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Sökning: onr:"swepub:oai:DiVA.org:uu-438340" > Subcortical surface...

Subcortical surface morphometry in substance dependence : An ENIGMA addiction working group study

Chye, Yann (författare)
Monash Univ, Turner Inst Brain & Mental Hlth, Sch Psychol Sci, Clayton, Vic, Australia.
Mackey, Scott (författare)
Univ Vermont, Dept Psychiat, Burlington, VT 05405 USA.
Gutman, Boris A. (författare)
IIT, Biomed Engn, Chicago, IL 60616 USA.
visa fler...
Ching, Christopher R. K. (författare)
Univ Southern Calif, Mark & Mary Stevens Neuroimaging & Informat Inst, Imaging Genet Ctr, Dept Neurol,Keck Sch Med, Los Angeles, CA USA.
Batalla, Albert (författare)
Univ Utrecht, Dept Psychiat, Univ Med Ctr Utrecht, Brain Ctr, Utrecht, Netherlands.;Univ Barcelona, Dept Psychiat & Psychol, Hosp Clin, IDIBAPS,CIBERSAM,Inst Neurosci, Barcelona, Spain.
Blaine, Sara (författare)
Yale Univ, Sch Med, Dept Psychiat, New Haven, CT 06520 USA.;Yale Univ, Sch Med, Dept Neurosci, New Haven, CT 06520 USA.
Brooks, Samantha (författare)
Uppsala universitet,Schiöth: Funktionell farmakologi,Liverpool John Moores Univ, Sch Psychol, Fac Hlth, Liverpool L3 3AF, Merseyside, England.
Caparelli, Elisabeth C. (författare)
NIDA, Neuroimaging Res Branch, Intramural Res Program, Baltimore, MD USA.
Cousijn, Janna (författare)
Univ Amsterdam, Dept Dev Psychol, Amsterdam, Netherlands.
Dagher, Alain (författare)
McGill Univ, McConnell Brain Imaging Ctr, Montreal Neurol Inst, Montreal, PQ, Canada.
Foxe, John J. (författare)
Univ Rochester, Sch Med & Dent, Dept Neurosci, Rochester, NY USA.;Univ Rochester, Sch Med & Dent, Ernest J Del Monte Inst Neurosci, Rochester, NY USA.
Goudriaan, Anna E. (författare)
Univ Amsterdam, Amsterdam UMC, Dept Psychiat, Amsterdam Inst Addict Res, Amsterdam, Netherlands.;Arkin Mental Hlth Care, Dept Res & Qual Care, Amsterdam, Netherlands.
Hester, Robert (författare)
Univ Melbourne, Melbourne Sch Psychol Sci, Melbourne, Vic, Australia.
Hutchison, Kent (författare)
Univ Colorado, Dept Psychol & Neurosci, Boulder, CO 80309 USA.
Jahanshad, Neda (författare)
Univ Southern Calif, Mark & Mary Stevens Neuroimaging & Informat Inst, Imaging Genet Ctr, Dept Neurol,Keck Sch Med, Los Angeles, CA USA.
Kaag, Anne M. (författare)
Univ Amsterdam, Dept Dev Psychol, Amsterdam, Netherlands.
Korucuoglu, Ozlem (författare)
Washington Univ, Sch Med, Dept Psychiat, St Louis, MO 63110 USA.
Li, Chiang-Shan R. (författare)
Yale Univ, Sch Med, Dept Psychiat, New Haven, CT 06520 USA.;Yale Univ, Sch Med, Dept Neurosci, New Haven, CT 06520 USA.
London, Edythe D. (författare)
Univ Calif Los Angeles, David Geffen Sch Med, Jane & Terry Semel Inst Neurosci & Human Behav, Los Angeles, CA 90095 USA.
Lorenzetti, Valentina (författare)
Monash Univ, Turner Inst Brain & Mental Hlth, Sch Psychol Sci, Clayton, Vic, Australia.;Australian Catholic Univ, Sch Psychol, Fac Hlth Sci, Melbourne, Vic, Australia.
Luijten, Maartje (författare)
Radboud Univ Nijmegen, Inst Behav Sci, Nijmegen, Netherlands.
Martin-Santos, Rocio (författare)
Univ Barcelona, Dept Psychiat & Psychol, Hosp Clin, IDIBAPS,CIBERSAM,Inst Neurosci, Barcelona, Spain.
Meda, Shashwath A. (författare)
Hartford Hosp IOL, Olin Neuropsychiat Res Ctr, Hartford, CT USA.
Momenan, Reza (författare)
NIAAA, Clin NeuroImaging Res Core, Div Intramural Clin & Biol Res, Bethesda, MD USA.
Morales, Angelica (författare)
Univ Calif Los Angeles, David Geffen Sch Med, Jane & Terry Semel Inst Neurosci & Human Behav, Los Angeles, CA 90095 USA.
Orr, Catherine (författare)
Univ Vermont, Dept Psychiat, Burlington, VT 05405 USA.
Paulus, Martin P. (författare)
VA San Diego Healthcare Syst, San Diego, CA USA.;Univ Calif San Diego, Dept Psychiat, La Jolla, CA 92093 USA.;Laureate Inst Brain Res, Tulsa, OK USA.
Pearlson, Godfrey (författare)
Yale Univ, Sch Med, Dept Psychiat, New Haven, CT 06520 USA.;Yale Univ, Sch Med, Dept Neurosci, New Haven, CT 06520 USA.
Reneman, Liesbeth (författare)
Locat AMC, Amsterdam UMC, Dept Radiol & Nucl Med, Amsterdam, Netherlands.
Schmaal, Lianne (författare)
Orygen, Natl Ctr Excellence Youth Mental Hlth, Parkville, Vic, Australia.;Univ Melbourne, Ctr Youth Mental Hlth, Parkville, Vic, Australia.
Sinha, Rajita (författare)
Yale Univ, Sch Med, Dept Psychiat, New Haven, CT 06520 USA.;Yale Univ, Sch Med, Dept Neurosci, New Haven, CT 06520 USA.
Solowij, Nadia (författare)
Univ Wollongong, Sch Psychol, Wollongong, NSW, Australia.;Univ Wollongong, Illawarra Hlth & Med Res Inst, Wollongong, NSW, Australia.;Australian Ctr Cannabinoid Clin & Res Excellence, New Lambton Hts, NSW, Australia.
Stein, Dan J. (författare)
Univ Cape Town, SA MRC Unit Risk & Resilience Mental Disorders, Dept Psychiat, Cape Town, South Africa.;Univ Cape Town, Inst Neurosci, Cape Town, South Africa.
Stein, Elliot A. (författare)
NIDA, Neuroimaging Res Branch, Intramural Res Program, Baltimore, MD USA.
Tang, Deborah (författare)
McGill Univ, McConnell Brain Imaging Ctr, Montreal Neurol Inst, Montreal, PQ, Canada.
Uhlmann, Anne (författare)
Univ Cape Town, Fac Hlth Sci, Dept Psychiat & Mental Hlth, Cape Town, South Africa.
van Holst, Ruth (författare)
Univ Amsterdam, Dept Psychiat, Amsterdam, Netherlands.
Veltman, Dick J. (författare)
Vrije Univ Amsterdam Med Ctr, Dept Psychiat, Amsterdam, Netherlands.
Verdejo-Garcia, Antonio (författare)
Monash Univ, Turner Inst Brain & Mental Hlth, Sch Psychol Sci, Clayton, Vic, Australia.
Wiers, Reinout W. (författare)
Univ Amsterdam, Addict Dev & Psychopathol ADAPT Lab, Amsterdam, Netherlands.
Yuecel, Murat (författare)
Monash Univ, Turner Inst Brain & Mental Hlth, Sch Psychol Sci, Clayton, Vic, Australia.
Thompson, Paul M. (författare)
Univ Southern Calif, Mark & Mary Stevens Neuroimaging & Informat Inst, Imaging Genet Ctr, Dept Neurol,Keck Sch Med, Los Angeles, CA USA.
Conrod, Patricia (författare)
Univ Montreal, Dept Psychiat, CHU Ste Justine Hosp, Montreal, PQ, Canada.
Garavan, Hugh (författare)
Univ Vermont, Dept Psychiat, Burlington, VT 05405 USA.
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Monash Univ, Turner Inst Brain & Mental Hlth, Sch Psychol Sci, Clayton, Vic, Australia Univ Vermont, Dept Psychiat, Burlington, VT 05405 USA. (creator_code:org_t)
WILEY, 2020
2020
Engelska.
Ingår i: Addiction Biology. - : WILEY. - 1355-6215 .- 1369-1600. ; 25:6
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • While imaging studies have demonstrated volumetric differences in subcortical structures associated with dependence on various abused substances, findings to date have not been wholly consistent. Moreover, most studies have not compared brain morphology across those dependent on different substances of abuse to identify substance-specific and substance-general dependence effects. By pooling large multinational datasets from 33 imaging sites, this study examined subcortical surface morphology in 1628 nondependent controls and 2277 individuals with dependence on alcohol, nicotine, cocaine, methamphetamine, and/or cannabis. Subcortical structures were defined by FreeSurfer segmentation and converted to a mesh surface to extract two vertex-level metrics-the radial distance (RD) of the structure surface from a medial curve and the log of the Jacobian determinant (JD)-that, respectively, describe local thickness and surface area dilation/contraction. Mega-analyses were performed on measures of RD and JD to test for the main effect of substance dependence, controlling for age, sex, intracranial volume, and imaging site. Widespread differences between dependent users and nondependent controls were found across subcortical structures, driven primarily by users dependent on alcohol. Alcohol dependence was associated with localized lower RD and JD across most structures, with the strongest effects in the hippocampus, thalamus, putamen, and amygdala. Meanwhile, nicotine use was associated with greater RD and JD relative to nonsmokers in multiple regions, with the strongest effects in the bilateral hippocampus and right nucleus accumbens. By demonstrating subcortical morphological differences unique to alcohol and nicotine use, rather than dependence across all substances, results suggest substance-specific relationships with subcortical brain structures.

Ämnesord

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Psychiatry (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Psykiatri (hsv//swe)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine (hsv//eng)

Nyckelord

addiction
structural MRI
substance dependence

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