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MRI-guided STN DBS ...
MRI-guided STN DBS in Parkinson's disease without microelectrode recording : efficacy and safety
- Artikel/kapitelEngelska2011
Förlag, utgivningsår, omfång ...
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2010-06-22
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BMJ,2011
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:umu-42438
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-42438URI
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https://doi.org/10.1136/jnnp.2010.205542DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is a commonly employed therapeutic procedure for patients with Parkinson's disease uncontrolled by medical therapies. This series describes the outcomes of 79 consecutive patients that underwent bilateral STN DBS at the National Hospital for Neurology and Neurosurgery between November 2002 and November 2008 using an MRI-guided surgical technique without microelectrode recording. Patients underwent immediate postoperative stereotactic MR imaging. The mean (SD) error in electrode placement was 1.3 (0.6) mm. There were no haemorrhagic complications. At a median follow-up period of 12 months, there was a mean improvement in the off-medication motor part of the Unified Parkinson's Disease Rating Scale (UPDRS III) of 27.7 points (SD 13.8) equivalent to a mean improvement of 52% (p<0.0001). In addition, there were significant improvements in dyskinesia duration, disability and pain, with a mean reduction in on-medication dyskinesia severity (sum of dyskinesia duration, disability and pain from UPDRS IV) from 3.15 (SD 2.33) pre-operatively, to 1.56 (SD 1.92) post-operatively (p=0.0001). Quality of life improved by a mean of 5.5 points (median 7.9 points, SD 17.3) on the Parkinson's disease Questionnaire 39 summary index. This series confirms that image-guided STN DBS without microelectrode recording can lead to substantial improvements in motor disability of well-selected PD patients with accompanying improvements in quality of life and most importantly, with very low morbidity.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Zrinzo, L
(författare)
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Martinez-Torres, I
(författare)
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Tripoliti, E
(författare)
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Petersen, E
(författare)
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Holl, E
(författare)
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Aviles-Olmos, I
(författare)
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Jahanshahi, M
(författare)
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Hariz, MarwanUmeå universitet,Neurokirurgi(Swepub:umu)hama0032
(författare)
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Limousin, P
(författare)
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Umeå universitetNeurokirurgi
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Journal of Neurology, Neurosurgery and Psychiatry: BMJ82:4, s. 358-3630022-30501468-330X
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Till lärosätets databas
- Av författaren/redakt...
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Foltynie, T
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Zrinzo, L
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Martinez-Torres, ...
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Tripoliti, E
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Petersen, E
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Holl, E
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visa fler...
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Aviles-Olmos, I
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Jahanshahi, M
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Hariz, Marwan
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Limousin, P
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Neurologi
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Journal of Neuro ...
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Umeå universitet