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Sökning: onr:"swepub:oai:DiVA.org:umu-205931" > Validation of a gen...

Validation of a genetic-enhanced risk prediction model for colorectal cancer in a large community-based cohort

Su, Yu-Ru (författare)
Biostatistics Unit, Kaiser Permanente Washington Health Research Institute, WA, Seattle, United States; Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States
Sakoda, Lori C. (författare)
Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States; Division of Research, Kaiser Permanente Northern California, CA, Oakland, United States; Department of Health Systems Science, Kaiser Permanente Bernard J. Tyson School of Medicine, CA, Pasadena, United States
Jeon, Jihyoun (författare)
Department of Epidemiology, University of Michigan, MI, Ann Arbor, United States
visa fler...
Thomas, Minta (författare)
Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States
Lin, Yi (författare)
Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States
Schneider, Jennifer L. (författare)
Division of Research, Kaiser Permanente Northern California, CA, Oakland, United States
Udaltsova, Natalia (författare)
Division of Research, Kaiser Permanente Northern California, CA, Oakland, United States
Lee, Jeffrey K. (författare)
Division of Research, Kaiser Permanente Northern California, CA, Oakland, United States; Department of Gastroenterology, Kaiser Permanente San Francisco Medical Center, CA, San Francisco, United States
Lansdorp-Vogelaar, Iris (författare)
Department of Public Health, Erasmus MC, University Medical Center, Rotterdam, Netherlands
Peterse, Elisabeth F P (författare)
Department of Public Health, Erasmus MC, University Medical Center, Rotterdam, Netherlands
Zauber, Ann G. (författare)
Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, NY, United States
Zheng, Jiayin (författare)
Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States
Zheng, Yingye (författare)
Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States
Hauser, Elizabeth (författare)
VA Cooperative Studies Program Epidemiology Center, Durham Veterans Affairs Health Care System, NC, Durham, United States
Baron, John A. (författare)
Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, NC, United States
Barry, Elizabeth L. (författare)
Department of Epidemiology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire
Bishop, D Timothy (författare)
Leeds Institute of Cancer and Pathology, University of Leeds, Leeds, United Kingdom
Brenner, Hermann (författare)
Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany
Buchanan, Daniel D. (författare)
Colorectal Oncogenomics Group, Department of Clinical Pathology, University of Melbourne, VIC, Parkville, Australia
Burnett-Hartman, Andrea (författare)
Institute for Health Research, Kaiser Permanente Colorado, CO, Denver, United States
Campbell, Peter T. (författare)
Behavioral and Epidemiology Research Group, American Cancer Society, Atlanta, Georgia
Casey, Graham (författare)
Center for Public Health Genomics, University of Virginia, VA, Charlottesville, United States
Castellví-Bel, Sergi (författare)
Gastroenterology Department, Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), University of Barcelona, Barcelona, Spain
Chan, Andrew T. (författare)
Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, MA, Boston, United States
Chang-Claude, Jenny (författare)
Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany
Figueiredo, Jane C. (författare)
Department of Medicine, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, CA, Los Angeles, United States
Gallinger, Steven J. (författare)
Lunenfeld Tanenbaum Research Institute, University of Toronto, Mount Sinai Hospital, ON, Toronto, Canada
Giles, Graham G. (författare)
Cancer Epidemiology Division, Cancer Council Victoria, VIC, Melbourne, Australia
Gruber, Stephen B. (författare)
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States; USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States
Gsur, Andrea (författare)
Institute of Cancer Research, Department of Medicine I, Medical University Vienna, Vienna, Austria
Gunter, Marc J. (författare)
Nutrition and Metabolism Section, International Agency for Research on Cancer, World Health Organization, Lyon, France
Hampe, Jochen (författare)
Department of Medicine I, University Hospital Dresden, Technische Universität Dresden (TU Dresden), Dresden, Germany
Hampel, Heather (författare)
Division of Human Genetics, Department of Internal Medicine, Ohio State University Comprehensive Cancer Center, OH, Columbus, United States
Harrison, Tabitha A. (författare)
Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States
Hoffmeister, Michael (författare)
Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany
Hua, Xinwei (författare)
Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States
Huyghe, Jeroen R. (författare)
Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States
Jenkins, Mark A. (författare)
Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, VIC, Melbourne, Australia
Keku, Temitope O. (författare)
Center for Gastrointestinal Biology and Disease, University of North Carolina, Chapel Hill, NC, United States
Marchand, Loic Le (författare)
University of Hawaii Cancer Center, HI, Honolulu, United States
Li, Li (författare)
Department of Family Medicine, University of Virginia, VA, Charlottesville, United States
Lindblom, Annika (författare)
Department of Clinical Genetics, Karolinska University Hospital, Stockholm, Sweden
Moreno, Victor (författare)
Oncology Data Analytics Program, Catalan Institute of Oncology-IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain
Newcomb, Polly A. (författare)
Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States
Pharoah, Paul D P (författare)
Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom
Platz, Elizabeth A. (författare)
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, MD, Baltimore, Liberia
Potter, John D. (författare)
Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States
Qu, Conghui (författare)
Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States
Rennert, Gad (författare)
Department of Community Medicine and Epidemiology, Lady Davis Carmel Medical Center and Technion-Israel Institute of Technology, Haifa, Israel
Schoen, Robert E. (författare)
Department of Medicine and Epidemiology, University of Pittsburgh Medical Center, PA, Pittsburgh, United States
Slattery, Martha L. (författare)
Department of Internal Medicine, University of Utah, UT, Salt Lake City, United States
Song, Mingyang (författare)
Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, MA, Boston, United States
van Duijnhoven, Fränzel J B (författare)
Division of Human Nutrition and Health, Wageningen University & Research, Wageningen, Netherlands
van Guelpen, Bethany (författare)
Umeå universitet,Wallenberg centrum för molekylär medicin vid Umeå universitet (WCMM),Onkologi
Vodicka, Pavel (författare)
Department of Molecular Biology of Cancer, Institute of Experimental Medicine of the Czech Academy of Sciences, Prague, Czech Republic; Biomedical Center, Faculty of Medicine Pilsen, Charles University, Prague, Czech Republic
Wolk, Alicja (författare)
Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
Woods, Michael O. (författare)
Memorial University of Newfoundland, Discipline of Genetics, St. John's, Canada
Wu, Anna H. (författare)
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States
Hayes, Richard B. (författare)
Division of Epidemiology, Department of Population Health, New York University School of Medicine, NY, United States
Peters, Ulrike (författare)
Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States
Corley, Douglas A. (författare)
Division of Research, Kaiser Permanente Northern California, CA, Oakland, United States
Hsu, Li (författare)
Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States
visa färre...
Biostatistics Unit, Kaiser Permanente Washington Health Research Institute, WA, Seattle, United States; Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States; Division of Research, Kaiser Permanente Northern California, CA, Oakland, United States; Department of Health Systems Science, Kaiser Permanente Bernard J Tyson School of Medicine, CA, Pasadena, United States (creator_code:org_t)
American association for cancer research, 2023
2023
Engelska.
Ingår i: Cancer Epidemiology, Biomarkers and Prevention. - : American association for cancer research. - 1055-9965 .- 1538-7755. ; 32:3, s. 353-362
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • BACKGROUND: Polygenic risk scores (PRS) which summarize individuals' genetic risk profile may enhance targeted colorectal cancer screening. A critical step towards clinical implementation is rigorous external validations in large community-based cohorts. This study externally validated a PRS-enhanced colorectal cancer risk model comprising 140 known colorectal cancer loci to provide a comprehensive assessment on prediction performance.METHODS: The model was developed using 20,338 individuals and externally validated in a community-based cohort (n = 85,221). We validated predicted 5-year absolute colorectal cancer risk, including calibration using expected-to-observed case ratios (E/O) and calibration plots, and discriminatory accuracy using time-dependent AUC. The PRS-related improvement in AUC, sensitivity and specificity were assessed in individuals of age 45 to 74 years (screening-eligible age group) and 40 to 49 years with no endoscopy history (younger-age group).RESULTS: In European-ancestral individuals, the predicted 5-year risk calibrated well [E/O = 1.01; 95% confidence interval (CI), 0.91-1.13] and had high discriminatory accuracy (AUC = 0.73; 95% CI, 0.71-0.76). Adding the PRS to a model with age, sex, family and endoscopy history improved the 5-year AUC by 0.06 (P < 0.001) and 0.14 (P = 0.05) in the screening-eligible age and younger-age groups, respectively. Using a risk-threshold of 5-year SEER colorectal cancer incidence rate at age 50 years, adding the PRS had a similar sensitivity but improved the specificity by 11% (P < 0.001) in the screening-eligible age group. In the younger-age group it improved the sensitivity by 27% (P = 0.04) with similar specificity.CONCLUSIONS: The proposed PRS-enhanced model provides a well-calibrated 5-year colorectal cancer risk prediction and improves discriminatory accuracy in the external cohort.IMPACT: The proposed model has potential utility in risk-stratified colorectal cancer prevention.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)

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