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Pre-hospital thromb...
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Björklund, ErikUppsala universitet,Institutionen för medicinska vetenskaper,UCR
(författare)
Pre-hospital thrombolysis delivered by paramedics is associated with reduced time delay and mortality in ambulance-transported real-life patients with ST-elevation myocardial infarction
- Artikel/kapitelEngelska2006
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2006-04-19
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Oxford University Press (OUP),2006
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LIBRIS-ID:oai:DiVA.org:uu-23965
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-23965URI
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https://doi.org/10.1093/eurheartj/ehi886DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:1947510URI
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-37648URI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
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AIMS: There are sparse data on the impact of pre-hospital thrombolysis (PHT) in real-life patients. We therefore evaluated treatment delays and outcome in a large cohort of ambulance-transported real-life patients with ST-elevation myocardial infarction (STEMI) according to PHT delivered by paramedics or in-hospital thrombolysis. METHODS AND RESULTS: Prospective cohort study used data from the Swedish Register of Cardiac intensive care on patients admitted to the coronary care units of 75 Swedish hospitals in 2001-2004. Ambulance-transported thrombolytic-treated patients younger than age 80 with a diagnosis of acute myocardial infarction were included. Patients with PHT (n=1690) were younger, had a lower prevalence of co-morbid conditions, fewer complications, and a higher ejection fraction (EF) than in-hospital-treated patients (n=3685). Median time from symptom onset to treatment was 113 min for PHT and 165 min for in-hospital thrombolysis. One-year mortality was 7.2 vs. 11.8% for PHT and in-hospital thrombolysis, respectively. In a multivariable analysis, after adjusting for baseline characteristics and rescue angioplasty, PHT was associated with lower 1-year mortality (odds ratio 0.71, 0.55-0.92, P=0.008). CONCLUSION: When compared with regular in-hospital thrombolysis, pre-hospital diagnosis and thrombolysis with trained paramedics in the ambulances are associated with reduced time to thrombolysis by almost 1 h and reduced adjusted 1-year mortality by 30% in real-life STEMI patients.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Stenestrand, Ulf,1961-Östergötlands Läns Landsting,Linköpings universitet,Hälsouniversitetet,Kardiologi,Kardiologiska kliniken(Swepub:liu)ulfst38
(författare)
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Lindbäck, JohanUppsala universitet,Institutionen för medicinska vetenskaper,UCR(Swepub:uu)jolin255
(författare)
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Svensson, LeifKarolinska Institutet
(författare)
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Wallentin, Lars,1943-Uppsala universitet,Institutionen för medicinska vetenskaper,UCR(Swepub:uu)larswall
(författare)
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Lindahl, Bertil,1957-Uppsala universitet,Institutionen för medicinska vetenskaper,UCR(Swepub:uu)belin227
(författare)
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Uppsala universitetInstitutionen för medicinska vetenskaper
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:European Heart Journal: Oxford University Press (OUP)27:10, s. 1146-11520195-668X1522-9645
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