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EFNS guidelines on the clinical management of amyotrophic lateral sclerosis (MALS) : revised report of an EFNS task force

Andersen, Peter M. (författare)
Umeå universitet,Klinisk neurovetenskap
Abrahams, Sharon (författare)
Borasio, Gian D. (författare)
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de Carvalho, Mamede (författare)
Chio, Adriano (författare)
Van Damme, Philip (författare)
Hardiman, Orla (författare)
Kollewe, Katja (författare)
Morrison, Karen E. (författare)
Petri, Susanne (författare)
Pradat, Pierre-Francois (författare)
Silani, Vincenzo (författare)
Tomik, Barbara (författare)
Wasner, Maria (författare)
Weber, Markus (författare)
visa färre...
 (creator_code:org_t)
2012
2012
Engelska.
Ingår i: European Journal of Neurology. - 1351-5101 .- 1468-1331. ; 19:3, s. 360-E24
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • Background: The evidence base for the diagnosis and management of amyotrophic lateral sclerosis (ALS) is weak. Objectives: To provide evidence-based or expert recommendations for the diagnosis and management of ALS based on a literature search and the consensus of an expert panel. Methods: All available medical reference systems were searched, and original papers, meta-analyses, review papers, book chapters and guidelines recommendations were reviewed. The final literature search was performed in February 2011. Recommendations were reached by consensus. Recommendations: Patients with symptoms suggestive of ALS should be assessed as soon as possible by an experienced neurologist. Early diagnosis should be pursued, and investigations, including neurophysiology, performed with a high priority. The patient should be informed of the diagnosis by a consultant with a good knowledge of the patient and the disease. Following diagnosis, the patient and relatives/carers should receive regular support from a multidisciplinary care team. Medication with riluzole should be initiated as early as possible. Control of symptoms such as sialorrhoea, thick mucus, emotional lability, cramps, spasticity and pain should be attempted. Percutaneous endoscopic gastrostomy feeding improves nutrition and quality of life, and gastrostomy tubes should be placed before respiratory insufficiency develops. Non-invasive positive-pressure ventilation also improves survival and quality of life. Maintaining the patient's ability to communicate is essential. During the entire course of the disease, every effort should be made to maintain patient autonomy. Advance directives for palliative end-of-life care should be discussed early with the patient and carers, respecting the patient's social and cultural background.

Ämnesord

MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Neurosciences (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine (hsv//eng)

Nyckelord

ALS
breaking the diagnosis
bronchial secretions
caregiver
cognitive dysfunction
drooling
Evidence-based medicine
genetic counselling
nutrition
palliative care
terminal care
ventilation

Publikations- och innehållstyp

ref (ämneskategori)
art (ämneskategori)

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