Sökning: onr:"swepub:oai:DiVA.org:uu-130093" > Enhanced neurokinin...
| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 02831nam a2200373 4500 | |
| 001 | oai:DiVA.org:uu-130093 | |
| 003 | SwePub | |
| 008 | 100831| | |||||||||||000 ||eng| | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1300932 URI |
| 040 | a (SwePub)uu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a vet2 swepub-contenttype |
| 072 | 7 | a ovr2 swepub-publicationtype |
| 100 | 1 | a Michelgård Palmquist, Åsa,d 1973-u Uppsala universitet,Psykiatri, Akademiska sjukhuset4 aut0 (Swepub:uu)asmic254 |
| 245 | 1 0 | a Enhanced neurokinin 1 receptor availability in the amygdala in posttraumatic stress disorder |
| 338 | a print2 rdacarrier | |
| 520 | a Background: Posttraumatic stress disorder (PTSD) may result from experiencing severe distress, and is in part amygdala dependent. Animal studies demonstrate that stress and negative affect enhance the amygdala-release of the neuropeptide substance P (SP) which binds to the neurokinin 1 (NK1) receptor. This positron emission tomography (PET) study investigated if NK1 receptor availability in the amygdala of PTSD patients were different from healthy control subjects. Methods: Eleven male patients with DSM-IV defined PTSD and nine healthy male control subjects were PET scanned during 60 min at rest using the NK1 preferring tracer [11C]GR205171. Parametric Patlak images were generated and analyzed using statistical parametric mapping software. The effect of age was co-varied out because the amount of NK1 receptors decline with age. Results: PTSD patients had elevated uptake of [11C]GR205171 in the amygdala as compared to controls, also when anxiety differences were controlled for. Conclusions: We suggest that enhanced NK1 receptor availability could be a risk factor for developing PTSD rather than reflecting trauma induced alterations. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Psykiatri0 (SwePub)302152 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Psychiatry0 (SwePub)302152 hsv//eng |
| 653 | a PTSD; NK1 receptor; substance P; PET; amygdala; STAI-S | |
| 653 | a Psychiatry | |
| 653 | a Psykiatri | |
| 653 | a Neuroscience | |
| 653 | a Neurovetenskap | |
| 700 | 1 | a Appel, Lieuweu Uppsala universitet,Institutionen för onkologi, radiologi och klinisk immunologi4 aut |
| 700 | 1 | a Fernandez, Manuel4 aut |
| 700 | 1 | a Furmark, Tomasu Uppsala universitet,Institutionen för psykologi4 aut |
| 700 | 1 | a von Knorring, Larsu Uppsala universitet,Psykiatri, Akademiska sjukhuset4 aut |
| 700 | 1 | a Pissiota, Anna4 aut |
| 700 | 1 | a Åhs, Fredrik4 aut |
| 700 | 1 | a Fredrikson, Matsu Uppsala universitet,Institutionen för psykologi4 aut |
| 710 | 2 | a Uppsala universitetb Psykiatri, Akademiska sjukhuset4 org |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-130093 |
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