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Sökning: onr:"swepub:oai:DiVA.org:uu-449346" > The Mastigamoeba ba...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00005751naa a2200601 4500
001oai:DiVA.org:uu-449346
003SwePub
008210723s2021 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4493462 URI
0247 a https://doi.org/10.1093/molbev/msab0202 DOI
040 a (SwePub)uu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Zarsky, Vojtechu Charles Univ Prague, Fac Sci, Dept Parasitol, BIOCEV, Vestec, Czech Republic.4 aut
2451 0a The Mastigamoeba balamuthi Genome and the Nature of the Free-Living Ancestor of Entamoeba
264 c 2021-02-02
264 1b Oxford University Press,c 2021
338 a electronic2 rdacarrier
520 a The transition of free-living organisms to parasitic organisms is a mysterious process that occurs in all major eukaryotic lineages. Parasites display seemingly unique features associated with their pathogenicity; however, it is important to distinguish ancestral preconditions to parasitism from truly new parasite-specific functions. Here, we sequenced the genome and transcriptome of anaerobic free-living Mastigamoeba balamuthi and performed phylogenomic analysis of four related members of the Archamoebae, including Entamoeba histolytica, an important intestinal pathogen of humans. We aimed to trace gene histories throughout the adaptation of the aerobic ancestor of Archamoebae to anaerobiosis and throughout the transition from a free-living to a parasitic lifestyle. These events were associated with massive gene losses that, in parasitic lineages, resulted in a reduction in structural features, complete losses of some metabolic pathways, and a reduction in metabolic complexity. By reconstructing the features of the common ancestor of Archamoebae, we estimated preconditions for the evolution of parasitism in this lineage. The ancestor could apparently form chitinous cysts, possessed proteolytic enzyme machinery, compartmentalized the sulfate activation pathway in mitochondrion-related organelles, and possessed the components for anaerobic energy metabolism. After the split of Entamoebidae, this lineage gained genes encoding surface membrane proteins that are involved in host-parasite interactions. In contrast, gene gains identified in the M. balamuthi lineage were predominantly associated with polysaccharide catabolic processes. A phylogenetic analysis of acquired genes suggested an essential role of lateral gene transfer in parasite evolution (Entamoeba) and in adaptation to anaerobic aquatic sediments (Mastigamoeba).
650 7a NATURVETENSKAPx Biologix Evolutionsbiologi0 (SwePub)106152 hsv//swe
650 7a NATURAL SCIENCESx Biological Sciencesx Evolutionary Biology0 (SwePub)106152 hsv//eng
653 a evolution of parasitism
653 a lateral gene transfer
653 a pathway complexity
653 a Archamoebae
653 a chitinous cysts
653 a Mastigamoeba
7001 a Klimes, Vladimiru Univ Ostrava, Fac Sci, Dept Biol & Ecol, Ostrava, Czech Republic.4 aut
7001 a Paces, Janu Acad Sci Czech Republ, Inst Mol Genet, Prague, Czech Republic.4 aut
7001 a Vlcek, Cestmiru Acad Sci Czech Republ, Inst Mol Genet, Prague, Czech Republic.4 aut
7001 a Hradilova, Miluseu Acad Sci Czech Republ, Inst Mol Genet, Prague, Czech Republic.4 aut
7001 a Benes, Vladimiru European Mol Biol Lab EMBL, Genom Core Facil, Heidelberg, Germany.4 aut
7001 a Nyvltova, Evau Charles Univ Prague, Fac Sci, Dept Parasitol, BIOCEV, Vestec, Czech Republic.4 aut
7001 a Hrdy, Ivanu Charles Univ Prague, Fac Sci, Dept Parasitol, BIOCEV, Vestec, Czech Republic.4 aut
7001 a Pyrih, Janu Charles Univ Prague, Fac Sci, Dept Parasitol, BIOCEV, Vestec, Czech Republic.4 aut
7001 a Mach, Janu Charles Univ Prague, Fac Sci, Dept Parasitol, BIOCEV, Vestec, Czech Republic.4 aut
7001 a Barlow, Laelu Univ Alberta, Dept Biol Sci, Edmonton, AB, Canada.4 aut
7001 a Stairs, Courtney W.u Uppsala universitet,Molekylär evolution,Dalhousie Univ, Dept Biochem & Mol Biol, Halifax, NS, Canada.4 aut0 (Swepub:uu)coust885
7001 a Eme, Laurau Univ Paris Saclay, Divers Ecol & Evolut Microbes DEEM, Unite Ecol Systemat Evolut, Orsay, France.4 aut
7001 a Hall, Neilu Earlham Inst, Norwich Res Pk, Norwich, Norfolk, England.;Univ East Anglia, Sch Biol Sci, Norwich Res Pk, Norwich, Norfolk, England.4 aut
7001 a Elias, Mareku Univ Ostrava, Fac Sci, Dept Biol & Ecol, Ostrava, Czech Republic.4 aut
7001 a Dacks, Joel B.u Univ Alberta, Dept Biol Sci, Edmonton, AB, Canada.;Univ Alberta, Dept Med, Div Infect Dis, Edmonton, AB, Canada.;CAS vvi, Inst Parasitol, Biol Ctr, Ceske Budejovice, Czech Republic.4 aut
7001 a Roger, Andrewu Dalhousie Univ, Dept Biochem & Mol Biol, Halifax, NS, Canada.4 aut
7001 a Tachezy, Janu Charles Univ Prague, Fac Sci, Dept Parasitol, BIOCEV, Vestec, Czech Republic.4 aut
7102 a Charles Univ Prague, Fac Sci, Dept Parasitol, BIOCEV, Vestec, Czech Republic.b Univ Ostrava, Fac Sci, Dept Biol & Ecol, Ostrava, Czech Republic.4 org
7730 t Molecular biology and evolutiond : Oxford University Pressg 38:6, s. 2240-2259q 38:6<2240-2259x 0737-4038x 1537-1719
8564 u https://doi.org/10.1093/molbev/msab020y Fulltext
8564 u https://uu.diva-portal.org/smash/get/diva2:1581700/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 u https://academic.oup.com/mbe/article-pdf/38/6/2240/37986772/msab020.pdf
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-449346
8564 8u https://doi.org/10.1093/molbev/msab020

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