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A Genetic Locus wit...
A Genetic Locus within the FMN1/GREM1 Gene Region Interacts with Body Mass Index in Colorectal Cancer Risk
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- Aglago, Elom K. (författare)
- Department of Epidemiology and Biostatistics, Imperial College London, School of Public Health, London, United Kingdom
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- Kim, Andre (författare)
- Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States
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- Lin, Yi (författare)
- Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States
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visa fler...
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- Qu, Conghui (författare)
- Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States
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- Evangelou, Marina (författare)
- Department of Epidemiology and Biostatistics, Imperial College London, School of Public Health, London, United Kingdom
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- Ren, Yu (författare)
- Department of Epidemiology and Biostatistics, Imperial College London, School of Public Health, London, United Kingdom
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- Morrison, John (författare)
- Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States
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- Albanes, Demetrius (författare)
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, MD, Bethesda, Liberia
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- Arndt, Volker (författare)
- Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany
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- Barry, Elizabeth L. (författare)
- Department of Epidemiology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire
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- Baurley, James W. (författare)
- Bioinformatics and Data Science Research Center, Bina Nusantara University, Jakarta, Indonesia
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- Berndt, Sonja I. (författare)
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, MD, Bethesda, Liberia
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- Bien, Stephanie A. (författare)
- Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States
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- Bishop, D Timothy (författare)
- Leeds Institute of Cancer and Pathology, University of Leeds, Leeds, United Kingdom
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- Bouras, Emmanouil (författare)
- Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece
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- Brenner, Hermann (författare)
- Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany; Division of Preventive Oncology, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), Heidelberg, Germany; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany
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- Buchanan, Daniel D. (författare)
- Colorectal Oncogenomics Group, Department of Clinical Pathology, University of Melbourne, VIC, Parkville, Australia; University of Melbourne Centre for Cancer Research, Victorian Comprehensive Cancer Centre, VIC, Parkville, Australia; Genomic Medicine and Family Cancer Clinic, Royal Melbourne Hospital, VIC, Parkville, Australia
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- Budiarto, Arif (författare)
- Bioinformatics and Data Science Research Center, Bina Nusantara University, Jakarta, Indonesia; Computer Science Department, School of Computer Science, Bina Nusantara University, Jakarta, Indonesia
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- Carreras-Torres, Robert (författare)
- ONCOBELL Program, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain; Digestive Diseases and Microbiota Group, Girona Biomedical Research Institute (IDIBGI), Salt, Girona, Spain
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- Casey, Graham (författare)
- Center for Public Health Genomics, Department of Public Health Sciences, University of Virginia, VA, Charlottesville, United States
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- Cenggoro, Tjeng Wawan (författare)
- Bioinformatics and Data Science Research Center, Bina Nusantara University, Jakarta, Indonesia
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- Chan, Andrew T. (författare)
- Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, MA, Boston, United States; Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, MA, Boston, United States; Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, MA, Boston, United States; Broad Institute of Harvard and MIT, MA, Cambridge, United States; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Harvard University, MA, Boston, United States; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Harvard University, MA, Boston, United States
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- Chang-Claude, Jenny (författare)
- Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany; University Medical Centre Hamburg-Eppendorf, University Cancer Centre Hamburg (UCCH), Hamburg, Germany
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- Chen, Xuechen (författare)
- Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany; Medical Faculty Heidelberg, Heidelberg University, Heidelberg, Germany
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- Conti, David V. (författare)
- Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States
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- Devall, Matthew (författare)
- Department of Family Medicine, University of Virginia, VA, Charlottesville, United States
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- Diez-Obrero, Virginia (författare)
- ONCOBELL Program, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain; Unit of Biomarkers and Susceptibility (UBS), Oncology Data Analytics Program (ODAP), Catalan Institute of Oncology (ICO), L'Hospitalet del Llobregat, Barcelona, Spain; Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), Madrid, Spain; Department of Clinical Sciences, Faculty of Medicine, University of Barcelona, Barcelona, Spain; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark
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- Dimou, Niki (författare)
- Nutrition and Metabolism Branch, International Agency for Research on Cancer, World Health Organization, Lyon, France
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- Drew, David (författare)
- Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, MA, Boston, United States
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- Figueiredo, Jane C. (författare)
- Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States; Department of Medicine, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, CA, Los Angeles, United States
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- Gallinger, Steven (författare)
- Lunenfeld Tanenbaum Research Institute, University of Toronto, Mount Sinai Hospital, ON, Toronto, Canada
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- Giles, Graham G. (författare)
- Cancer Epidemiology Division, Cancer Council Victoria, VIC, Melbourne, Australia; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, Australia; Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, VIC, Clayton, Australia
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- Gruber, Stephen B. (författare)
- Department of Medical Oncology & Therapeutics Research, City of Hope National Medical Center
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- Gsur, Andrea (författare)
- Center for Cancer Research, Medical University of Vienna, Vienna, Austria
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- Gunter, Marc J. (författare)
- Nutrition and Metabolism Branch, International Agency for Research on Cancer, World Health Organization, Lyon, France
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- Hampel, Heather (författare)
- Department of Medical Oncology & Therapeutics Research, City of Hope National Medical Center
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- Harlid, Sophia, 1978- (författare)
- Umeå universitet,Onkologi
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- Hidaka, Akihisa (författare)
- Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States
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- Harrison, Tabitha A. (författare)
- Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States
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- Hoffmeister, Michael (författare)
- Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany
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- Huyghe, Jeroen R. (författare)
- Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States
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- Jenkins, Mark A. (författare)
- Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, Australia
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- Jordahl, Kristina (författare)
- Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States
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- Joshi, Amit D. (författare)
- Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, MA, Boston, United States; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Harvard University, MA, Boston, United States
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- Kawaguchi, Eric S. (författare)
- Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States
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- Keku, Temitope O. (författare)
- Center for Gastrointestinal Biology and Disease, University of North Carolina, Chapel Hill, NC, United States
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- Kundaje, Anshul (författare)
- Department of Genetics, Stanford University, CA, Stanford, United States; Department of Computer Science, Stanford University, CA, Stanford, United States
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- Larsson, Susanna C. (författare)
- Karolinska Institutet
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- Marchand, Loic Le (författare)
- University of Hawaii Cancer Center, HI, Honolulu, United States
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- Lewinger, Juan Pablo (författare)
- Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States
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- Li, Li (författare)
- Department of Family Medicine, University of Virginia, VA, Charlottesville, United States
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- Lynch, Brigid M. (författare)
- Cancer Epidemiology Division, Cancer Council Victoria, VIC, Melbourne, Australia; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, Australia; Physical Activity Laboratory, Baker Heart and Diabetes Institute, Melbourne, Australia
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- Mahesworo, Bharuno (författare)
- Bioinformatics and Data Science Research Center, Bina Nusantara University, Jakarta, Indonesia
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- Mandic, Marko (författare)
- Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany; Medical Faculty Heidelberg, Heidelberg University, Heidelberg, Germany
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- Obón-Santacana, Mireia (författare)
- ONCOBELL Program, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain; Unit of Biomarkers and Susceptibility (UBS), Oncology Data Analytics Program (ODAP), Catalan Institute of Oncology (ICO), L'Hospitalet del Llobregat, Barcelona, Spain; Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), Madrid, Spain
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- Moreno, Victor (författare)
- ONCOBELL Program, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain; Unit of Biomarkers and Susceptibility (UBS), Oncology Data Analytics Program (ODAP), Catalan Institute of Oncology (ICO), L'Hospitalet del Llobregat, Barcelona, Spain; Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), Madrid, Spain; Department of Clinical Sciences, Faculty of Medicine, University of Barcelona, Barcelona, Spain
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- Murphy, Neil (författare)
- Nutrition and Metabolism Branch, International Agency for Research on Cancer, World Health Organization, Lyon, France
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- Nan, Hongmei (författare)
- Department of Epidemiology, Richard M. Fairbanks School of Public Health, IN, Indianapolis, United States; IU Melvin and Bren Simon Cancer Center, Indiana University, IN, Indianapolis, United States
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- Nassir, Rami (författare)
- Department of Pathology, School of Medicine, Umm Al-Qura'a University, Mecca, Saudi Arabia
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- Newcomb, Polly A. (författare)
- Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States; Department of Epidemiology, University of Washington School of Public Health, WA, Seattle, United States
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- Ogino, Shuji (författare)
- Broad Institute of Harvard and MIT, MA, Cambridge, United States; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Harvard University, MA, Boston, United States; Program in MPE Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, MA, Boston, United States; Department of Oncologic Pathology, Dana-Farber Cancer Institute, MA, Boston, United States
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- Ose, Jennifer (författare)
- Huntsman Cancer Institute, UT, Salt Lake City, United States; Department of Population Health Sciences, University of Utah, UT, Salt Lake City, United States
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- Pai, Rish K. (författare)
- Department of Laboratory Medicine and Pathology, Mayo Clinic Arizona, AZ, Scottsdale, United States
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- Palmer, Julie R. (författare)
- Department of Medicine, Boston University School of Medicine, Slone Epidemiology Center, Boston University, MA, Boston, United States
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- Papadimitriou, Nikos (författare)
- Nutrition and Metabolism Branch, International Agency for Research on Cancer, World Health Organization, Lyon, France
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- Pardamean, Bens (författare)
- Bioinformatics and Data Science Research Center, Bina Nusantara University, Jakarta, Indonesia
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- Peoples, Anita R. (författare)
- Huntsman Cancer Institute, UT, Salt Lake City, United States; Department of Population Health Sciences, University of Utah, UT, Salt Lake City, United States
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- Platz, Elizabeth A. (författare)
- Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, MD, Baltimore, Liberia
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- Potter, John D. (författare)
- Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States; Department of Epidemiology, University of Washington School of Public Health, WA, Seattle, United States; Research Centre for Hauora and Health, Massey University, Wellington, New Zealand
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- Prentice, Ross L. (författare)
- Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States
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- Rennert, Gad (författare)
- Department of Community Medicine and Epidemiology, Lady Davis Carmel Medical Center, Haifa, Israel; Ruth and Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel; Clalit National Cancer Control Center, Haifa, Israel
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- Ruiz-Narvaez, Edward (författare)
- Department of Nutritional Sciences, University of Michigan School of Public Health, MI, Ann Arbor, United States
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- Sakoda, Lori C. (författare)
- Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States; Division of Research, Kaiser Permanente Northern California, CA, Oakland, United States
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- Scacheri, Peter C. (författare)
- Department of Genetics and Genome Sciences, Case Western Reserve University, OH, Cleveland, United States
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- Schmit, Stephanie L. (författare)
- Genomic Medicine Institute, Cleveland Clinic, OH, Cleveland, United States
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- Schoen, Robert E. (författare)
- Department of Medicine and Epidemiology, University of Pittsburgh Medical Center, PA, Pittsburgh, United States
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- Shcherbina, Anna (författare)
- Department of Genetics, Stanford University, CA, Stanford, United States; Department of Computer Science, Stanford University, CA, Stanford, United States
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- Slattery, Martha L. (författare)
- Department of Internal Medicine, University of Utah, UT, Salt Lake City, United States
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- Stern, Mariana C. (författare)
- Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States
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- Su, Yu-Ru (författare)
- Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States
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- Tangen, Catherine M. (författare)
- SWOG Statistical Center, Fred Hutchinson Cancer Research Center, WA, Seattle, United States
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- Thibodeau, Stephen N. (författare)
- Division of Laboratory Genetics, Department of Laboratory Medicine and Pathology, Mayo Clinic, MN, Rochester, United States
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- Thomas, Duncan C. (författare)
- Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States
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- Tian, Yu (författare)
- Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany; School of Public Health, Capital Medical University, Beijing, China
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- Ulrich, Cornelia M. (författare)
- Huntsman Cancer Institute, UT, Salt Lake City, United States; Department of Population Health Sciences, University of Utah, UT, Salt Lake City, United States
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- van Duijnhoven, Franzel Jb (författare)
- Division of Human Nutrition and Health, Wageningen University & Research, Wageningen, Netherlands
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- van Guelpen, Bethany (författare)
- Umeå universitet,Wallenberg centrum för molekylär medicin vid Umeå universitet (WCMM),Onkologi
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- Visvanathan, Kala (författare)
- Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, MD, Baltimore, Liberia
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- Vodicka, Pavel (författare)
- Department of Molecular Biology of Cancer, Institute of Experimental Medicine of the Czech Academy of Sciences, Prague, Czech Republic; Institute of Biology and Medical Genetics, First Faculty of Medicine, Charles University, Prague, Czech Republic; Faculty of Medicine and Biomedical Center in Pilsen, Charles University, Pilsen, Czech Republic
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- Wang, Jun (författare)
- Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States
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- White, Emily (författare)
- Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States; Department of Epidemiology, University of Washington School of Public Health, WA, Seattle, United States
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- Wolk, Alicja (författare)
- Karolinska Institutet
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- Woods, Michael O. (författare)
- Memorial University of Newfoundland, Discipline of Genetics, St. John's, Canada
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- Wu, Anna H. (författare)
- Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States
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- Zemlianskaia, Natalia (författare)
- Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States
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- Hsu, Li (författare)
- Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States; Department of Biostatistics, University of Washington, WA, Seattle, United States
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- Gauderman, W James (författare)
- Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States
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- Peters, Ulrike (författare)
- Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States; Department of Epidemiology, University of Washington School of Public Health, WA, Seattle, United States
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- Tsilidis, Konstantinos K. (författare)
- Department of Epidemiology and Biostatistics, Imperial College London, School of Public Health, London, United Kingdom; Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece
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- Campbell, Peter T. (författare)
- Department of Epidemiology and Population Health, Albert Einstein College of Medicine, NY, Bronx, United States
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(creator_code:org_t)
- American Association For Cancer Research (AACR), 2023
- 2023
- Engelska.
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Ingår i: Cancer Research. - : American Association For Cancer Research (AACR). - 0008-5472 .- 1538-7445. ; 83:15, s. 2572-2583
- Relaterad länk:
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https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Colorectal cancer risk can be impacted by genetic, environmental, and lifestyle factors, including diet and obesity. Gene-environment interactions (G × E) can provide biological insights into the effects of obesity on colorectal cancer risk. Here, we assessed potential genome-wide G × E interactions between body mass index (BMI) and common SNPs for colorectal cancer risk using data from 36,415 colorectal cancer cases and 48,451 controls from three international colorectal cancer consortia (CCFR, CORECT, and GECCO). The G × E tests included the conventional logistic regression using multiplicative terms (one degree of freedom, 1DF test), the two-step EDGE method, and the joint 3DF test, each of which is powerful for detecting G × E interactions under specific conditions. BMI was associated with higher colorectal cancer risk. The two-step approach revealed a statistically significant G×BMI interaction located within the Formin 1/Gremlin 1 (FMN1/GREM1) gene region (rs58349661). This SNP was also identified by the 3DF test, with a suggestive statistical significance in the 1DF test. Among participants with the CC genotype of rs58349661, overweight and obesity categories were associated with higher colorectal cancer risk, whereas null associations were observed across BMI categories in those with the TT genotype. Using data from three large international consortia, this study discovered a locus in the FMN1/GREM1 gene region that interacts with BMI on the association with colorectal cancer risk. Further studies should examine the potential mechanisms through which this locus modifies the etiologic link between obesity and colorectal cancer.SIGNIFICANCE: This gene-environment interaction analysis revealed a genetic locus in FMN1/GREM1 that interacts with body mass index in colorectal cancer risk, suggesting potential implications for precision prevention strategies.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
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Aglago, Elom K.
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Kim, Andre
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Lin, Yi
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Qu, Conghui
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Evangelou, Marin ...
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Ren, Yu
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visa fler...
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Morrison, John
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Albanes, Demetri ...
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Arndt, Volker
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Barry, Elizabeth ...
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Baurley, James W ...
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Berndt, Sonja I.
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Bien, Stephanie ...
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Bishop, D Timoth ...
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Bouras, Emmanoui ...
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Brenner, Hermann
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Buchanan, Daniel ...
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Budiarto, Arif
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Carreras-Torres, ...
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Casey, Graham
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Cenggoro, Tjeng ...
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Chan, Andrew T.
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Chang-Claude, Je ...
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Chen, Xuechen
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Conti, David V.
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Devall, Matthew
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Diez-Obrero, Vir ...
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Dimou, Niki
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Drew, David
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Figueiredo, Jane ...
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Gallinger, Steve ...
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Giles, Graham G.
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Gruber, Stephen ...
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Gsur, Andrea
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Gunter, Marc J.
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Hampel, Heather
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Harlid, Sophia, ...
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Hidaka, Akihisa
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Harrison, Tabith ...
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Hoffmeister, Mic ...
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Huyghe, Jeroen R ...
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Jenkins, Mark A.
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Jordahl, Kristin ...
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Joshi, Amit D.
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Kawaguchi, Eric ...
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Keku, Temitope O ...
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Kundaje, Anshul
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Larsson, Susanna ...
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Marchand, Loic L ...
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Lewinger, Juan P ...
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Li, Li
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Lynch, Brigid M.
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Mahesworo, Bharu ...
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Mandic, Marko
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Obón-Santacana, ...
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Moreno, Victor
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Murphy, Neil
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Nan, Hongmei
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Nassir, Rami
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Newcomb, Polly A ...
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Ogino, Shuji
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Ose, Jennifer
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Pai, Rish K.
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Palmer, Julie R.
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Papadimitriou, N ...
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Pardamean, Bens
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Peoples, Anita R ...
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Platz, Elizabeth ...
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Potter, John D.
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Prentice, Ross L ...
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Rennert, Gad
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Ruiz-Narvaez, Ed ...
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Sakoda, Lori C.
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Scacheri, Peter ...
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Schmit, Stephani ...
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Schoen, Robert E ...
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Shcherbina, Anna
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Slattery, Martha ...
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Stern, Mariana C ...
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Su, Yu-Ru
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Tangen, Catherin ...
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Thibodeau, Steph ...
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Thomas, Duncan C ...
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Tian, Yu
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Ulrich, Cornelia ...
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van Duijnhoven, ...
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van Guelpen, Bet ...
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Visvanathan, Kal ...
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Vodicka, Pavel
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Wang, Jun
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White, Emily
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Wolk, Alicja
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Woods, Michael O ...
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Wu, Anna H.
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Zemlianskaia, Na ...
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Hsu, Li
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Gauderman, W Jam ...
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Peters, Ulrike
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Tsilidis, Konsta ...
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Campbell, Peter ...
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Umeå universitet
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