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Body mass index, triglyceride-glucose index, and prostate cancer death : a mediation analysis in eight European cohorts

Fritz, Josef (författare)
Register-based epidemiology,LUCC: Lund University Cancer Centre,Registerbaserad epidemiologi - Stocks,LUCC: Lunds universitets cancercentrum,Department of Translational Medicine, Lund University, Malmö, Sweden; Institute of Medical Statistics and Informatics, Medical University of Innsbruck, Innsbruck, Austria,Medical University of Innsbruck,Lund Univ, Dept Translat Med, Malmö, Sweden.;Med Univ Innsbruck, Dept Med Stat & Informat, Innsbruck, Austria.
Jochems, Sylvia H. J. (författare)
Register-based epidemiology,LUCC: Lund University Cancer Centre,Registerbaserad epidemiologi - Stocks,LUCC: Lunds universitets cancercentrum,Department of Clinical Sciences Lund, Lund University, Lund, Sweden,Lund Univ, Dept Clin Sci Lund, Lund, Sweden.
Bjørge, Tone (författare)
University of Bergen,Cancer Registry of Norway, Institute of Population-Based Cancer Research,Cancer Registry of Norway Institute of Population-Based Cancer Research,Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway; Cancer Registry of Norway, Oslo, Norway,Cancer Registry of Norway, Institute of Population-Based Cancer Research,Univ Bergen, Dept Global Publ Hlth & Primary Care, Bergen, Norway.;Canc Registry Norway, Oslo, Norway.
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Wood, Angela M. (författare)
Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom,Univ Cambridge, Dept Publ Hlth & Primary Care, Cambridge, England.
Häggström, Christel (författare)
Umeå universitet,Lund University,Umeå University,Institutionen för folkhälsa och klinisk medicin,Northern Registry Centre,Umeå Univ, Northern Registry Ctr, Dept Publ Hlth & Clin Med, Umeå, Sweden.
Ulmer, Hanno (författare)
Medical University of Innsbruck,Institute of Medical Statistics and Informatics, Medical University of Innsbruck, Innsbruck, Austria; Agency for Preventive and Social Medicine (aks), Bregenz, Austria,Med Univ Innsbruck, Dept Med Stat & Informat, Innsbruck, Austria.;Agcy Prevent & Social Med Aks, Bregenz, Austria.
Nagel, Gabriele (författare)
University of Ulm,Agency for Preventive and Social Medicine (aks), Bregenz, Austria; Institute of Epidemiology and Medical Biometry, Ulm University, Ulm, Germany,Agcy Prevent & Social Med Aks, Bregenz, Austria.;Ulm Univ, Inst Epidemiol & Med Biometry, Ulm, Germany.
Zitt, Emanuel (författare)
Landeskrankenhaus Feldkirch,Vorarlberg Institute for Vascular Investigation and Treatment,,Agency for Preventive and Social Medicine (aks), Bregenz, Austria; Department of Internal Medicine 3, LKH Feldkirch, Feldkirch, Austria; Vorarlberg Institute for Vascular Investigation and Treatment (VIVIT), Feldkirch, Austria,Agcy Prevent & Social Med Aks, Bregenz, Austria.;LKH Feldkirch, Dept Internal Med 3, Feldkirch, Austria.;Vorarlberg Inst Vasc Invest & Treatment VIVIT, Feldkirch, Austria.
Engeland, Anders (författare)
University of Bergen,Norwegian Institute of Public Health,Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway; Department of Chronic Diseases, Norwegian Institute of Public Health, Bergen, Norway,Univ Bergen, Dept Global Publ Hlth & Primary Care, Bergen, Norway.;Norwegian Inst Publ Hlth, Dept Chron Dis, Oslo, Norway.
Harlid, Sophia, 1978- (författare)
Umeå universitet,Onkologi,Umeå University,Umeå Univ, Dept Radiat Sci, Oncol, Umeå, Sweden.
Drake, Isabel (författare)
Diabetes - Cardiovascular Disease,EpiHealth: Epidemiology for Health,EXODIAB: Excellence of Diabetes Research in Sweden,LUCC: Lund University Cancer Centre,Diabetes - kardiovaskulär sjukdom,LUCC: Lunds universitets cancercentrum,Department of Clinical Sciences Malmö, Lund University, Malmö, Sweden,Lund Univ, Dept Clin Sci Malmö, Malmö, Sweden.
Stattin, Pär (författare)
Uppsala universitet,Urologkirurgi
Stocks, Tanja (författare)
Register-based epidemiology,EpiHealth: Epidemiology for Health,LUCC: Lund University Cancer Centre,Registerbaserad epidemiologi - Stocks,LUCC: Lunds universitets cancercentrum,Department of Translational Medicine, Lund University, Malmö, Sweden; Department of Clinical Sciences Lund, Lund University, Lund, Sweden,Lund Univ, Dept Translat Med, Malmö, Sweden.;Lund Univ, Dept Clin Sci Lund, Lund, Sweden.
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 (creator_code:org_t)
2023-12-12
2024
Engelska 9
Ingår i: British Journal of Cancer. - : Nature Publishing Group. - 0007-0920 .- 1532-1827. ; 130:2, s. 9
Relaterad länk:
https://doi.org/10.1... (free)
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https://umu.diva-por... (primary) (Raw object)
https://uu.diva-port... (primary) (Raw object)
https://doi.org/10.1...
https://urn.kb.se/re...
https://urn.kb.se/re...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
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  • Background: Insulin resistance is a hypothesised biological mechanism linking obesity with prostate cancer (PCa) death. Data in support of this hypothesis is limited. Methods: We included 259,884 men from eight European cohorts, with 11,760 incident PCa’s and 1784 PCa deaths during follow-up. We used the triglyceride-glucose (TyG) index as indicator of insulin resistance. We analysed PCa cases with follow-up from PCa diagnosis, and the full cohort with follow-up from the baseline cancer-free state, thus incorporating both PCa incidence and death. We calculated hazard ratios (HR) and the proportion of the total effect of body mass index (BMI) on PCa death mediated through TyG index. Results: In the PCa-case-only analysis, baseline TyG index was positively associated with PCa death (HR per 1-standard deviation: 1.11, 95% confidence interval (CI); 1.01–1.22), and mediated a substantial proportion of the baseline BMI effect on PCa death (HRtotal effect per 5-kg/m2 BMI: 1.24; 1.14–1.35, of which 28%; 4%–52%, mediated). In contrast, in the full cohort, the TyG index was not associated with PCa death (HR: 1.03; 0.94-1.13), hence did not substantially mediate the effect of BMI on PCa death. Conclusions: Insulin resistance could be an important pathway through which obesity accelerates PCa progression to death.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine (hsv//eng)

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