B-type natriuretic peptides and their relation to cardiovascular structure and function in a population-based sample of subjects aged 70 years

Eggers, Kai M.,1962-Uppsala universitet,Institutionen för medicinska vetenskaper,UCR (författare)

The aim of the present study was to evaluate whether B-type natriuretic peptides (BNPs) could serve as screening markers for the detection of preclinical vascular disease in the community. BNP and N-terminal-pro-BNP were analyzed in 1,000 subjects aged 70 years participating in the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) study and were related to different measures of endothelial function and activation, arterial compliance, carotid atherosclerosis, and echocardiographic findings. The median levels were 42.0 ng/L for BNP and 110.7 ng/L for N-terminal-pro-BNP. On adjusted multivariate analysis, the 2 BNPs were related to increased left ventricular mass and impaired left ventricular systolic and diastolic function but not to any of the other assessed entities reflecting preclinical vascular disease. In conclusion, BNPs are strong markers of increased left ventricular mass and impaired cardiac performance but cannot be regarded as useful screening markers for the detection of preclinical states of vascular disease in elderly subjects.

Lindahl, Bertil,1957-Uppsala universitet,Institutionen för medicinska vetenskaper,UCR(Swepub:uu)belin227 (författare)
Venge, PerUppsala universitet,Klinisk kemi,Inflammation(Swepub:uu)pervenge (författare)
Lind, LarsUppsala universitet,Institutionen för medicinska vetenskaper(Swepub:uu)laeli995 (författare)
Uppsala universitetInstitutionen för medicinska vetenskaper (creator_code:org_t)

Ingår i:American Journal of Cardiology: Elsevier BV103:7, s. 1032-10380002-91491879-1913

Av författaren/redakt...: Eggers, Kai M., ...; Lindahl, Bertil, ...; Venge, Per; Lind, Lars

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