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Sökning: onr:"swepub:oai:DiVA.org:uu-427573" > Mendelian Randomiza...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00005572naa a2200973 4500
001oai:DiVA.org:uu-427573
003SwePub
008201209s2020 | |||||||||||000 ||eng|
009oai:swepub.ki.se:473518
024a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4275732 URI
024a https://doi.org/10.1158/1055-9965.EPI-19-08912 DOI
024a http://kipublications.ki.se/Default.aspx?queryparsed=id:1439248352 URI
040 a (SwePub)uud (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
100a Khankari, Nikhil K4 aut
2451 0a Mendelian Randomization of Circulating Polyunsaturated Fatty Acids and Colorectal Cancer Risk.
264 1c 2020
338 a print2 rdacarrier
520 a BACKGROUND: Results from epidemiologic studies examining polyunsaturated fatty acids (PUFA) and colorectal cancer risk are inconsistent. Mendelian randomization may strengthen causal inference from observational studies. Given their shared metabolic pathway, examining the combined effects of aspirin/NSAID use with PUFAs could help elucidate an association between PUFAs and colorectal cancer risk.METHODS: Information was leveraged from genome-wide association studies (GWAS) regarding PUFA-associated SNPs to create weighted genetic scores (wGS) representing genetically predicted circulating blood PUFAs for 11,016 non-Hispanic white colorectal cancer cases and 13,732 controls in the Genetics and Epidemiology of Colorectal Cancer Consortium (GECCO). Associations per SD increase in the wGS were estimated using unconditional logistic regression. Interactions between PUFA wGSs and aspirin/NSAID use on colorectal cancer risk were also examined.RESULTS: Modest colorectal cancer risk reductions were observed per SD increase in circulating linoleic acid [ORLA = 0.96; 95% confidence interval (CI) = 0.93-0.98; P = 5.2 × 10-4] and α-linolenic acid (ORALA = 0.95; 95% CI = 0.92-0.97; P = 5.4 × 10-5), whereas modest increased risks were observed for arachidonic (ORAA = 1.06; 95% CI = 1.03-1.08; P = 3.3 × 10-5), eicosapentaenoic (OREPA = 1.04; 95% CI = 1.01-1.07; P = 2.5 × 10-3), and docosapentaenoic acids (ORDPA = 1.03; 95% CI = 1.01-1.06; P = 1.2 × 10-2). Each of these effects was stronger among aspirin/NSAID nonusers in the stratified analyses.CONCLUSIONS: Our study suggests that higher circulating shorter-chain PUFAs (i.e., LA and ALA) were associated with reduced colorectal cancer risk, whereas longer-chain PUFAs (i.e., AA, EPA, and DPA) were associated with an increased colorectal cancer risk.IMPACT: The interaction of PUFAs with aspirin/NSAID use indicates a shared colorectal cancer inflammatory pathway. Future research should continue to improve PUFA genetic instruments to elucidate the independent effects of PUFAs on colorectal cancer.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
700a Banbury, Barbara L4 aut
700a Borges, Maria C4 aut
700a Haycock, Philip4 aut
700a Albanes, Demetrius4 aut
700a Arndt, Volker4 aut
700a Berndt, Sonja I4 aut
700a Bézieau, Stéphane4 aut
700a Brenner, Hermann4 aut
700a Campbell, Peter T4 aut
700a Casey, Graham4 aut
700a Chan, Andrew T4 aut
700a Chang-Claude, Jenny4 aut
700a Conti, David V4 aut
700a Cotterchio, Michelle4 aut
700a English, Dallas R4 aut
700a Figueiredo, Jane C4 aut
700a Giles, Graham G4 aut
700a Giovannucci, Edward L4 aut
700a Gunter, Marc J4 aut
700a Hampe, Jochen4 aut
700a Hoffmeister, Michael4 aut
700a Hopper, John L4 aut
700a Jenkins, Mark A4 aut
700a Joshi, Amit D4 aut
700a Marchand, Loic Le4 aut
700a Lemire, Mathieu4 aut
700a Li, Christopher I4 aut
700a Li, Li4 aut
700a Lindblom, Annika4 aut
700a Martín, Vicente4 aut
700a Moreno, Victor4 aut
700a Newcomb, Polly A4 aut
700a Offit, Kenneth4 aut
700a Pharoah, Paul D P4 aut
700a Rennert, Gad4 aut
700a Sakoda, Lori C4 aut
700a Schafmayer, Clemens4 aut
700a Schmit, Stephanie L4 aut
700a Slattery, Martha L4 aut
700a Song, Mingyang4 aut
700a Thibodeau, Stephen N4 aut
700a Ulrich, Cornelia M4 aut
700a Weinstein, Stephanie J4 aut
700a White, Emily4 aut
700a Win, Aung Ko4 aut
700a Wolk, Alicjau Uppsala universitet,Ortopedi4 aut0 (Swepub:uu)alwol516
700a Woods, Michael O4 aut
700a Wu, Anna H4 aut
700a Cai, Qiuyin4 aut
700a Denny, Joshua C4 aut
700a Edwards, Todd L4 aut
700a Murff, Harvey J4 aut
700a Gruber, Stephen B4 aut
700a Peters, Ulrike4 aut
700a Zheng, Wei4 aut
710a Uppsala universitetb Ortopedi4 org
773t Cancer Epidemiology, Biomarkers and Preventiong 29:4, s. 860-870q 29:4<860-870x 1055-9965x 1538-7755
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-427573
8564 8u https://doi.org/10.1158/1055-9965.EPI-19-0891
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:143924835

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