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Genome-wide interac...
Genome-wide interaction study with smoking for colorectal cancer risk identifies novel genetic loci related to tumor suppression, inflammation, and immune response
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- Carreras-Torres, Robert (författare)
- Colorectal Cancer Group, ONCOBELL Program, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain; Oncology Data Analytics Program, Catalan Institute of Oncology, L'Hospitalet de Llobregat, Barcelona, Spain; Digestive Diseases and Microbiota Group, Girona Biomedical Research Institute (IDIBGI), Salt, Girona, Spain
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- Kim, Andre E. (författare)
- Division of Biostatistics, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States
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- Lin, Yi (författare)
- Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States
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- Díez-Obrero, Virginia (författare)
- Colorectal Cancer Group, ONCOBELL Program, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain; Oncology Data Analytics Program, Catalan Institute of Oncology, L'Hospitalet de Llobregat, Barcelona, Spain; Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), Madrid, Spain
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- Bien, Stephanie A. (författare)
- Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States
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- Qu, Conghui (författare)
- Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States
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- Wang, Jun (författare)
- Division of Biostatistics, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States
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- Dimou, Niki (författare)
- Nutrition and Metabolism Branch, International Agency for Research on Cancer, Lyon, France
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- Aglago, Elom K. (författare)
- Nutrition and Metabolism Branch, International Agency for Research on Cancer, Lyon, France
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- Albanes, Demetrius (författare)
- Division of Cancer Epidemiology and Genetics, NCI, NIH, MD, Bethesda, Liberia
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- Arndt, Volker (författare)
- Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany
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- Baurley, James W. (författare)
- Bioinformatics and Data Science Research Center, Bina Nusantara University, Jakarta, Indonesia
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- Berndt, Sonja I. (författare)
- Division of Cancer Epidemiology and Genetics, NCI, NIH, MD, Bethesda, Liberia
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- Bézieau, Stéphane (författare)
- Service de Génétique Médicale, Centre Hospitalier Universitaire (CHU) Nantes, Nantes, France
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- Bishop, D Timothy (författare)
- Leeds Institute of Cancer and Pathology, University of Leeds, Leeds, United Kingdom
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- Bouras, Emmanouil (författare)
- Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece
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- Brenner, Hermann (författare)
- Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany; Division of Preventive Oncology, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), Heidelberg, Germany; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany
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- Budiarto, Arif (författare)
- Bioinformatics and Data Science Research Center, Bina Nusantara University, Jakarta, Indonesia
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- Campbell, Peter T. (författare)
- Behavioral and Epidemiology Research Group, American Cancer Society, Atlanta, Georgia
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- Casey, Graham (författare)
- Center for Public Health Genomics, Department of Public Health Sciences, University of Virginia, VA, Charlottesville, United States
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- Chan, Andrew T. (författare)
- Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, MA, Boston, United States
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- Chang-Claude, Jenny (författare)
- Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany
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- Chen, Xuechen (författare)
- Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany
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- Conti, David V. (författare)
- Division of Biostatistics, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States
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- Dampier, Christopher H. (författare)
- Department of General Surgery, University of Virginia School of Medicine, VA, Charlottesville, United States
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- Devall, Matthew A M (författare)
- Center for Public Health Genomics, Department of Public Health Sciences, University of Virginia, VA, Charlottesville, United States
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- Drew, David A. (författare)
- Clinical & Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, MA, Boston, United States
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- Figueiredo, Jane C. (författare)
- Department of Medicine, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, CA, Los Angeles, United States
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- Gallinger, Steven (författare)
- Lunenfeld Tanenbaum Research Institute, University of Toronto, Mount Sinai Hospital, ON, Toronto, Canada
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- Giles, Graham G. (författare)
- Cancer Epidemiology Division, Cancer Council Victoria, VIC, Melbourne, Australia
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- Gruber, Stephen B. (författare)
- Department of Medical Oncology & Therapeutics Research, City of Hope National Medical Center, Duarte, California
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- Gsur, Andrea (författare)
- Institute of Cancer Research, Department of Medicine I, Medical University Vienna, Vienna, Austria
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- Gunter, Marc J. (författare)
- Nutrition and Metabolism Branch, International Agency for Research on Cancer, Lyon, France
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- Harrison, Tabitha A. (författare)
- Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States
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- Hidaka, Akihisa (författare)
- Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States
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- Hoffmeister, Michael (författare)
- Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany
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- Huyghe, Jeroen R. (författare)
- Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States
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- Jenkins, Mark A. (författare)
- Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, VIC, Melbourne, Australia
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- Jordahl, Kristina M. (författare)
- Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States
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- Kawaguchi, Eric (författare)
- Division of Biostatistics, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States
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- Keku, Temitope O. (författare)
- Center for Gastrointestinal Biology and Disease, University of North Carolina, Chapel Hill, NC, United States
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- Kundaje, Anshul (författare)
- Department of Genetics, Department of Computer Science, Stanford University, CA, Stanford, United States
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- Le Marchand, Loic (författare)
- University of Hawaii Cancer Center, HI, Honolulu, United States
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- Lewinger, Juan Pablo (författare)
- Division of Biostatistics, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States
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- Li, Li (författare)
- Department of Family Medicine, University of Virginia, VA, Charlottesville, United States
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- Mahesworo, Bharuno (författare)
- Bioinformatics and Data Science Research Center, Bina Nusantara University, Jakarta, Indonesia
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- Morrison, John L. (författare)
- Division of Biostatistics, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States
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- Murphy, Neil (författare)
- Nutrition and Metabolism Branch, International Agency for Research on Cancer, Lyon, France
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- Nan, Hongmei (författare)
- Department of Epidemiology, Richard M. Fairbanks School of Public Health, IN, Indianapolis, United States
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- Nassir, Rami (författare)
- Department of Pathology, School of Medicine, Umm Al-Qura'a University, Saudi Arabia
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- Newcomb, Polly A. (författare)
- Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States
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- Obón-Santacana, Mireia (författare)
- Colorectal Cancer Group, ONCOBELL Program, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain; Oncology Data Analytics Program, Catalan Institute of Oncology, L'Hospitalet de Llobregat, Barcelona, Spain; Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), Madrid, Spain
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- Ogino, Shuji (författare)
- Program in MPE Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, MA, Boston, United States; Department of Oncologic Pathology, Dana-Farber Cancer Institute, MA, Boston, United States; Department of Epidemiology, Harvard T.H. Chan School of Public Health, MA, Boston, United States; Broad Institute of MIT and Harvard, MA, Cambridge, United States
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- Ose, Jennifer (författare)
- Huntsman Cancer Institute, UT, Salt Lake City, United States; Department of Population Health Sciences, University of Utah, UT, Salt Lake City, United States
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- Pai, Rish K. (författare)
- Department of Laboratory Medicine and Pathology, Mayo Clinic Arizona, AZ, Scottsdale, United States
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- Palmer, Julie R. (författare)
- Slone Epidemiology Center at Boston University, MA, Boston, United States
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- Papadimitriou, Nikos (författare)
- Nutrition and Metabolism Branch, International Agency for Research on Cancer, Lyon, France
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- Pardamean, Bens (författare)
- Bioinformatics and Data Science Research Center, Bina Nusantara University, Jakarta, Indonesia
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- Peoples, Anita R. (författare)
- Huntsman Cancer Institute, UT, Salt Lake City, United States
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- Pharoah, Paul D P (författare)
- Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom
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- Platz, Elizabeth A. (författare)
- Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, MD, Baltimore, Liberia
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- Rennert, Gad (författare)
- Department of Community Medicine and Epidemiology, Lady Davis Carmel Medical Center, Haifa, Israel
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- Ruiz-Narvaez, Edward (författare)
- Department of Nutritional Sciences, University of Michigan School of Public Health, MI, Ann Arbor, United States
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- Sakoda, Lori C. (författare)
- Division of Research, Kaiser Permanente Northern California, CA, Oakland, United States
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- Scacheri, Peter C. (författare)
- Department of Genetics and Genome Sciences, Case Western Reserve University, OH, Cleveland, United States
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- Schmit, Stephanie L. (författare)
- Genomic Medicine Institute, Cleveland Clinic, OH, Cleveland, United States; Population and Cancer Prevention Program, Case Comprehensive Cancer Center, OH, Cleveland, United States
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- Schoen, Robert E. (författare)
- Department of Medicine and Epidemiology, University of Pittsburgh Medical Center, PA, Pittsburgh, United States
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- Shcherbina, Anna (författare)
- Biomedical Informatics Program, Dept. of Biomedical Data Sciences, Stanford University, CA, Stanford, United States
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- Slattery, Martha L. (författare)
- Department of Internal Medicine, University of Utah, UT, Salt Lake City, United States
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- Stern, Mariana C. (författare)
- Division of Biostatistics, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States
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- Su, Yu-Ru (författare)
- Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States
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- Tangen, Catherine M. (författare)
- SWOG Statistical Center, Fred Hutchinson Cancer Research Center, WA, Seattle, United States
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- Thomas, Duncan C. (författare)
- Division of Biostatistics, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States
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- Tian, Yu (författare)
- Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany; School of Public Health, Capital Medical University, Beijing, China
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- Tsilidis, Konstantinos K. (författare)
- Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom
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- Ulrich, Cornelia M. (författare)
- Huntsman Cancer Institute, UT, Salt Lake City, United States; Department of Population Health Sciences, University of Utah, UT, Salt Lake City, United States
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- van Duijnhoven, Fränzel J B (författare)
- Division of Human Nutrition and Health, Wageningen University & Research, Wageningen, Netherlands
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- van Guelpen, Bethany (författare)
- Umeå universitet,Wallenberg centrum för molekylär medicin vid Umeå universitet (WCMM),Onkologi
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- Visvanathan, Kala (författare)
- Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, MD, Baltimore, Liberia
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- Vodicka, Pavel (författare)
- Department of Molecular Biology of Cancer, Institute of Experimental Medicine of the Czech Academy of Sciences, Prague, and Biomedical Center, Medical Faculty, Pilsen, Czech Republic
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- Cenggoro, Tjeng Wawan (författare)
- Bioinformatics and Data Science Research Center, Bina Nusantara University, Jakarta, Indonesia
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- Weinstein, Stephanie J. (författare)
- Division of Cancer Epidemiology and Genetics, NCI, NIH, MD, Bethesda, Liberia
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- White, Emily (författare)
- Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States
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- Wolk, Alicja (författare)
- Karolinska Institutet
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- Woods, Michael O. (författare)
- Memorial University of Newfoundland, Discipline of Genetics, St. John's, Canada
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- Hsu, Li (författare)
- Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States
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- Peters, Ulrike (författare)
- Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States; School of Public Health, University of Washington, WA, Seattle, United States
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- Moreno, Victor (författare)
- Colorectal Cancer Group, ONCOBELL Program, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain; Oncology Data Analytics Program, Catalan Institute of Oncology, L'Hospitalet de Llobregat, Barcelona, Spain; Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), Madrid, Spain; Department of Clinical Sciences, Faculty of Medicine, University of Barcelona, Barcelona, Spain
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- Gauderman, W. James (författare)
- Division of Biostatistics, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States
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(creator_code:org_t)
- American association for cancer research, 2023
- 2023
- Engelska.
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Ingår i: Cancer Epidemiology, Biomarkers and Prevention. - : American association for cancer research. - 1055-9965 .- 1538-7755. ; 32:3, s. 315-328
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- BACKGROUND: Tobacco smoking is an established risk factor for colorectal cancer. However, genetically defined population subgroups may have increased susceptibility to smoking-related effects on colorectal cancer.METHODS: A genome-wide interaction scan was performed including 33,756 colorectal cancer cases and 44,346 controls from three genetic consortia.RESULTS: Evidence of an interaction was observed between smoking status (ever vs. never smokers) and a locus on 3p12.1 (rs9880919, P = 4.58 × 10-8), with higher associated risk in subjects carrying the GG genotype [OR, 1.25; 95% confidence interval (CI), 1.20-1.30] compared with the other genotypes (OR <1.17 for GA and AA). Among ever smokers, we observed interactions between smoking intensity (increase in 10 cigarettes smoked per day) and two loci on 6p21.33 (rs4151657, P = 1.72 × 10-8) and 8q24.23 (rs7005722, P = 2.88 × 10-8). Subjects carrying the rs4151657 TT genotype showed higher risk (OR, 1.12; 95% CI, 1.09-1.16) compared with the other genotypes (OR <1.06 for TC and CC). Similarly, higher risk was observed among subjects carrying the rs7005722 AA genotype (OR, 1.17; 95% CI, 1.07-1.28) compared with the other genotypes (OR <1.13 for AC and CC). Functional annotation revealed that SNPs in 3p12.1 and 6p21.33 loci were located in regulatory regions, and were associated with expression levels of nearby genes. Genetic models predicting gene expression revealed that smoking parameters were associated with lower colorectal cancer risk with higher expression levels of CADM2 (3p12.1) and ATF6B (6p21.33).CONCLUSIONS: Our study identified novel genetic loci that may modulate the risk for colorectal cancer of smoking status and intensity, linked to tumor suppression and immune response.IMPACT: These findings can guide potential prevention treatments.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
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Carreras-Torres, ...
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Kim, Andre E.
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Lin, Yi
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Díez-Obrero, Vir ...
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Bien, Stephanie ...
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Qu, Conghui
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Wang, Jun
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Dimou, Niki
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Aglago, Elom K.
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Albanes, Demetri ...
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Arndt, Volker
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Baurley, James W ...
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Berndt, Sonja I.
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Bézieau, Stéphan ...
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Bishop, D Timoth ...
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Bouras, Emmanoui ...
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Brenner, Hermann
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Budiarto, Arif
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Campbell, Peter ...
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Casey, Graham
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Chan, Andrew T.
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Chang-Claude, Je ...
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Chen, Xuechen
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Conti, David V.
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Dampier, Christo ...
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Devall, Matthew ...
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Drew, David A.
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Figueiredo, Jane ...
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Gallinger, Steve ...
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Giles, Graham G.
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Gruber, Stephen ...
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Gsur, Andrea
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Gunter, Marc J.
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Harrison, Tabith ...
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Hidaka, Akihisa
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Hoffmeister, Mic ...
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Huyghe, Jeroen R ...
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Jenkins, Mark A.
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Jordahl, Kristin ...
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Kawaguchi, Eric
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Keku, Temitope O ...
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Kundaje, Anshul
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Le Marchand, Loi ...
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Lewinger, Juan P ...
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Li, Li
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Mahesworo, Bharu ...
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Morrison, John L ...
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Murphy, Neil
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Nan, Hongmei
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Nassir, Rami
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Newcomb, Polly A ...
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Obón-Santacana, ...
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Ogino, Shuji
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Ose, Jennifer
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Pai, Rish K.
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Palmer, Julie R.
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Papadimitriou, N ...
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Pardamean, Bens
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Peoples, Anita R ...
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Pharoah, Paul D ...
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Platz, Elizabeth ...
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Rennert, Gad
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Ruiz-Narvaez, Ed ...
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Sakoda, Lori C.
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Scacheri, Peter ...
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Schmit, Stephani ...
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Schoen, Robert E ...
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Shcherbina, Anna
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Slattery, Martha ...
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Stern, Mariana C ...
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Su, Yu-Ru
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Tangen, Catherin ...
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Thomas, Duncan C ...
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Tian, Yu
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Tsilidis, Konsta ...
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Ulrich, Cornelia ...
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van Duijnhoven, ...
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van Guelpen, Bet ...
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Visvanathan, Kal ...
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Vodicka, Pavel
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Cenggoro, Tjeng ...
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Weinstein, Steph ...
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White, Emily
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Wolk, Alicja
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Woods, Michael O ...
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Hsu, Li
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Peters, Ulrike
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Moreno, Victor
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Gauderman, W. Ja ...
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