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Sökning: onr:"swepub:oai:DiVA.org:uu-441121" > The Value of Real-W...

The Value of Real-World Data in Understanding Prostate Cancer Risk and Improving Clinical Care : Examples from Swedish Registries

Beckmann, Kerri (författare)
Univ South Australia, Allied Hlth & Human Performance, Canc Epidemiol & Populat Hlth Res Grp, Adelaide, SA 5001, Australia; Kings Coll London, Sch Canc & Pharmaceut Studies, Translat Oncol & Urol Res, London SE1 9RT, England
Garmo, Hans (författare)
Kings Coll London, Sch Canc & Pharmaceut Studies, Translat Oncol & Urol Res, London SE1 9RT, England; Uppsala Univ Hosp, Reg Canc Ctr, SE-75122 Uppsala, Sweden
Franck Lissbrant, Ingela, 1969 (författare)
Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för onkologi,Institute of Clinical Sciences, Department of Oncology
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Stattin, Pär (författare)
Uppsala universitet,Urologkirurgi
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 (creator_code:org_t)
2021-02-19
2021
Engelska.
Ingår i: Cancers. - : MDPI. - 2072-6694. ; 13:4
  • Forskningsöversikt (refereegranskat)
Abstract Ämnesord
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  • Simple SummaryReal-world data (RWD), i.e., data reflecting normal clinical practice collected outside the constraints of randomised controlled trials, provide important insights into our understanding of prostate cancer and its management. Clinical cancer registries are an important source of RWD. Depending on their scope and the potential linkage to other data sources, registry-based data can be utilised to address a variety of questions including risk factors, healthcare utilisation, treatment effectiveness, adverse effects, disparities in healthcare access, quality of care and healthcare economics. This review describes the various registry-based RWD sources for prostate cancer research in Sweden (namely the National Prostate Cancer Register, the Prostate Cancer data Base Sweden (PCBaSe) and the Patient-overview Prostate Cancer) and documents their utility for better understanding prostate cancer aetiology and improving clinical care.AbstractReal-world data (RWD), that is, data from sources other than controlled clinical trials, play an increasingly important role in medical research. The development of quality clinical registers, increasing access to administrative data sources, growing computing power and data linkage capacities have contributed to greater availability of RWD. Evidence derived from RWD increases our understanding of prostate cancer (PCa) aetiology, natural history and effective management. While randomised controlled trials offer the best level of evidence for establishing the efficacy of medical interventions and making causal inferences, studies using RWD offer complementary evidence about the effectiveness, long-term outcomes and safety of interventions in real-world settings. RWD provide the only means of addressing questions about risk factors and exposures that cannot be “controlled”, or when assessing rare outcomes. This review provides examples of the value of RWD for generating evidence about PCa, focusing on studies using data from a quality clinical register, namely the National Prostate Cancer Register (NPCR) Sweden, with longitudinal data on advanced PCa in Patient-overview Prostate Cancer (PPC) and data linkages to other sources in Prostate Cancer data Base Sweden (PCBaSe).

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Urology and Nephrology (hsv//eng)

Nyckelord

prostate cancer
management
risk
real-world data
clinical registry
administrative data
Administrative data
Clinical registry
Management
Prostate cancer
Real-world data
Risk

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Beckmann, Kerri
Garmo, Hans
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Stattin, Pär
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