onr:"swepub:oai:DiVA.org:uu-165390"
Sökning: onr:"swepub:oai:DiVA.org:uu-165390" > P2Y12 platelet inhi...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 02762naa a2200325 4500 | |
| 001 | oai:DiVA.org:uu-165390 | |
| 003 | SwePub | |
| 008 | 120105s2012 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1653902 URI |
| 024 | 7 | a https://doi.org/10.1007/s11239-011-0667-52 DOI |
| 040 | a (SwePub)uu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Damman, Peteru Uppsala universitet,Uppsala kliniska forskningscentrum (UCR)4 aut |
| 245 | 1 0 | a P2Y12 platelet inhibition in clinical practice |
| 264 | c 2011-12-20 | |
| 264 | 1 | b Springer Science and Business Media LLC,c 2012 |
| 338 | a print2 rdacarrier | |
| 520 | a Platelet adhesion, activation and aggregation play a pivotal role in atherothrombosis. Intracoronary atherothrombosis is the most common cause of the development of acute coronary syndrome (ACS), and plays a central role in complications occurring around percutaneous coronary intervention (PCI) including recurrent ACS, procedure-related myocardial infarction or stent thrombosis. Inhibition of platelet aggregation by medical treatment impairs formation and progression of thrombotic processes and is therefore of great importance in the prevention of complications after an ACS or around PCI. An essential part in the platelet activation process is the interaction of adenosine diphosphate (ADP) with the platelet P2Y12 receptor. The P2Y12 receptor is the predominant receptor involved in the ADP-stimulated activation of the glycoprotein IIb/IIIa receptor. Activation of the glycoprotein IIb/IIIa receptor results in enhanced platelet degranulation and thromboxane production, and prolonged platelet aggregation. The objectives of this review are to discuss the pharmacological limitations of the P2Y12 inhibitor clopidogrel, and describe the novel alternative P2Y12 inhibitors prasugrel and ticagrelor and the clinical implications of the introduction of these new medicines. | |
| 700 | 1 | a Woudstra, Pier4 aut |
| 700 | 1 | a Kuijt, Wichert J4 aut |
| 700 | 1 | a de Winter, Robbert J4 aut |
| 700 | 1 | a James, Stefan K,d 1964-u Uppsala universitet,Institutionen för medicinska vetenskaper,Uppsala kliniska forskningscentrum (UCR),Kardiologi4 aut0 (Swepub:uu)stjam367 |
| 710 | 2 | a Uppsala universitetb Uppsala kliniska forskningscentrum (UCR)4 org |
| 773 | 0 | t Journal of Thrombosis and Thrombolysisd : Springer Science and Business Media LLCg 33:2, s. 143-153q 33:2<143-153x 0929-5305x 1573-742X |
| 856 | 4 | u https://link.springer.com/content/pdf/10.1007%2Fs11239-011-0667-5.pdf |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-165390 |
| 856 | 4 8 | u https://doi.org/10.1007/s11239-011-0667-5 |
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