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Sökning: onr:"swepub:oai:DiVA.org:uu-449346" > The Mastigamoeba ba...

  • Zarsky, VojtechCharles Univ Prague, Fac Sci, Dept Parasitol, BIOCEV, Vestec, Czech Republic. (författare)

The Mastigamoeba balamuthi Genome and the Nature of the Free-Living Ancestor of Entamoeba

  • Artikel/kapitelEngelska2021

Förlag, utgivningsår, omfång ...

  • 2021-02-02
  • Oxford University Press,2021
  • electronicrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:uu-449346
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-449346URI
  • https://doi.org/10.1093/molbev/msab020DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • The transition of free-living organisms to parasitic organisms is a mysterious process that occurs in all major eukaryotic lineages. Parasites display seemingly unique features associated with their pathogenicity; however, it is important to distinguish ancestral preconditions to parasitism from truly new parasite-specific functions. Here, we sequenced the genome and transcriptome of anaerobic free-living Mastigamoeba balamuthi and performed phylogenomic analysis of four related members of the Archamoebae, including Entamoeba histolytica, an important intestinal pathogen of humans. We aimed to trace gene histories throughout the adaptation of the aerobic ancestor of Archamoebae to anaerobiosis and throughout the transition from a free-living to a parasitic lifestyle. These events were associated with massive gene losses that, in parasitic lineages, resulted in a reduction in structural features, complete losses of some metabolic pathways, and a reduction in metabolic complexity. By reconstructing the features of the common ancestor of Archamoebae, we estimated preconditions for the evolution of parasitism in this lineage. The ancestor could apparently form chitinous cysts, possessed proteolytic enzyme machinery, compartmentalized the sulfate activation pathway in mitochondrion-related organelles, and possessed the components for anaerobic energy metabolism. After the split of Entamoebidae, this lineage gained genes encoding surface membrane proteins that are involved in host-parasite interactions. In contrast, gene gains identified in the M. balamuthi lineage were predominantly associated with polysaccharide catabolic processes. A phylogenetic analysis of acquired genes suggested an essential role of lateral gene transfer in parasite evolution (Entamoeba) and in adaptation to anaerobic aquatic sediments (Mastigamoeba).

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Klimes, VladimirUniv Ostrava, Fac Sci, Dept Biol & Ecol, Ostrava, Czech Republic. (författare)
  • Paces, JanAcad Sci Czech Republ, Inst Mol Genet, Prague, Czech Republic. (författare)
  • Vlcek, CestmirAcad Sci Czech Republ, Inst Mol Genet, Prague, Czech Republic. (författare)
  • Hradilova, MiluseAcad Sci Czech Republ, Inst Mol Genet, Prague, Czech Republic. (författare)
  • Benes, VladimirEuropean Mol Biol Lab EMBL, Genom Core Facil, Heidelberg, Germany. (författare)
  • Nyvltova, EvaCharles Univ Prague, Fac Sci, Dept Parasitol, BIOCEV, Vestec, Czech Republic. (författare)
  • Hrdy, IvanCharles Univ Prague, Fac Sci, Dept Parasitol, BIOCEV, Vestec, Czech Republic. (författare)
  • Pyrih, JanCharles Univ Prague, Fac Sci, Dept Parasitol, BIOCEV, Vestec, Czech Republic. (författare)
  • Mach, JanCharles Univ Prague, Fac Sci, Dept Parasitol, BIOCEV, Vestec, Czech Republic. (författare)
  • Barlow, LaelUniv Alberta, Dept Biol Sci, Edmonton, AB, Canada. (författare)
  • Stairs, Courtney W.Uppsala universitet,Molekylär evolution,Dalhousie Univ, Dept Biochem & Mol Biol, Halifax, NS, Canada.(Swepub:uu)coust885 (författare)
  • Eme, LauraUniv Paris Saclay, Divers Ecol & Evolut Microbes DEEM, Unite Ecol Systemat Evolut, Orsay, France. (författare)
  • Hall, NeilEarlham Inst, Norwich Res Pk, Norwich, Norfolk, England.;Univ East Anglia, Sch Biol Sci, Norwich Res Pk, Norwich, Norfolk, England. (författare)
  • Elias, MarekUniv Ostrava, Fac Sci, Dept Biol & Ecol, Ostrava, Czech Republic. (författare)
  • Dacks, Joel B.Univ Alberta, Dept Biol Sci, Edmonton, AB, Canada.;Univ Alberta, Dept Med, Div Infect Dis, Edmonton, AB, Canada.;CAS vvi, Inst Parasitol, Biol Ctr, Ceske Budejovice, Czech Republic. (författare)
  • Roger, AndrewDalhousie Univ, Dept Biochem & Mol Biol, Halifax, NS, Canada. (författare)
  • Tachezy, JanCharles Univ Prague, Fac Sci, Dept Parasitol, BIOCEV, Vestec, Czech Republic. (författare)
  • Charles Univ Prague, Fac Sci, Dept Parasitol, BIOCEV, Vestec, Czech Republic.Univ Ostrava, Fac Sci, Dept Biol & Ecol, Ostrava, Czech Republic. (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Molecular biology and evolution: Oxford University Press38:6, s. 2240-22590737-40381537-1719

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