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Sökning: onr:"swepub:oai:DiVA.org:umu-202082" > Deciphering colorec...

Deciphering colorectal cancer genetics through multi-omic analysis of 100,204 cases and 154,587 controls of European and east Asian ancestries

Fernandez-Rozadilla, Ceres (författare)
Edinburgh Cancer Research Centre, Institute of Genomics and Cancer, University of Edinburgh, Edinburgh, United Kingdom; Genomic Medicine Group, Instituto de Investigacion Sanitaria de Santiago, Santiago de Compostela, Spain
Timofeeva, Maria (författare)
Colon Cancer Genetics Group, Medical Research Council Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, United Kingdom; Danish Institute for Advanced Study, Department of Public Health, University of Southern Denmark, Odense, Denmark
Chen, Zhishan (författare)
Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt Epidemiology Center, Vanderbilt University Medical Center, TN, Nashville, United States
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Law, Philip (författare)
Division of Genetics and Epidemiology, Institute of Cancer Research, London, United Kingdom
Thomas, Minta (författare)
Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States
Schmit, Stephanie (författare)
Genomic Medicine Institute, Cleveland Clinic, OH, Cleveland, United States; Population and Cancer Prevention Program, Case Comprehensive Cancer Center, OH, Cleveland, United States
Díez-Obrero, Virginia (författare)
Colorectal Cancer Group, ONCOBELL Program, Bellvitge Biomedical Research Institute, Barcelona, Spain; Oncology Data Analytics Program, Catalan Institute of Oncology, Barcelona, Spain; Consortium for Biomedical Research in Epidemiology and Public Health, Madrid, Madrid, Spain; Department of Clinical Sciences, Faculty of Medicine, University of Barcelona, Barcelona, Spain
Hsu, Li (författare)
Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States; Department of Biostatistics, School of Public Health, University of Washington, WA, Seattle, United States
Fernandez-Tajes, Juan (författare)
Edinburgh Cancer Research Centre, Institute of Genomics and Cancer, University of Edinburgh, Edinburgh, United Kingdom
Palles, Claire (författare)
Institute of Cancer and Genomic Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom
Sherwood, Kitty (författare)
Edinburgh Cancer Research Centre, Institute of Genomics and Cancer, University of Edinburgh, Edinburgh, United Kingdom
Briggs, Sarah (författare)
Department of Public Health, Richard Doll Building, University of Oxford, Oxford, United Kingdom
Svinti, Victoria (författare)
Colon Cancer Genetics Group, Medical Research Council Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, United Kingdom
Donnelly, Kevin (författare)
Colon Cancer Genetics Group, Medical Research Council Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, United Kingdom
Farrington, Susan (författare)
Colon Cancer Genetics Group, Medical Research Council Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, United Kingdom
Blackmur, James (författare)
Colon Cancer Genetics Group, Medical Research Council Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, United Kingdom
Vaughan-Shaw, Peter (författare)
Colon Cancer Genetics Group, Medical Research Council Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, United Kingdom
Shu, Xiao-ou (författare)
Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt Epidemiology Center, Vanderbilt University Medical Center, TN, Nashville, United States
Long, Jirong (författare)
Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt Epidemiology Center, Vanderbilt University Medical Center, TN, Nashville, United States
Cai, Qiuyin (författare)
Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt Epidemiology Center, Vanderbilt University Medical Center, TN, Nashville, United States
Guo, Xingyi (författare)
Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt Epidemiology Center, Vanderbilt University Medical Center, TN, Nashville, United States; Department of Biomedical Informatics, Vanderbilt University School of Medicine, TN, Nashville, United States
Lu, Yingchang (författare)
Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt Epidemiology Center, Vanderbilt University Medical Center, TN, Nashville, United States
Broderick, Peter (författare)
Division of Genetics and Epidemiology, Institute of Cancer Research, London, United Kingdom
Studd, James (författare)
Division of Genetics and Epidemiology, Institute of Cancer Research, London, United Kingdom
Huyghe, Jeroen (författare)
Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States
Harrison, Tabitha (författare)
Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States
Conti, David (författare)
Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States
Dampier, Christopher (författare)
Center for Public Health Genomics, Department of Public Health Sciences, University of Virginia, VA, Charlottesville, United States
Devall, Mathew (författare)
Center for Public Health Genomics, Department of Public Health Sciences, University of Virginia, VA, Charlottesville, United States
Schumacher, Fredrick (författare)
Department of Population and Quantitative Health Sciences, Case Western Reserve University, OH, Cleveland, United States; Case Comprehensive Cancer Center, Case Western Reserve University, OH, Cleveland, United States
Melas, Marilena (författare)
The Steve and Cindy Rasmussen Institute for Genomic Medicine, Nationwide Children’s Hospital, OH, Columbus, United States
Rennert, Gad (författare)
Department of Community Medicine and Epidemiology, Lady Davis Carmel Medical Center, Haifa, Israel; Ruth and Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel; Clalit National Cancer Control Center, Haifa, Israel
Obón-Santacana, Mireia (författare)
Colorectal Cancer Group, ONCOBELL Program, Bellvitge Biomedical Research Institute, Barcelona, Spain; Oncology Data Analytics Program, Catalan Institute of Oncology, Barcelona, Spain; Consortium for Biomedical Research in Epidemiology and Public Health, Madrid, Spain
Martín-Sánchez, Vicente (författare)
Consortium for Biomedical Research in Epidemiology and Public Health, Madrid, Madrid, Spain; Biomedicine Institute, University of León, León, Spain
Moratalla-Navarro, Ferran (författare)
Colorectal Cancer Group, ONCOBELL Program, Bellvitge Biomedical Research Institute, Barcelona, Spain; Oncology Data Analytics Program, Catalan Institute of Oncology, Barcelona, Spain; Consortium for Biomedical Research in Epidemiology and Public Health, Madrid, Madrid, Spain; Department of Clinical Sciences, Faculty of Medicine, University of Barcelona, Barcelona, Spain
Oh, Jae Hwan (författare)
Center for Colorectal Cancer, National Cancer Center Hospital, National Cancer Center, Gyeonggi-do, South Korea
Kim, Jeongseon (författare)
Department of Cancer Biomedical Science, Graduate School of Cancer Science and Policy, National Cancer Center, Gyeonggi-do, South Korea
Jee, Sun Ha (författare)
Department of Epidemiology and Health Promotion, Graduate School of Public Health, Yonsei University, Seoul, South Korea
Jung, Keum Ji (författare)
Department of Epidemiology and Health Promotion, Graduate School of Public Health, Yonsei University, Seoul, South Korea
Kweon, Sun-Seog (författare)
Department of Preventive Medicine, Chonnam National University Medical School, Gwangju, South Korea
Shin, Min-Ho (författare)
Department of Preventive Medicine, Chonnam National University Medical School, Gwangju, South Korea
Shin, Aesun (författare)
Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, South Korea; Cancer Research Institute, Seoul National University, Seoul, South Korea
Ahn, Yoon-Ok (författare)
Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, South Korea
Kim, Dong-Hyun (författare)
Department of Social and Preventive Medicine, Hallym University College of Medicine, Okcheon-dong, South Korea
Oze, Isao (författare)
Division of Cancer Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan
Wen, Wanqing (författare)
Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt Epidemiology Center, Vanderbilt University Medical Center, TN, Nashville, United States
Matsuo, Keitaro (författare)
Division of Molecular and Clinical Epidemiology, Aichi Cancer Center Research Institute, Nagoya, Japan; Department of Epidemiology, Nagoya University Graduate School of Medicine, Nagoya, Japan
Matsuda, Koichi (författare)
Laboratory of Clinical Genome Sequencing, Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, University of Tokyo, Tokyo, Japan
Tanikawa, Chizu (författare)
Laboratory of Genome Technology, Human Genome Center, Institute of Medical Science, University of Tokyo, Tokyo, Japan
Ren, Zefang (författare)
School of Public Health, Sun Yat-sen University, Guangzhou, China
Gao, Yu-Tang (författare)
State Key Laboratory of Oncogenes and Related Genes and Department of Epidemiology, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
Jia, Wei-Hua (författare)
State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat-sen University, Guangzhou, China
Hopper, John (författare)
Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, VIC, Melbourne, Australia; Department of Epidemiology, School of Public Health and Institute of Health and Environment, Seoul National University, Seoul, South Korea
Jenkins, Mark (författare)
Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, VIC, Melbourne, Australia
Win, Aung Ko (författare)
Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, VIC, Melbourne, Australia
Pai, Rish (författare)
Department of Laboratory Medicine and Pathology, Mayo Clinic Arizona, AZ, Scottsdale, United States
Figueiredo, Jane (författare)
Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States; Department of Medicine, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, CA, Los Angeles, United States
Haile, Robert (författare)
Division of Oncology, Department of Medicine, Cedars-Sinai Cancer Research Center for Health Equity, CA, Los Angeles, United States
Gallinger, Steven (författare)
Lunenfeld Tanenbaum Research Institute, Mount Sinai Hospital, University of Toronto, ON, Toronto, Canada
Woods, Michael (författare)
Division of Biomedical Sciences, Memorial University of Newfoundland, ON, St. John, Canada
Newcomb, Polly (författare)
Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States; School of Public Health, University of Washington, WA, Seattle, United States
Duggan, David (författare)
City of Hope National Medical Center, Translational Genomics Research Institute, AZ, Phoenix, United States
Cheadle, Jeremy (författare)
Institute of Medical Genetics, Cardiff University, Cardiff, United Kingdom
Kaplan, Richard (författare)
MRC Clinical Trials Unit, Medical Research Council, Cardiff, United Kingdom
Maughan, Timothy (författare)
MRC Institute for Radiation Oncology, University of Oxford, Oxford, United Kingdom
Kerr, Rachel (författare)
Department of Oncology, University of Oxford, Oxford, United Kingdom
Kerr, David (författare)
Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom
Kirac, Iva (författare)
Department of Surgical Oncology, University Hospital for Tumors, Sestre milosrdnice University Hospital Center, Zagreb, Croatia
Böhm, Jan (författare)
Department of Pathology, Central Finland Health Care District, Jyväskylä, Finland
Mecklin, Lukka-Pekka (författare)
Central Finland Health Care District, Jyväskylä, Finland
Jousilahti, Pekka (författare)
Department of Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland
Knekt, Paul (författare)
Department of Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland
Aaltonen, Lauri (författare)
Department of Medical and Clinical Genetics, University of Helsinki, Helsinki, Finland; Genome-Scale Biology Research Program, University of Helsinki, Helsinki, Finland
Rissanen, Harri (författare)
Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland
Pukkala, Eero (författare)
Finnish Cancer Registry, Institute for Statistical and Epidemiological Cancer Research, Helsinki, Finland; Faculty of Social Sciences, Tampere University, Tampere, Finland
Eriksson, Johan (författare)
Folkhälsan Research Centre, University of Helsinki, Helsinki, Finland; Human Potential Translational Research Programme, National University of Singapore, Singapore, Singapore; Unit of General Practice and Primary Health Care, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
Cajuso, Tatiana (författare)
Department of Medical and Clinical Genetics, University of Helsinki, Helsinki, Finland; Genome-Scale Biology Research Program, University of Helsinki, Helsinki, Finland
Hänninen, Ulrika (författare)
Department of Medical and Clinical Genetics, University of Helsinki, Helsinki, Finland; Genome-Scale Biology Research Program, University of Helsinki, Helsinki, Finland
Kondelin, Johanna (författare)
Department of Medical and Clinical Genetics, University of Helsinki, Helsinki, Finland; Genome-Scale Biology Research Program, University of Helsinki, Helsinki, Finland
Palin, Kimmo (författare)
Department of Medical and Clinical Genetics, University of Helsinki, Helsinki, Finland; Genome-Scale Biology Research Program, University of Helsinki, Helsinki, Finland
Tanskanen, Tomas (författare)
Department of Medical and Clinical Genetics, University of Helsinki, Helsinki, Finland; Genome-Scale Biology Research Program, University of Helsinki, Helsinki, Finland
Renkonen-Sinisalo, Laura (författare)
Department of Surgery, Abdominal Centre, Helsinki University Hospital, Helsinki, Finland
Zanke, Brent (författare)
Department of Oncology, University of Toronto, ON, Toronto, Canada
Männistö, Satu (författare)
Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland
Albanes, Demetrius (författare)
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, MD, Bethesda, United States
Weinstein, Stephanie (författare)
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, MD, Bethesda, United States
Ruiz-Narvaez, Edward (författare)
Department of Nutritional Sciences, School of Public Health, University of Michigan, MI, Ann Arbor, United States
Palmer, Julie (författare)
Slone Epidemiology Center at Boston University, MA, Boston, United States; Department of Medicine, Boston University School of Medicine, MA, Boston, United States
Buchanan, Daniel (författare)
Colorectal Oncogenomics Group, Department of Clinical Pathology, University of Melbourne, VIC, Parkville, Australia; University of Melbourne Centre for Cancer Research, Victorian Comprehensive Cancer Centre, VIC, Parkville, Australia; Genomic Medicine and Family Cancer Clinic, Royal Melbourne Hospital, VIC, Parkville, Australia
Platz, Elizabeth (författare)
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, MD, Baltimore, United States
Visvanathan, Kala (författare)
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, MD, Baltimore, United States
Ulrich, Cornelia (författare)
Huntsman Cancer Institute and Department of Population Health Sciences, University of Utah, UT, Salt Lake City, United States
Siegel, Erin (författare)
Cancer Epidemiology Program, H. Lee Moffitt Cancer Center and Research Institute, FL, Tampa, United States
Brezina, Stefanie (författare)
Institute of Cancer Research, Department of Medicine I, Medical University Vienna, Vienna, Austria
Gsur, Andrea (författare)
Institute of Cancer Research, Department of Medicine I, Medical University Vienna, Vienna, Austria
Campbell, Peter (författare)
Department of Epidemiology and Population Health, Albert Einstein College of Medicine, NY, New York, United States
Chang-Claude, Jenny (författare)
Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany; University Medical Centre Hamburg-Eppendorf, University Cancer Centre Hamburg, Hamburg, Germany
Hoffmeister, Michael (författare)
Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
Brenner, Hermann (författare)
Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany; Division of Preventive Oncology, German Cancer Research Center and National Center for Tumor Diseases, Heidelberg, Germany; German Cancer Consortium, German Cancer Research Center, Heidelberg, Germany
Slattery, Martha (författare)
Department of Internal Medicine, University of Utah, UT, Salt Lake City, United States
Potter, John (författare)
Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States; Research Centre for Hauora and Health, Massey University, Wellington, New Zealand
Tsilidis, Konstantinos (författare)
Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom
Schulze, Matthias (författare)
Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany; Institute of Nutritional Science, University of Potsdam, Potsdam, Germany
Gunter, Marc (författare)
Nutrition and Metabolism Branch, International Agency for Research on Cancer, World Health Organization, Lyon, France
Murphy, Neil (författare)
Nutrition and Metabolism Branch, International Agency for Research on Cancer, World Health Organization, Lyon, France
Castells, Antoni (författare)
Gastroenterology Department, Hospital Clínic, Institut d’Investigacions Biomèdiques August Pi i Sunyer, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, University of Barcelona, Barcelona, Spain
Castellví-Bel, Sergi (författare)
Gastroenterology Department, Hospital Clínic, Institut d’Investigacions Biomèdiques August Pi i Sunyer, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, University of Barcelona, Barcelona, Spain
Moreira, Leticia (författare)
Gastroenterology Department, Hospital Clínic, Institut d’Investigacions Biomèdiques August Pi i Sunyer, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, University of Barcelona, Barcelona, Spain
Arndt, Volker (författare)
Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
Shcherbina, Anna (författare)
Department of Genetics, Stanford University, CA, Stanford, United States
Stern, Mariana (författare)
Department of Population and Public Health Sciences, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States; Jeonnam Regional Cancer Center, Chonnam National University Hwasun Hospital, Hwasun, South Korea
Pardamean, Bens (författare)
Bioinformatics and Data Science Research Center, Bina Nusantara University, Jakarta, Indonesia
Bishop, Timothy (författare)
Leeds Institute of Medical Research at St James’s, University of Leeds, Leeds, United Kingdom
Giles, Graham (författare)
Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, VIC, Melbourne, Australia; Cancer Epidemiology Division, Cancer Council Victoria, VIC, Melbourne, Australia; Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, VIC, Clayton, Australia
Southey, Melissa (författare)
Cancer Epidemiology Division, Cancer Council Victoria, VIC, Melbourne, Australia; Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, VIC, Clayton, Australia; Department of Clinical Pathology, University of Melbourne, VIC, Melbourne, Australia
Idos, Gregory (författare)
Department of Medical Oncology and Center For Precision Medicine, City of Hope National Medical Center, CA, Duarte, United States
McDonnell, Kevin (författare)
Ruth and Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel; Clalit National Cancer Control Center, Haifa, Israel; Department of Medical Oncology and Center For Precision Medicine, City of Hope National Medical Center, CA, Duarte, United States
Abu-Ful, Zomoroda (författare)
Department of Community Medicine and Epidemiology, Lady Davis Carmel Medical Center, Haifa, Israel
Greenson, Joel (författare)
Ruth and Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel; Clalit National Cancer Control Center, Haifa, Israel; Department of Pathology, University of Michigan, MI, Ann Arbor, United States
Shulman, Katerina (författare)
Department of Community Medicine and Epidemiology, Lady Davis Carmel Medical Center, Haifa, Israel
Lejbkowicz, Flavio (författare)
Department of Community Medicine and Epidemiology, Lady Davis Carmel Medical Center, Haifa, Israel; Clalit National Cancer Control Center, Haifa, Israel; Clalit Health Services, Personalized Genomic Service, Lady Davis Carmel Medical Center, Haifa, Israel
Offit, Kenneth (författare)
Clinical Genetics Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, NY, New York, United States; Department of Medicine, Weill Cornell Medical College, NY, New York, United States
Su, Yu-Ru (författare)
Kaiser Permanente Washington Health Research Institute, WA, Seattle, United States
Steinfelder, Robert (författare)
Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States
Keku, Temitope (författare)
Center for Gastrointestinal Biology and Disease, University of North Carolina, NC, Chapel Hill, United States
van Guelpen, Bethany (författare)
Umeå universitet,Wallenberg centrum för molekylär medicin vid Umeå universitet (WCMM),Onkologi
Hudson, Thomas (författare)
Ontario Institute for Cancer Research, ON, Toronto, Canada
Hampel, Heather (författare)
Division of Human Genetics, Department of Internal Medicine, Ohio State University Comprehensive Cancer Center, OH, Columbus, United States
Pearlman, Rachel (författare)
Division of Human Genetics, Department of Internal Medicine, Ohio State University Comprehensive Cancer Center, OH, Columbus, United States
Berndt, Sonja (författare)
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, MD, Bethesda, United States
Hayes, Richard (författare)
Division of Epidemiology, Department of Population Health, New York University School of Medicine, NY, New York, United States
Martinez, Marie Elena (författare)
Population Sciences, Disparities and Community Engagement, University of California San Diego Moores Cancer Center, La Jolla, CA, United States; Department of Family Medicine and Public Health, University of California San Diego, La Jolla, CA, United States
Thomas, Sushma (författare)
Fred Hutchinson Cancer Research Center, WA, Seattle, United States
Corley, Douglas (författare)
Division of Research, Kaiser Permanente Northern California, CA, Oakland, United States; Department of Gastroenterology, Kaiser Permanente Medical Center, CA, San Francisco, United States
Pharoah, Paul (författare)
Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom
Larsson, Susanna (författare)
Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
Yen, Yun (författare)
Taipei Medical University, Taipei, Taiwan
Lenz, Heinz-Josef (författare)
Department of Medicine, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States
White, Emily (författare)
Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States; Department of Epidemiology, University of Washington School of Public Health, WA, Seattle, United States
Li, Li (författare)
Case Comprehensive Cancer Center, Case Western Reserve University, OH, Cleveland, United States
Doheny, Kimberly (författare)
Center for Inherited Disease Research, Department of Genetic Medicine, Johns Hopkins University School of Medicine, MD, Baltimore, United States
Pugh, Elizabeth (författare)
Center for Inherited Disease Research, Department of Genetic Medicine, Johns Hopkins University School of Medicine, MD, Baltimore, United States
Shelford, Tameka (författare)
Center for Inherited Disease Research, Department of Genetic Medicine, Johns Hopkins University School of Medicine, MD, Baltimore, United States
Chan, Andrew (författare)
Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, MA, Boston, United States; Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, MA, Boston, United States; Channing Division of Network Medicine, Brigham and Women’s Hospital and Harvard Medical School, MA, Boston, United States; Broad Institute of Harvard and MIT, MA, Cambridge, United States; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Harvard University, MA, Boston, United States; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Harvard University, MA, Boston, United States
Cruz-Correa, Marcia (författare)
Comprehensive Cancer Center, University of Puerto Rico, San Juan, Puerto Rico
Lindblom, Annika (författare)
Department of Clinical Genetics, Karolinska University Hospital, Stockholm, Sweden; Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
Hunter, David (författare)
Department of Epidemiology, Harvard T.H. Chan School of Public Health, Harvard University, MA, Boston, United States; Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom
Joshi, Amit (författare)
Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, MA, Boston, United States; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Harvard University, MA, Boston, United States
Schafmayer, Clemens (författare)
Department of General Surgery, University Hospital Rostock, Rostock, Germany
Scacheri, Peter (författare)
Department of Genetics and Genome Sciences, Case Western Reserve University, OH, Cleveland, United States
Kundaje, Anshul (författare)
Department of Genetics, Stanford University, CA, Stanford, United States; Department of Computer Science, Stanford University, CA, Stanford, United States
Nickerson, Deborah (författare)
Department of Genome Sciences, University of Washington, WA, Seattle, United States
Schoen, Robert (författare)
Department of Medicine and Epidemiology, University of Pittsburgh Medical Center, PA, Pittsburgh, United States
Hampe, Jochen (författare)
Department of Medicine I, University Hospital Dresden, Technische Universität Dresden, Dresden, Germany
Stadler, Zsofia (författare)
Department of Medicine, Weill Cornell Medical College, NY, New York, United States; Department of Medicine, Memorial Sloan-Kettering Cancer Center, NY, New York, United States
Vodicka, Pavel (författare)
Department of Molecular Biology of Cancer, Institute of Experimental Medicine of the Czech Academy of Sciences, Prague, Czech Republic; Institute of Biology and Medical Genetics, First Faculty of Medicine, Charles University, Prague, Czech Republic; Faculty of Medicine and Biomedical Center in Pilsen, Charles University, Pilsen, Czech Republic
Vodickova, Ludmila (författare)
Department of Molecular Biology of Cancer, Institute of Experimental Medicine of the Czech Academy of Sciences, Prague, Czech Republic; Institute of Biology and Medical Genetics, First Faculty of Medicine, Charles University, Prague, Czech Republic; Faculty of Medicine and Biomedical Center in Pilsen, Charles University, Pilsen, Czech Republic
Vymetalkova, Veronika (författare)
Department of Molecular Biology of Cancer, Institute of Experimental Medicine of the Czech Academy of Sciences, Prague, Czech Republic; Institute of Biology and Medical Genetics, First Faculty of Medicine, Charles University, Prague, Czech Republic; Faculty of Medicine and Biomedical Center in Pilsen, Charles University, Pilsen, Czech Republic
Papadopoulos, Nickolas (författare)
Department of Oncology Ludwig Center at the Sidney Kimmel Cancer Center, Johns Hopkins University School of Medicine, MD, Baltimore, United States; Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, MD, Baltimore, United States; Department of Pathology, Johns Hopkins School of Medicine, MD, Baltimore, United States
Edlund, Chistopher (författare)
Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States
Gauderman, William (författare)
Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States
Thomas, Duncan (författare)
Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States
Shibata, David (författare)
Department of Surgery, University of Tennessee Health Science Center, TN, Memphis, United States
Toland, Amanda (författare)
Departments of Cancer Biology and Genetics and Internal Medicine, Comprehensive Cancer Center, Ohio State University, OH, Columbus, United States
Markowitz, Sanford (författare)
Departments of Medicine and Genetics, Case Comprehensive Cancer Center, Case Western Reserve University and University Hospitals of Cleveland, OH, Cleveland, United States
Kim, Andre (författare)
Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States
Chanock, Stephen (författare)
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, MD, Bethesda, United States
van Duijnhoven, Franzel (författare)
Division of Human Nutrition and Health, Wageningen University and Research, Wageningen, Netherlands
Feskens, Edith (författare)
Division of Human Nutrition, Wageningen University and Research, Wageningen, Netherlands
Sakoda, Lori (författare)
Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States; Division of Research, Kaiser Permanente Northern California, CA, Oakland, United States
Gago-Dominguez, Manuela (författare)
Genomic Medicine Group, Galician Public Foundation of Genomic Medicine, Servicio Galego de Saude, Santiago de Compostela, Spain; Instituto de Investigación Sanitaria de Santiago de Compostela, Santiago de Compostela, Spain
Wolk, Alicja (författare)
Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
Naccarati, Alessio (författare)
Italian Institute for Genomic Medicine, Candiolo Cancer Institute, Turin, Italy; Candiolo Cancer Institute, Candiolo, Italy
Pardini, Barbara (författare)
Italian Institute for Genomic Medicine, Candiolo Cancer Institute, Turin, Italy; Candiolo Cancer Institute, Candiolo, Italy
FitzGerald, Liesel (författare)
Cancer Epidemiology Division, Cancer Council Victoria, VIC, Melbourne, Australia; Menzies Institute for Medical Research, University of Tasmania, TAS, Hobart, Australia
Lee, Soo Chin (författare)
National University Cancer Institute, Singapore, Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore
Ogino, Shuji (författare)
Department of Epidemiology, Harvard T.H. Chan School of Public Health, Harvard University, MA, Boston, United States; Department of Pathology, Brigham and Women’s Hospital, Harvard Medical School, MA, Boston, United States; Cancer Immunology Program, Dana-Farber Harvard Cancer Center, MA, Boston, United States; Broad Institute of MIT and Harvard, MA, Cambridge, United States
Bien, Stephanie (författare)
Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States
Kooperberg, Charles (författare)
Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States
Li, Christopher (författare)
Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States
Lin, Yi (författare)
Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States
Prentice, Ross (författare)
Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States; Department of Biostatistics, University of Washington, WA, Seattle, United States
Qu, Conghui (författare)
Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States
Bézieau, Stéphane (författare)
Service de Génétique Médicale, Centre Hospitalier Universitaire Nantes, Nantes, France
Tangen, Catherine (författare)
SWOG Statistical Center, Fred Hutchinson Cancer Research Center, WA, Seattle, United States
Mardis, Elaine (författare)
Department of Pediatrics, Nationwide Children’s Hospital, The Steve and Cindy Rasmussen Institute for Genomic Medicine, OH, Columbus, United States
Yamaji, Taiki (författare)
Division of Epidemiology, National Cancer Center Institute for Cancer Control, National Cancer Center, Tokyo, Japan
Sawada, Norie (författare)
Division of Cohort Research, National Cancer Center Institute for Cancer Control, National Cancer Center, Tokyo, Japan
Iwasaki, Motoki (författare)
Division of Epidemiology, National Cancer Center Institute for Cancer Control, National Cancer Center, Tokyo, Japan; Division of Cohort Research, National Cancer Center Institute for Cancer Control, National Cancer Center, Tokyo, Japan
Haiman, Christopher (författare)
Department of Preventive Medicine, Center for Genetic Epidemiology, University of Southern California, CA, Los Angeles, United States
Le Marchand, Loic (författare)
Cancer Center, University of Hawaii, HI, Honolulu, United States
Wu, Anna (författare)
Preventative Medicine, University of Southern California, CA, Los Angeles, United States
Qu, Chenxu (författare)
USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States
McNeil, Caroline (författare)
USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States
Coetzee, Gerhard (författare)
Van Andel Research Institute, MI, Grand Rapids, United States
Hayward, Caroline (författare)
MRC Human Genetics Unit, Institute of Genomics and Cancer, University of Edinburgh, Edinburgh, United Kingdom
Deary, Ian (författare)
Lothian Birth Cohorts group, Department of Psychology, University of Edinburgh, Edinburgh, United Kingdom
Harris, Sarah (författare)
Lothian Birth Cohorts group, Department of Psychology, University of Edinburgh, Edinburgh, United Kingdom
Theodoratou, Evropi (författare)
Centre for Global Health, Usher Institute, University of Edinburgh, Edinburgh, United Kingdom
Reid, Stuart (författare)
Colon Cancer Genetics Group, Medical Research Council Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, United Kingdom
Walker, Marion (författare)
Colon Cancer Genetics Group, Medical Research Council Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, United Kingdom
Ooi, Li Yin (författare)
Colon Cancer Genetics Group, Medical Research Council Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, United Kingdom; Department of Pathology, National University Hospital, National University Health System, Singapore, Singapore
Moreno, Victor (författare)
Colorectal Cancer Group, ONCOBELL Program, Bellvitge Biomedical Research Institute, Barcelona, Spain; Oncology Data Analytics Program, Catalan Institute of Oncology, Barcelona, Spain; Consortium for Biomedical Research in Epidemiology and Public Health, Madrid, Madrid, Spain; Department of Clinical Sciences, Faculty of Medicine, University of Barcelona, Barcelona, Spain
Casey, Graham (författare)
Center for Public Health Genomics, Department of Public Health Sciences, University of Virginia, VA, Charlottesville, United States
Gruber, Stephen (författare)
Department of Medical Oncology and Center For Precision Medicine, City of Hope National Medical Center, CA, Duarte, United States
Tomlinson, Ian (författare)
Edinburgh Cancer Research Centre, Institute of Genomics and Cancer, University of Edinburgh, Edinburgh, United Kingdom; Institute of Cancer and Genomic Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom
Zheng, Wei (författare)
Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt Epidemiology Center, Vanderbilt University Medical Center, TN, Nashville, United States
Dunlop, Malcolm (författare)
Colon Cancer Genetics Group, Medical Research Council Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, United Kingdom
Houlston, Richard (författare)
Division of Genetics and Epidemiology, Institute of Cancer Research, London, United Kingdom
Peters, Ulrike (författare)
Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States; Department of Epidemiology, University of Washington, WA, Seattle, United States
visa färre...
 (creator_code:org_t)
2022-12-20
2023
Engelska.
Ingår i: Nature Genetics. - : Nature Publishing Group. - 1061-4036 .- 1546-1718. ; 55, s. 89-99
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • Colorectal cancer (CRC) is a leading cause of mortality worldwide. We conducted a genome-wide association study meta-analysis of 100,204 CRC cases and 154,587 controls of European and east Asian ancestry, identifying 205 independent risk associations, of which 50 were unreported. We performed integrative genomic, transcriptomic and methylomic analyses across large bowel mucosa and other tissues. Transcriptome- and methylome-wide association studies revealed an additional 53 risk associations. We identified 155 high-confidence effector genes functionally linked to CRC risk, many of which had no previously established role in CRC. These have multiple different functions and specifically indicate that variation in normal colorectal homeostasis, proliferation, cell adhesion, migration, immunity and microbial interactions determines CRC risk. Crosstissue analyses indicated that over a third of effector genes most probably act outside the colonic mucosa. Our findings provide insights into colorectal oncogenesis and highlight potential targets across tissues for new CRC treatment and chemoprevention strategies.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Medical Genetics (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
NATURVETENSKAP  -- Biologi -- Utvecklingsbiologi (hsv//swe)
NATURAL SCIENCES  -- Biological Sciences -- Developmental Biology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)

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