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Sökning: onr:"swepub:oai:DiVA.org:umu-225944" > Two genome-wide int...

Two genome-wide interaction loci modify the association of nonsteroidal anti-inflammatory drugs with colorectal cancer

Drew, David A. (författare)
Clinical & Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, MA, Boston, United States; Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, MA, Boston, United States
Kim, Andre E. (författare)
Division of Biostatistics, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States
Lin, Yi (författare)
Public Health Sciences Division, Fred Hutchinson Cancer Center, WA, Seattle, United States
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Qu, Conghui (författare)
Public Health Sciences Division, Fred Hutchinson Cancer Center, WA, Seattle, United States
Morrison, John (författare)
Division of Biostatistics, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States
Lewinger, Juan Pablo (författare)
Division of Biostatistics, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States
Kawaguchi, Eric (författare)
Division of Biostatistics, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States
Wang, Jun (författare)
Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States
Fu, Yubo (författare)
Division of Biostatistics, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States
Zemlianskaia, Natalia (författare)
Division of Biostatistics, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States
Díez-Obrero, Virginia (författare)
Colorectal Cancer Group, ONCOBELL Program, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain; Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), Madrid, Spain; Department of Clinical Sciences, Faculty of Medicine, University of Barcelona, Barcelona, Spain
Bien, Stephanie A. (författare)
Public Health Sciences Division, Fred Hutchinson Cancer Center, WA, Seattle, United States
Dimou, Niki (författare)
Nutrition and Metabolism Branch, International Agency for Research on Cancer, World Health Organization, Lyon, France
Albanes, Demetrius (författare)
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, MD, Bethesda, United States
Baurley, James W. (författare)
Bioinformatics and Data Science Research Center, Bina Nusantara University, Jakarta, Indonesia
Wu, Anna H. (författare)
Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States
Buchanan, Daniel D. (författare)
Colorectal Oncogenomics Group, Department of Clinical Pathology, University of Melbourne, Parkville, United States; University of Melbourne Centre for Cancer Research, Victorian Comprehensive Cancer Centre, Parkville, United States; Genomic Medicine and Family Cancer Clinic, Royal Melbourne Hospital, VIC, Parkville, Australia
Potter, John D. (författare)
Public Health Sciences Division, Fred Hutchinson Cancer Center, WA, Seattle, United States; Research Centre for Hauora and Health, Massey University, Wellington, New Zealand
Prentice, Ross L. (författare)
Public Health Sciences Division, Fred Hutchinson Cancer Center, WA, Seattle, United States
Harlid, Sophia, 1978- (författare)
Umeå universitet,Onkologi
Arndt, Volker (författare)
Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany
Barry, Elizabeth L. (författare)
Department of Epidemiology, Geisel School of Medicine at Dartmouth, Hanover, NH, USA
Berndt, Sonja I. (författare)
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, MD, Bethesda, United States
Bouras, Emmanouil (författare)
Laboratory of Hygiene, Social & Preventive Medicine and Medical Statistics, Department of Medicine, School of Health Sciences, Aristotle University of Thessaloniki, Thessaloniki, Greece
Brenner, Hermann (författare)
Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany; Division of Preventive Oncology, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), Heidelberg, Germany; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany
Budiarto, Arif (författare)
Bioinformatics and Data Science Research Center, Bina Nusantara University, Jakarta, Indonesia
Burnett-Hartman, Andrea (författare)
Institute for Health Research, Kaiser Permanente Colorado, CO, Denver, United States
Campbell, Peter T. (författare)
Department of Epidemiology and Population Health, Albert Einstein College of Medicine, NY, Bronx, United States
Carreras-Torres, Robert (författare)
Colorectal Cancer Group, ONCOBELL Program, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain; Digestive Diseases and Microbiota Group, Girona Biomedical Research Institute (IDIBGI), Salt, 17190 Girona, Spain
Casey, Graham (författare)
Center for Public Health Genomics, University of Virginia, VA, Charlottesville, United States
Chang-Claude, Jenny (författare)
Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany; University Medical Centre Hamburg-Eppendorf, University Cancer Centre Hamburg (UCCH), Hamburg, Germany
Conti, David V. (författare)
Division of Biostatistics, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States
Devall, Matthew A M (författare)
Department of Family Medicine, University of Virginia, VA, Charlottesville, United States
Figueiredo, Jane C. (författare)
Division of Biostatistics, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States; Department of Medicine, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, CA, Los Angeles, United States
Gruber, Stephen B. (författare)
Department of Medical Oncology & Therapeutics Research, City of Hope National Medical Center, Duarte, CA, USA; Center for Precision Medicine, City of Hope National Medical Center, Duarte, CA, USA
Gsur, Andrea (författare)
Center for Cancer Research, Medical University Vienna, Vienna, Austria
Gunter, Marc J. (författare)
Nutrition and Metabolism Branch, International Agency for Research on Cancer, World Health Organization, Lyon, France; Department of Epidemiology and Biostatistics, Imperial College London, School of Public Health, London, United Kingdom
Harrison, Tabitha A. (författare)
Public Health Sciences Division, Fred Hutchinson Cancer Center, WA, Seattle, United States
Hidaka, Akihisa (författare)
Public Health Sciences Division, Fred Hutchinson Cancer Center, WA, Seattle, United States
Hoffmeister, Michael (författare)
Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany
Huyghe, Jeroen R. (författare)
Public Health Sciences Division, Fred Hutchinson Cancer Center, WA, Seattle, United States
Jenkins, Mark A. (författare)
Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, VIC, Melbourne, Australia
Jordahl, Kristina M. (författare)
Public Health Sciences Division, Fred Hutchinson Cancer Center, WA, Seattle, United States; Department of Epidemiology, School of Public Health, University of Washington, WA, Seattle, United States
Kundaje, Anshul (författare)
Department of Genetics, Stanford University, CA, Stanford, United States; Department of Computer Science, Stanford University, CA, Stanford, United States
Le Marchand, Loic (författare)
University of Hawaii Cancer Center, HI, Honolulu, United States
Li, Li (författare)
Department of Family Medicine, University of Virginia, VA, Charlottesville, United States; UVA Comprehensive Cancer Center, VA, Charlottesville, United States
Lynch, Brigid M. (författare)
Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, VIC, Melbourne, Australia; Cancer Epidemiology Division, Cancer Council Victoria, VIC, Melbourne, Australia
Murphy, Neil (författare)
Nutrition and Metabolism Branch, International Agency for Research on Cancer, World Health Organization, Lyon, France
Nassir, Rami (författare)
Department of Pathology, School of Medicine, Umm Al-Qura'a University, Mecca, Saudi Arabia
Newcomb, Polly A. (författare)
Public Health Sciences Division, Fred Hutchinson Cancer Center, WA, Seattle, United States; School of Public Health, University of Washington, WA, Seattle, United States
Newton, Christina C. (författare)
Department of Population Science, American Cancer Society, GA, Atlanta, United States
Obón-Santacana, Mireia (författare)
Colorectal Cancer Group, ONCOBELL Program, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain; Unit of Biomarkers and Susceptibility (UBS), Oncology Data Analytics Program (ODAP), Catalan Institute of Oncology (ICO), L'Hospitalet del Llobregat, Barcelona, Spain; Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), Madrid, Spain
Ogino, Shuji (författare)
Department of Epidemiology, Harvard T.H. Chan School of Public Health, Harvard University, MA, Boston, United States; Program in MPE Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women's Hospital, MA, Boston, United States; Harvard Medical School, MA, Boston, United States; Broad Institute of MIT and Harvard, MA, Cambridge, United States
Ose, Jennifer (författare)
Huntsman Cancer Institute, UT, Salt Lake City, United States; Department of Population Health Sciences, University of Utah, UT, Salt Lake City, United States
Pai, Rish K. (författare)
Department of Laboratory Medicine and Pathology, Mayo Clinic Arizona, AZ, Scottsdale, United States
Palmer, Julie R. (författare)
Slone Epidemiology Center at Boston University, MA, Boston, United States
Papadimitriou, Nikos (författare)
Nutrition and Metabolism Branch, International Agency for Research on Cancer, World Health Organization, Lyon, France
Pardamean, Bens (författare)
Bioinformatics and Data Science Research Center, Bina Nusantara University, Jakarta, Indonesia
Pellatt, Andrew J. (författare)
Department of Cancer Medicine, University of Texas MD Anderson Cancer Center, TX, Houston, United States
Peoples, Anita R. (författare)
Huntsman Cancer Institute, UT, Salt Lake City, United States; Department of Population Health Sciences, University of Utah, UT, Salt Lake City, United States
Platz, Elizabeth A. (författare)
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, MD, Baltimore, United States
Rennert, Gad (författare)
Department of Community Medicine and Epidemiology, Lady Davis Carmel Medical Center, Haifa, Israel; Ruth and Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel; Clalit National Cancer Control Center, Haifa, Israel
Ruiz-Narvaez, Edward (författare)
Department of Nutritional Sciences, University of Michigan School of Public Health, MI, Ann Arbor, United States
Sakoda, Lori C. (författare)
Public Health Sciences Division, Fred Hutchinson Cancer Center, WA, Seattle, United States; Division of Research, Kaiser Permanente Northern California, CA, Oakland, United States
Scacheri, Peter C. (författare)
Department of Genetics and Genome Sciences, Case Western Reserve University, OH, Cleveland, United States
Schmit, Stephanie L. (författare)
Genomic Medicine Institute, Cleveland Clinic, OH, Cleveland, United States; Population and Cancer Prevention Program, Case Comprehensive Cancer Center, OH, Cleveland, United States
Schoen, Robert E. (författare)
Department of Medicine and Epidemiology, University of Pittsburgh Medical Center, PA, Pittsburgh, United States
Stern, Mariana C. (författare)
Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States
Su, Yu-Ru (författare)
Biostatistics Division, Kaiser Permanente Washington Health Research Institute, WA, Seattle, United States
Thomas, Duncan C. (författare)
Division of Biostatistics, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States
Tian, Yu (författare)
Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany; School of Public Health, Capital Medical University, Beijing, China
Tsilidis, Konstantinos K. (författare)
Department of Epidemiology and Biostatistics, Imperial College London, School of Public Health, London, United Kingdom; Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece
Ulrich, Cornelia M. (författare)
Huntsman Cancer Institute, UT, Salt Lake City, United States; Department of Population Health Sciences, University of Utah, UT, Salt Lake City, United States
Um, Caroline Y. (författare)
Department of Population Science, American Cancer Society, GA, Atlanta, United States
van Duijnhoven, Fränzel J B (författare)
Division of Human Nutrition and Health, Wageningen University & Research, Wageningen, Netherlands
van Guelpen, Bethany (författare)
Umeå universitet,Wallenberg centrum för molekylär medicin vid Umeå universitet (WCMM),Onkologi
White, Emily (författare)
Public Health Sciences Division, Fred Hutchinson Cancer Center, WA, Seattle, United States; Department of Epidemiology, School of Public Health, University of Washington, WA, Seattle, United States
Hsu, Li (författare)
Public Health Sciences Division, Fred Hutchinson Cancer Center, WA, Seattle, United States; Department of Biostatistics, University of Washington, WA, Seattle, United States
Moreno, Victor (författare)
Colorectal Cancer Group, ONCOBELL Program, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain; Unit of Biomarkers and Susceptibility (UBS), Oncology Data Analytics Program (ODAP), Catalan Institute of Oncology (ICO), L'Hospitalet del Llobregat, Barcelona, Spain; Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), Madrid, Spain; Department of Clinical Sciences, Faculty of Medicine and Health Sciences and Universitat de Barcelona Institute of Complex Systems (UBICS), University of Barcelona (UB), L'Hospitalet de Llobregat, Barcelona, Spain
Peters, Ulrike (författare)
Public Health Sciences Division, Fred Hutchinson Cancer Center, WA, Seattle, United States; Department of Epidemiology, School of Public Health, University of Washington, WA, Seattle, United States
Chan, Andrew T. (författare)
Clinical & Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, MA, Boston, United States; Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, MA, Boston, United States
Gauderman, W James (författare)
Division of Biostatistics, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States
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 (creator_code:org_t)
American Association for the Advancement of Science (AAAS), 2024
2024
Engelska.
Ingår i: Science Advances. - : American Association for the Advancement of Science (AAAS). - 2375-2548. ; 10:22
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • Regular, long-term aspirin use may act synergistically with genetic variants, particularly those in mechanistically relevant pathways, to confer a protective effect on colorectal cancer (CRC) risk. We leveraged pooled data from 52 clinical trial, cohort, and case-control studies that included 30,806 CRC cases and 41,861 controls of European ancestry to conduct a genome-wide interaction scan between regular aspirin/nonsteroidal anti-inflammatory drug (NSAID) use and imputed genetic variants. After adjusting for multiple comparisons, we identified statistically significant interactions between regular aspirin/NSAID use and variants in 6q24.1 (top hit rs72833769), which has evidence of influencing expression of TBC1D7 (a subunit of the TSC1-TSC2 complex, a key regulator of MTOR activity), and variants in 5p13.1 (top hit rs350047), which is associated with expression of PTGER4 (codes a cell surface receptor directly involved in the mode of action of aspirin). Genetic variants with functional impact may modulate the chemopreventive effect of regular aspirin use, and our study identifies putative previously unidentified targets for additional mechanistic interrogation.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Medical Genetics (hsv//eng)

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Av författaren/redakt...
Drew, David A.
Kim, Andre E.
Lin, Yi
Qu, Conghui
Morrison, John
Lewinger, Juan P ...
visa fler...
Kawaguchi, Eric
Wang, Jun
Fu, Yubo
Zemlianskaia, Na ...
Díez-Obrero, Vir ...
Bien, Stephanie ...
Dimou, Niki
Albanes, Demetri ...
Baurley, James W ...
Wu, Anna H.
Buchanan, Daniel ...
Potter, John D.
Prentice, Ross L ...
Harlid, Sophia, ...
Arndt, Volker
Barry, Elizabeth ...
Berndt, Sonja I.
Bouras, Emmanoui ...
Brenner, Hermann
Budiarto, Arif
Burnett-Hartman, ...
Campbell, Peter ...
Carreras-Torres, ...
Casey, Graham
Chang-Claude, Je ...
Conti, David V.
Devall, Matthew ...
Figueiredo, Jane ...
Gruber, Stephen ...
Gsur, Andrea
Gunter, Marc J.
Harrison, Tabith ...
Hidaka, Akihisa
Hoffmeister, Mic ...
Huyghe, Jeroen R ...
Jenkins, Mark A.
Jordahl, Kristin ...
Kundaje, Anshul
Le Marchand, Loi ...
Li, Li
Lynch, Brigid M.
Murphy, Neil
Nassir, Rami
Newcomb, Polly A ...
Newton, Christin ...
Obón-Santacana, ...
Ogino, Shuji
Ose, Jennifer
Pai, Rish K.
Palmer, Julie R.
Papadimitriou, N ...
Pardamean, Bens
Pellatt, Andrew ...
Peoples, Anita R ...
Platz, Elizabeth ...
Rennert, Gad
Ruiz-Narvaez, Ed ...
Sakoda, Lori C.
Scacheri, Peter ...
Schmit, Stephani ...
Schoen, Robert E ...
Stern, Mariana C ...
Su, Yu-Ru
Thomas, Duncan C ...
Tian, Yu
Tsilidis, Konsta ...
Ulrich, Cornelia ...
Um, Caroline Y.
van Duijnhoven, ...
van Guelpen, Bet ...
White, Emily
Hsu, Li
Moreno, Victor
Peters, Ulrike
Chan, Andrew T.
Gauderman, W Jam ...
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