Escala-Garcia, MariaAntoni van Leeuwenhoek Hosp, Netherlands Canc Inst, Divi Mol Pathol, Amsterdam, Netherlands,Netherlands Cancer Institute
(författare)
A network analysis to identify mediators of germline-driven differences in breast cancer prognosis
Identifying the underlying genetic drivers of the heritability of breast cancer prognosis remains elusive. We adapt a network-based approach to handle underpowered complex datasets to provide new insights into the potential function of germline variants in breast cancer prognosis. This network-based analysis studies similar to 7.3 million variants in 84,457 breast cancer patients in relation to breast cancer survival and confirms the results on 12,381 independent patients. Aggregating the prognostic effects of genetic variants across multiple genes, we identify four gene modules associated with survival in estrogen receptor (ER)-negative and one in ER-positive disease. The modules show biological enrichment for cancer-related processes such as G-alpha signaling, circadian clock, angiogenesis, and Rho-GTPases in apoptosis.
Abraham, JeanUniv Cambridge, Dept Oncol, Ctr Canc Genet Epidemiol, Cambridge, England;Cambridge Expt Canc Med Ctr, Cambridge, England;Univ Cambridge NHS Fdn Hosp, NIHR Cambridge Biomed Res Ctr, Cambridge, England;Univ Cambridge NHS Fdn Hosp, Cambridge Breast Unit, Cambridge, England
(författare)
Andrulis, Irene L.Lunenfeld Tanenbaum Res Inst Mt Sinai Hosp, Fred A Litwin Ctr Canc Genet, Toronto, ON, Canada;Univ Toronto, Dept Mol Genet, Toronto, ON, Canada
(författare)
Anton-Culver, HodaUniv Calif Irvine, Genet Epidemiol Res Inst, Dept Epidemiol, Irvine, CA USA
(författare)
Arndt, VolkerGerman Canc Res Ctr, Div Clin Epidemiol & Aging Res, Heidelberg, Germany
(författare)
Ashworth, AlanUniv Calif San Francisco, UCSF Helen Diller Family Comprehens Canc Ctr, San Francisco, CA USA,Univ Warwick, Warwick Clin Trials Unit, Coventry, W Midlands, England,Harvard Med Sch, Brigham & Womens Hosp, Dept Med, Channing Div Network Med, Boston, MA USA;Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA,Friedrich Alexander Univ Erlangen Nuremberg, Univ Hosp Erlangen, Comprehens Canc Ctr ER EMN, Dept Gynecol & Obstet, Erlangen, Germany;Univ Calif Los Angeles, David Geffen Sch Med, Dept Med, Div Hematol & Oncol, Los Angeles, CA USA,Hosp Clino San Carlos, Inst Invest Sanitaria San Carlos IdISSC, Ctr Invest Biomed Red Canc CIBERONC, Madrid, Spain,Univ Southern Calif, Keck Sch Med, Dept Prevent Med, Los Angeles, CA USA,Univ Cambridge, Dept Oncol, Ctr Canc Genet Epidemiol, Cambridge, England,Leiden Univ Med Ctr, Dept Surg, Leiden, Netherlands,Univ N Carolina, Lineberger Comprehens Canc Ctr, Dept Epidemiol, Chapel Hill, NC USA,Antoni van Leeuwenhoek Hosp, Netherlands Canc Inst, Div Mol Carcinogenesis, Amsterdam, Netherlands;Delft Univ Technol, Fac EEMCS, Delft, Netherlands
(författare)
Auer, Paul L.Fred Hutchinson Canc Res Ctr, Canc Prevent Program, Seattle, WA USA;Univ Wisconsin Milwaukee, Zilber Sch Publ Hlth, Milwaukee, WI USA
(författare)
Bogdanova, Natalia V.Hannover Med Sch, Dept Radiat Oncol, Hannover, Germany;Hannover Med Sch, Gynaecol Res Unit, Hannover, Germany;NN Alexandrov Res Inst Oncol & Med Radiol, Minsk, BELARUS
(författare)
Brenner, HermannGerman Canc Res Ctr, Div Clin Epidemiol & Aging Res, Heidelberg, Germany;German Canc Consortium DKTK, German Canc Res Ctr DKFZ, Heidelberg, Germany;Natl Ctr Tumor Dis NCT, Heidelberg, Germany;German Canc Res Ctr, Div Prevent Oncol, Heidelberg, Germany,German Cancer Research Centre
(författare)
Dwek, MiriamUniv Westminster, Fac Sci & Technol, Dept Biomed Sci, London, England
(författare)
Earl, Helena M.Univ Cambridge NHS Fdn Hosp, NIHR Cambridge Biomed Res Ctr, Cambridge, England;Univ Cambridge NHS Fdn Hosp, Cambridge Breast Unit, Cambridge, England;Univ Cambridge, Dept Oncol, Cambridge, England
(författare)
Eccles, Diana M.Univ Southampton, Fac Med, Canc Sci Acad Unit, Southampton, Hants, England
(författare)
Eliassen, A. HeatherHarvard Med Sch, Brigham & Womens Hosp, Dept Med, Channing Div Network Med, Boston, MA USA;Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA
(författare)
Ellberg, CarolinaLund Univ, Dept Canc Epidemiol Clin Sci, Lund, Sweden,LUCC: Lund University Cancer Centre,Tumor microenvironment,LUCC: Lunds universitets cancercentrum,Tumörmikromiljö
(författare)
Evans, D. GarethUniv Manchester, Manchester Acad Hlth Sci Ctr, Fac Biol Med & Hlth, Sch Biol Sci,Div Evolut & Genom Med, Manchester, Lancs, England;Manchester Univ Hosp NHS Fdn Trust, Manchester Acad Hlth Sci Ctr, Manchester Ctr Genom Med, St Marys Hosp,Genom Med, Manchester, Lancs, England;Manchester Univ NHS Fdn Trust, Manchester Acad Hlth Sci Ctr, NIHR Manchester Biomed Res Ctr, Manchester, Lancs, England
(författare)
Fasching, Peter A.Friedrich Alexander Univ Erlangen Nuremberg, Univ Hosp Erlangen, Comprehens Canc Ctr ER EMN, Dept Gynecol & Obstet, Erlangen, Germany;Univ Calif Los Angeles, David Geffen Sch Med, Dept Med, Div Hematol & Oncol, Los Angeles, CA USA
(författare)
Figueroa, JonineNatl Canc Inst, Natl Inst Hlth, Dept Hlth & Human Serv, Div Canc Epidemiol & Genet, Bethesda, MD USA;Univ Edinburgh Med Sch, Usher Inst Populat Hlth Sci & Informat, Edinburgh, Midlothian, Scotland;Canc Res UK Edinburgh Ctr, Edinburgh, Midlothian, Scotland
(författare)
Gago-Dominguez, ManuelaComplejo Hospitalario Univ Santiago, SERGAS, Inst Invest Sanitaria Santiago Compostela IDIS, Galician Fdn Genom Med,Genom Med Grp, Santiago De Compostela, Spain;Univ Calif San Diego, Moores Canc Ctr, La Jolla, CA USA
(författare)
Gapstur, Susan M.Amer Canc Soc, Epidemiol Res Program, Atlanta, GA USA
(författare)
Garcia-Closas, MontserratNatl Canc Inst, Natl Inst Hlth, Dept Hlth & Human Serv, Div Canc Epidemiol & Genet, Bethesda, MD USA;Inst Canc Res, Div Genet & Epidemiol, London, England
(författare)
Garcia-Saenz, Jose A.Hosp Clino San Carlos, Inst Invest Sanitaria San Carlos IdISSC, Ctr Invest Biomed Red Canc CIBERONC, Madrid, Spain
(författare)
Gaudet, Mia M.Amer Canc Soc, Epidemiol Res Program, Atlanta, GA USA
(författare)
George, AngelaInst Canc Res, Div Genet & Epidemiol, London, England
(författare)
Giles, Graham G.Canc Council Victoria, Canc Epidemiol Div, Melbourne, Vic, Australia;Univ Melbourne, Melbourne Sch Populat & Global Hlth, Ctr Epidemiol & Biostat, Melbourne, Vic, Australia;Monash Univ, Dept Epidemiol & Prevent Med, Melbourne, Vic, Australia,Univ Manchester, Manchester Acad Hlth Sci Ctr, Fac Biol Med & Hlth, Sch Biol Sci,Div Evolut & Genom Med, Manchester, Lancs, England;Manchester Univ Hosp NHS Fdn Trust, Manchester Acad Hlth Sci Ctr, Manchester Ctr Genom Med, St Marys Hosp,Genom Med, Manchester, Lancs, England
(författare)
Goldgar, David E.Univ Utah Sch Med Salt, Huntsman Canc Inst, Dept Dermatol, Salt Lake City, UT USA
(författare)
Gonzalez-Neira, AnnaSpanish Natl Canc Res Ctr CNIO, Human Canc Genet Programme, Madrid, Spain
(författare)
Manoochehri, MehdiGerman Canc Res Ctr, Mol Genet Breast Canc, Heidelberg, Germany,Harvard Med Sch, Brigham & Womens Hosp, Dept Med, Channing Div Network Med, Boston, MA USA;Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA;Harvard TH Chan Sch Publ Hlth, Program Genet Epidemiol & Stat Genet, Boston, MA USA
(författare)
Manoukian, SiranoushFdn IRCCS Ist Nazl Tumori Milano INT, Dept Med Oncol & Hematol, Unit Med Genet, Milan, Italy
(författare)
Margolin, SaraSsdersjukhuset, Dept Oncol, Stockholm, Sweden;Karolinska Inst, Ssdersjukhuset, Dept Clin Sci & Educ, Stockholm, Sweden
(författare)
Martinez, Maria ElenaUniv Calif San Diego, Moores Canc Ctr, La Jolla, CA USA;Univ Calif San Diego, Dept Family Med & Publ Hlth, La Jolla, CA USA
(författare)
Milne, Roger L.Canc Council Victoria, Canc Epidemiol Div, Melbourne, Vic, Australia;Univ Melbourne, Melbourne Sch Populat & Global Hlth, Ctr Epidemiol & Biostat, Melbourne, Vic, Australia;Monash Univ, Sch Clin Sci Monash Hlth, Precis Med, Clayton, Vic, Australia
(författare)
Mulligan, Anna MarieUniv Toronto, Dept Lab Med & Pathobiol, Toronto, ON, Canada;Univ Hlth Network, Lab Med Program, Toronto, ON, Canada
(författare)
Neuhausen, Susan L.Beckman Res Inst City Hope, Dept Populat Sci, Duarte, CA USA
(författare)
Nevanlinna, HeliUniv Helsinki, Helsinki Univ Hosp, Dept Obstet & Gynecol, Helsinki, Finland
(författare)
Newman, William G.Univ Manchester, Manchester Acad Hlth Sci Ctr, Fac Biol Med & Hlth, Sch Biol Sci,Div Evolut & Genom Med, Manchester, Lancs, England;Manchester Univ Hosp NHS Fdn Trust, Manchester Acad Hlth Sci Ctr, Manchester Ctr Genom Med, St Marys Hosp,Genom Med, Manchester, Lancs, England
(författare)
Olshan, Andrew F.Univ N Carolina, Lineberger Comprehens Canc Ctr, Dept Epidemiol, Chapel Hill, NC USA
(författare)
Olson, Janet E.
(författare)
Olsson, HakanLund Univ, Dept Canc Epidemiol Clin Sci, Lund, Sweden,LUCC: Lund University Cancer Centre,EpiHealth: Epidemiology for Health,Medical oncology,LUCC: Lunds universitets cancercentrum,Medicinsk onkologi
(författare)
Orr, NickQueens Univ Belfast, Ctr Canc Res & Cell Biol, Belfast, Antrim, North Ireland
(författare)
Swerdlow, Anthony J.Inst Canc Res, Div Genet & Epidemiol, London, England;Inst Canc Res, Div Breast Canc Res, London, England
(författare)
Tamimi, Rulla M.Harvard Med Sch, Brigham & Womens Hosp, Dept Med, Channing Div Network Med, Boston, MA USA;Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA;Harvard TH Chan Sch Publ Hlth, Program Genet Epidemiol & Stat Genet, Boston, MA USA
(författare)
Tapper, William J.Univ Southampton, Fac Med, Southampton, Hants, England
(författare)
Teixeira, Manuel R.Portuguese Oncol Inst, Dept Genet, Porto, Portugal;Univ Porto, Biomed Sci Inst ICBAS, Porto, Portugal
(författare)
Terry, Mary BethColumbia Univ, Mailman Sch Publ Hlth, Dept Epidemiol, New York, NY USA
(författare)
Thorne, HeatherPeter MacCallum Canc Ctr, Melbourne, Vic, Australia;Univ Melbourne, Sir Peter MacCallum Dept Oncol, Melbourne, Vic, Australia
(författare)
Tollenaar, Rob A. E. M.Leiden Univ Med Ctr, Dept Surg, Leiden, Netherlands
(författare)
Tomlinson, IanUniv Birmingham, Inst Canc & Genom Sci, Birmingham, W Midlands, England;Univ Oxford, Oxford NIHR Biomed Res Ctr, Oxford, England;Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford, England
(författare)
Troester, Melissa A.Univ N Carolina, Lineberger Comprehens Canc Ctr, Dept Epidemiol, Chapel Hill, NC USA
(författare)
Truong, ThereseUniv Paris Sud, INSERM, Univ Paris Saclay, Ctr Res Epidemiol & Populat Hlth CESP,Canc & Envi, Villejuif, France
(författare)
Turnbull, ClareInst Canc Res, Div Genet & Epidemiol, London, England
(författare)
Vachon, Celine M.
(författare)
van der Kolk, Lizet E.Antoni van Leeuwenhoek Hosp, Netherlands Canc Inst, Family Canc Clin, Amsterdam, Netherlands
(författare)
Wang, QinUniv Cambridge, Ctr Canc Genet Epidemiol, Dept Publ Hlth & Primary Care, Cambridge, England
(författare)
Winqvist, RobertUniv Oulu, Lab Canc Genet & Tumor Biol, Canc & Translat Med Res Unit, Bioctr Oulu, Oulu, Finland;Northern Finland Lab Ctr Oulu, Lab Canc Genet & Tumor Biol, Oulu, Finland
(författare)
Wolk, AlicjaUppsala universitet,Ortopedi,Karolinska Inst, Inst Environm Med, Stockholm, Sweden(Swepub:uu)alwol516
(författare)
Yang, Xiaohong R.Natl Canc Inst, Natl Inst Hlth, Dept Hlth & Human Serv, Div Canc Epidemiol & Genet, Bethesda, MD USA
(författare)
Ziogas, ArgyriosUniv Calif Irvine, Genet Epidemiol Res Inst, Dept Epidemiol, Irvine, CA USA
(författare)
Pharoah, Paul D. P.Univ Cambridge, Dept Oncol, Ctr Canc Genet Epidemiol, Cambridge, England;Univ Cambridge, Ctr Canc Genet Epidemiol, Dept Publ Hlth & Primary Care, Cambridge, England
(författare)
Hall, PerKarolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden;Ssdersjukhuset, Dept Oncol, Stockholm, Sweden,Karolinska Institute,Karolinska Institutet
(författare)
Wessels, Lodewyk F. A.Antoni van Leeuwenhoek Hosp, Netherlands Canc Inst, Div Mol Carcinogenesis, Amsterdam, Netherlands;Delft Univ Technol, Fac EEMCS, Delft, Netherlands
(författare)
Chenevix-Trench, GeorgiaQIMR Berghofer Med Res Inst, Dept Genet & Computat Biol, Brisbane, Qld, Australia
(författare)
Bader, Gary D.Univ Toronto, Dept Mol Genet, Toronto, ON, Canada;Univ Toronto, Donnelly Ctr, Toronto, ON, Canada
(författare)
Doerk, ThiloHannover Med Sch, Gynaecol Res Unit, Hannover, Germany
(författare)
Easton, Douglas F.Univ Cambridge, Dept Oncol, Ctr Canc Genet Epidemiol, Cambridge, England;Univ Cambridge, Ctr Canc Genet Epidemiol, Dept Publ Hlth & Primary Care, Cambridge, England
(författare)
Canisius, SanderAntoni van Leeuwenhoek Hosp, Netherlands Canc Inst, Divi Mol Pathol, Amsterdam, Netherlands;Antoni van Leeuwenhoek Hosp, Netherlands Canc Inst, Div Mol Carcinogenesis, Amsterdam, Netherlands,Netherlands Cancer Institute
(författare)
Schmidt, Marjanka K.Antoni van Leeuwenhoek Hosp, Netherlands Canc Inst, Divi Mol Pathol, Amsterdam, Netherlands;Antoni van Leeuwenhoek Hosp, Netherlands Canc Inst, Div Psychosocial Res & Epidemiol, Amsterdam, Netherlands,Netherlands Cancer Institute
(författare)
Antoni van Leeuwenhoek Hosp, Netherlands Canc Inst, Divi Mol Pathol, Amsterdam, NetherlandsNetherlands Cancer Institute
(creator_code:org_t)
Sammanhörande titlar
Ingår i:Nature Communications: NATURE PUBLISHING GROUP11:12041-1723