mayo Clinic, MN, Rochester, United States
Ulrich, Cornelia M. (författare)
Huntsman Cancer Institute, University of Utah, UT, Salt Lake City, United States; Department of Population Health Sciences, University of Utah, UT, Salt Lake City, United States
van Guelpen, Bethany (författare)
Umeå universitet,Onkologi
Harlid, Sophia, 1978- (författare)
Umeå universitet,Onkologi
Visvanathan, Kala (författare)
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, MD, Baltimore, United States
Vodickova, Ludmila (författare)
Department of Molecular Biology of Cancer, Institute of Experimental Medicine of the Czech Academy of Sciences, Prague, Czech Republic; Institute of Biology and Medical Genetics, First Faculty of Medicine, Charles University, Prague, Czech Republic; Faculty of Medicine and Biomedical Center in Pilsen, Charles University, Pilsen, Czech Republic
Wang, Hansong (författare)
University of Hawaii Cancer Center, HI, Honolulu, United States
White, Emily (författare)
Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA; Department of Epidemiology, University of Washington, Seattle, WA, USA
Wolk, Alicja (författare)
Karolinska Institutet
Woods, Michael O. (författare)
Discipline of Genetics, Memorial University of Newfoundland, St. John's ,Newfoundland, Canada
Wu, Anna H. (författare)
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
Zheng, Wei (författare)
Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine, TN, Nashville, United States
Bueno-de-Mesquita, Bas (författare)
Formerly, Department for Determinants of Chronic Diseases (DCD), National Institute for Public Health and the Environment (RIVM), Bilthoven, Netherlands
Boutron-Ruault, Marie-Christine (författare)
Faculty of Medicine, CESP, University of Paris-Sud, Faculty of Medicine UVSQ, INSERM, University of Paris-Saclay, Villejuif, France; Centre for Research in Epidemiology and Population Health (CESP), Gustave Roussy, Villejuif, France
Hughes, David J. (författare)
Cancer Biology and Therapeutics Group, UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin, Ireland
Jakszyn, Paula (författare)
Unit of Nutrition and Cancer, Cancer Epidemiology Research Program, Catalan Institute of Oncology- Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain; Blanquerna Faculty of Health Sciences, Ramon Llull University, Barcelona, Spain
Kühn, Tilman (författare)
Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany
Palli, Domenico (författare)
Cancer Risk Factors and Life-Style Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network-ISPRO, Florence, Italy
Riboli, Elio (författare)
Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom
Giovannucci, Edward L. (författare)
Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, MA, Boston, United States; Department of Epidemiology, Harvard TH Chan School of Public Health, Harvard University, MA, Boston, United States; Department of Nutrition, Harvard TH Chan School of Public Health, Harvard University, MA, Boston, United States
Banbury, Barbara L. (författare)
Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
Gruber, Stephen B. (författare)
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA; USC Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, USA
Peters, Ulrike (författare)
Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA; Department of Epidemiology, University of Washington, Seattle, WA, USA
Gunter, Marc J. (författare)
Section of Nutrition and Metabolism, International Agency for Research on Cancer, Lyon, France
visa färre...
 (creator_code:org_t)
Oxford University Press, 2021
2021
Engelska.
Ingår i: American Journal of Clinical Nutrition. - : Oxford University Press. - 0002-9165 .- 1938-3207. ; 113:6, s. 1490-1502
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • BACKGROUND: The literature on associations of circulating concentrations of minerals and vitamins with risk of colorectal cancer is limited and inconsistent. Evidence from randomized controlled trials (RCTs) to support the efficacy of dietary modification or nutrient supplementation for colorectal cancer prevention is also limited.OBJECTIVES: To complement observational and RCT findings, we investigated associations of genetically predicted concentrations of 11 micronutrients (β-carotene, calcium, copper, folate, iron, magnesium, phosphorus, selenium, vitamin B-6, vitamin B-12, and zinc) with colorectal cancer risk using Mendelian randomization (MR). METHODS: Two-sample MR was conducted using 58,221 individuals with colorectal cancer and 67,694 controls from the Genetics and Epidemiology of Colorectal Cancer Consortium, Colorectal Cancer Transdisciplinary Study, and Colon Cancer Family Registry. Inverse variance-weighted MR analyses were performed with sensitivity analyses to assess the impact of potential violations of MR assumptions.RESULTS: Nominally significant associations were noted for genetically predicted iron concentration and higher risk of colon cancer [ORs per SD (ORSD): 1.08; 95% CI: 1.00, 1.17; P value = 0.05] and similarly for proximal colon cancer, and for vitamin B-12 concentration and higher risk of colorectal cancer (ORSD: 1.12; 95% CI: 1.03, 1.21; P value = 0.01) and similarly for colon cancer. A nominally significant association was also noted for genetically predicted selenium concentration and lower risk of colon cancer (ORSD: 0.98; 95% CI: 0.96, 1.00; P value = 0.05) and similarly for distal colon cancer. These associations were robust to sensitivity analyses. Nominally significant inverse associations were observed for zinc and risk of colorectal and distal colon cancers, but sensitivity analyses could not be performed. None of these findings survived correction for multiple testing. Genetically predicted concentrations of β-carotene, calcium, copper, folate, magnesium, phosphorus, and vitamin B-6 were not associated with disease risk.CONCLUSIONS: These results suggest possible causal associations of circulating iron and vitamin B-12 (positively) and selenium (inversely) with risk of colon cancer.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Hälsovetenskap -- Näringslära (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Medical Genetics (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)

Nyckelord

colorectal cancer
genes
Mendelian randomization
nutrition
supplements

Publikations- och innehållstyp

ref (ämneskategori)
art (ämneskategori)

Hitta via bibliotek

Till lärosätets databas

Hitta mer i SwePub

Av författaren/redakt...
Tsilidis, Konsta ...
Papadimitriou, N ...
Dimou, Niki
Gill, Dipender
Lewis, Sarah J.
Martin, Richard ...
visa fler...
Murphy, Neil
Markozannes, Geo ...
Zuber, Verena
Cross, Amanda J.
Burrows, Kimberl ...
Lopez, David S.
Key, Timothy J.
Travis, Ruth C.
Perez-Cornago, A ...
Hunter, David J.
van Duijnhoven, ...
Albanes, Demetri ...
Arndt, Volker
Berndt, Sonja I.
Bézieau, Stéphan ...
Bishop, D Timoth ...
Boehm, Juergen
Brenner, Hermann
Burnett-Hartman, ...
Campbell, Peter ...
Casey, Graham
Castellví-Bel, S ...
Chan, Andrew T.
Chang-Claude, Je ...
de la Chapelle, ...
Figueiredo, Jane ...
Gallinger, Steve ...
Giles, Graham G.
Goodman, Phyllis ...
Gsur, Andrea
Hampe, Jochen
Hampel, Heather
Hoffmeister, Mic ...
Jenkins, Mark A.
Keku, Temitope O ...
Kweon, Sun-Seog
Larsson, Susanna ...
Le Marchand, Loi ...
Li, Christopher ...
Li, Li
Lindblom, Annika
Martín, Vicente
Milne, Roger L.
Moreno, Victor
Nan, Hongmei
Nassir, Rami
Newcomb, Polly A ...
Offit, Kenneth
Pharoah, Paul D ...
Platz, Elizabeth ...
Potter, John D.
Qi, Lihong
Rennert, Gad
Sakoda, Lori C.
Schafmayer, Clem ...
Slattery, Martha ...
Snetselaar, Lind ...
Schenk, Jeanette
Thibodeau, Steph ...
Ulrich, Cornelia ...
van Guelpen, Bet ...
Harlid, Sophia, ...
Visvanathan, Kal ...
Vodickova, Ludmi ...
Wang, Hansong
White, Emily
Wolk, Alicja
Woods, Michael O ...
Wu, Anna H.
Zheng, Wei
Bueno-de-Mesquit ...
Boutron-Ruault, ...
Hughes, David J.
Jakszyn, Paula
Kühn, Tilman
Palli, Domenico
Riboli, Elio
Giovannucci, Edw ...
Banbury, Barbara ...
Gruber, Stephen ...
Peters, Ulrike
Gunter, Marc J.
visa färre...
Om ämnet
MEDICIN OCH HÄLSOVETENSKAP
MEDICIN OCH HÄLS ...
och Hälsovetenskap
och Näringslära
MEDICIN OCH HÄLSOVETENSKAP
MEDICIN OCH HÄLS ...
och Medicinska och f ...
och Medicinsk geneti ...
MEDICIN OCH HÄLSOVETENSKAP
MEDICIN OCH HÄLS ...
och Klinisk medicin
och Cancer och onkol ...
Artiklar i publikationen
American Journal ...
Av lärosätet
Umeå universitet
Uppsala universitet
Karolinska Institutet

Sök utanför SwePub

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy