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Sökning: onr:"swepub:oai:DiVA.org:uu-307756" > Design and rational...

Design and rationale for a randomised comparison of everolimus-eluting stents and coronary artery bypass graft surgery in selected patients with left main coronary artery disease : the EXCEL trial

Kappetein, Arie Pieter (författare)
Erasmus MC, Dept Cardiothorac Surg, Rotterdam, Netherlands.
Serruys, Patrick W. (författare)
Imperial Coll London, NHLI, Int Ctr Circulatory Hlth, London, England.
Sabik, Joseph F. (författare)
Cleveland Clin Fdn, Dept Thorac & Cardiovasc Surg, 9500 Euclid Ave, Cleveland, OH 44195 USA.
visa fler...
Leon, Martin B. (författare)
Columbia Univ, Dept Med, Med Ctr, New York, NY USA.;Cardiovasc Res Fdn, New York, NY USA.
Taggart, David P. (författare)
John Radcliffe Hosp, Dept Cardiac Surg, Oxford, England.
Morice, Marie-Claude (författare)
Inst Hosp Jacques Cartier, Dept Cardiol, Massy, France.
Gersh, Bernard J. (författare)
Mayo Clin, Coll Med, Dept Cardiovasc Dis, Rochester, MN USA.
Pocock, Stuart J. (författare)
London Sch Hyg & Trop Med, Dept Med Stat, London, England.
Cohen, David J. (författare)
St Lukes Mid Amer Heart Inst, Kansas City, MO USA.
Wallentin, Lars (författare)
Uppsala universitet,Kardiologi,Uppsala kliniska forskningscentrum (UCR)
Ben-Yehuda, Ori (författare)
Columbia Univ, Dept Med, Med Ctr, New York, NY USA.;Cardiovasc Res Fdn, New York, NY USA.
van Es, Gerrit-Anne (författare)
Cardialysis, Rotterdam, Netherlands.
Simonton, Charles A. (författare)
Abbott Vasc, Santa Clara, CA USA.
Stone, Gregg W. (författare)
Columbia Univ, Dept Med, Med Ctr, New York, NY USA.;Cardiovasc Res Fdn, New York, NY USA.
visa färre...
Erasmus MC, Dept Cardiothorac Surg, Rotterdam, Netherlands Imperial Coll London, NHLI, Int Ctr Circulatory Hlth, London, England. (creator_code:org_t)
2016
2016
Engelska.
Ingår i: EuroIntervention. - 1774-024X .- 1969-6213. ; 12:7, s. 861-872
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • Aims: Coronary artery bypass graft (CABG) surgery is the standard of care for revascularisation of patients with left main coronary artery disease (LMCAD). Recent studies have suggested that percutaneous coronary intervention (PCI) with drug-eluting stents (DES) may provide comparable outcomes in selected patients with LMCAD without extensive CAD. We therefore designed a trial to investigate whether PCI with XIENCE cobalt-chromium everolimus-eluting stents (CoCr-EES) would result in non-inferior or superior clinical outcomes to CABG in selected patients with LMCAD. Methods and results: The Evaluation of XIENCE versus Coronary Artery Bypass Surgery for Effectiveness of Left Main Revascularization (EXCEL) trial is a prospective, open-label, multicentre, international study of 1,900 randomised subjects. Patients with significant LMCAD with a SYNTAX score <= 32 and local Heart Team consensus that the subject is appropriate for revascularisation by both PCI and CABG are consented and randomised 1:1 to undergo PCI using CoCr-EES or CABG. All patients undergo follow-up for five years. The primary endpoint is the three-year composite rate of death, stroke or myocardial infarction, assessed at a median follow-up of at least three years (with at least two-year follow-up in all patients), powered for sequential non-inferiority and superiority testing. Conclusions: The EXCEL study will define the contemporary roles of CABG and PCI using XIENCE CoCr-EES in patients with LMCAD disease with low and intermediate SYNTAX scores.

Ämnesord

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Kardiologi (hsv//swe)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine (hsv//eng)

Nyckelord

coronary bypass surgery
drug -eluting stents
left main disease
randomised trial

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