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Sökning: onr:"swepub:oai:DiVA.org:umu-185763" > The genetic organiz...

The genetic organization of longitudinal subcortical volumetric change is stable throughout the lifespan running title: Genetics of subcortical lifespan change

Fjell, Anders M. (författare)
Research Group for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Norway; Department of Radiology and Nuclear Medicine, Oslo University Hospital, Oslo, Norway
Grydeland, Håkon (författare)
Research Group for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Norway
Wang, Yunpeng (författare)
Research Group for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Norway
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Amlien, Inge (författare)
Research Group for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Norway
Bartrés-Faz, David (författare)
Departament de Medicina, Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona, and Institut de Neurociències, Universitat de Barcelona, Spain
Brandmaier, Andreas M. (författare)
Center for Lifespan Psychology, Max Planck Institute for Human Development, Berlin, Germany; Max Planck, UCL Centre for Computational Psychiatry and Ageing Research, Berlin, Germany; Max Planck, UCL Centre for Computational Psychiatry and Ageing Research, London, United Kingdom
Düzel, Sandra (författare)
Center for Lifespan Psychology, Max Planck Institute for Human Development, Berlin, Germany
Elman, Jeremy (författare)
Center for Behavioral Genomics Twin Research Laboratory, University of California, La Jolla, CA, San Diego, United States; Department of Psychiatry, University of California, La Jolla, San Diego, United States
Franz, Carol (författare)
Center for Behavioral Genomics Twin Research Laboratory, University of California, La Jolla, CA, San Diego, United States; Department of Psychiatry, University of California, La Jolla, San Diego, United States
Håberg, Asta K. (författare)
Department of Medical Imaging, St. Olav's Hospital, Trondheim, Norway; Department of Neuroscience, Norwegian University of Science and Technology (NTNU), Trondheim, Norway
Kietzmann, Tim C. (författare)
MRC Cognition and Brain Sciences Unit, University of Cambridge, United Kingdom; Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, Netherlands
Kievit, Rogier A. (författare)
MRC Cognition and Brain Sciences Unit, University of Cambridge, United Kingdom
Kremen, William S. (författare)
Center of Excellence for Stress and Mental Health, VA San Diego Healthcare System, La Jolla, CA, United States; Center for Behavioral Genomics Twin Research Laboratory, University of California, La Jolla, CA, San Diego, United States; Department of Psychiatry, University of California, La Jolla, San Diego, United States
Krogsrud, Stine K. (författare)
Research Group for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Norway
Kühn, Simone (författare)
Center for Lifespan Psychology, Max Planck Institute for Human Development, Berlin, Germany; Lise Meitner Group for Environmental Neuroscience, Max Planck Institute for Human Development, Berlin, Germany
Lindenberger, Ulman (författare)
Center for Lifespan Psychology, Max Planck Institute for Human Development, Berlin, Germany; Max Planck, UCL Centre for Computational Psychiatry and Ageing Research, Berlin, Germany; Max Planck, UCL Centre for Computational Psychiatry and Ageing Research, London, United Kingdom
Macià, Didac (författare)
Departament de Medicina, Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona, and Institut de Neurociències, Universitat de Barcelona, Spain
Mowinckel, Athanasia M. (författare)
Research Group for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Norway
Nyberg, Lars, 1966- (författare)
Umeå universitet,Umeå centrum för funktionell hjärnavbildning (UFBI)
Panizzon, Matthew S. (författare)
Center for Behavioral Genomics Twin Research Laboratory, University of California, La Jolla, CA, San Diego, United States; Department of Psychiatry, University of California, La Jolla, San Diego, United States
Solé-Padullés, Cristina (författare)
Departament de Medicina, Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona, and Institut de Neurociències, Universitat de Barcelona, Spain
Sørensen, Øystein (författare)
Research Group for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Norway
Westerhausen, René (författare)
Research Group for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Norway
Walhovd, Kristine B. (författare)
Research Group for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Norway; Department of Radiology and Nuclear Medicine, Oslo University Hospital, Oslo, Norway
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 (creator_code:org_t)
eLife Sciences Publications, 2021
2021
Engelska.
Ingår i: eLIFE. - : eLife Sciences Publications. - 2050-084X. ; 10
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • Development and aging of the cerebral cortex show similar topographic organization and are governed by the same genes. It is unclear whether the same is true for subcortical regions, which follow fundamentally different ontogenetic and phylogenetic principles. We tested the hypothesis that genetically governed neurodevelopmental processes can be traced throughout life by assessing to which degree brain regions that develop together continue to change together through life. Analyzing over 6000 longitudinal MRIs of the brain, we used graph theory to identify five clusters of coordinated development, indexed as patterns of correlated volumetric change in brain structures. The clusters tended to follow placement along the cranial axis in embryonic brain development, suggesting continuity from prenatal stages, and correlated with cognition. Across independent longitudinal datasets, we demonstrated that developmental clusters were conserved through life. Twin-based genetic correlations revealed distinct sets of genes governing change in each cluster. Single nucleotide polymorphisms-based analyses of 38127 cross-sectional MRIs showed a similar pattern of genetic volume-volume correlations. In conclusion, coordination of subcortical change adheres to fundamental principles of lifespan continuity and genetic organization.

Ämnesord

MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Neurosciences (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Medical Genetics (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine (hsv//eng)

Nyckelord

Aging
Brain
Development
Genetics
Hippocampus
lifespan
Subcortex

Publikations- och innehållstyp

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