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Patient-reported Si...
Patient-reported Side Effects 1 Year After Radical Prostatectomy or Radiotherapy for Prostate Cancer : A Register-based Nationwide Study
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- Corsini, Christian (författare)
- Uppsala University,Uppsala universitet,Institutionen för kirurgiska vetenskaper,IRCCS San Raffaele Hosp, Urol Res Inst, Div Expt Oncol, Unit Urol, Milan, Italy.,Department of Surgical Sciences, Uppsala University, Uppsala, Sweden; Division of Experimental Oncology/Unit of Urology, Urological Research Institute, IRCCS San Raffaele Hospital, Milan, Italy
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- Bergengren, Oskar (författare)
- Uppsala University,Uppsala universitet,Urologkirurgi,Department of Surgical Sciences, Uppsala University, Uppsala, Sweden
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- Carlsson, Stefan (författare)
- Karolinska Univ Hosp, Dept Urol, Solna, Sweden.,Department of Urology, Karolinska University Hospital, Solna, Sweden
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- Garmo, Hans (författare)
- Uppsala University,Uppsala universitet,Urologkirurgi,Department of Surgical Sciences, Uppsala University, Uppsala, Sweden
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- Hjelm-Eriksson, Marie (författare)
- St Goran Hosp, Dept Oncol, Stockholm, Sweden.,Department of Oncology, St. Göran Hospital, Stockholm, Sweden,Capio St. Görans Sjukhus
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- Fransson, Per (författare)
- Umeå University,Umeå universitet,Institutionen för omvårdnad,Cancercentrum, Norrlands University Hospital, Umeå, Sweden,Umeå Univ, Dept Nursing, Umeå, Sweden.;Norrlands Univ Hosp, Canc Ctr, Umeå, Sweden.
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- Kindblom, Jon, 1969 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för onkologi,Institute of Clinical Sciences, Department of Oncology
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- Robinson, David (författare)
- Ryhov Hosp, Dept Urol, Jönköping, Sweden.,Department of Urology, Ryhov Hospital, Jönköping, Sweden,Ryhov County Hospital, Jönköping
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- Westerberg, Marcus, 1990- (författare)
- Uppsala University,Uppsala universitet,Urologkirurgi,Department of Surgical Sciences, Uppsala University, Uppsala, Sweden
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- Stattin, Pär (författare)
- Uppsala University,Uppsala universitet,Urologkirurgi,Department of Surgical Sciences, Uppsala University, Uppsala, Sweden
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- Carlsson, Sigrid V. (författare)
- Gothenburg University,Göteborgs universitet,University of Gothenburg,Lund University,Lunds universitet,Urologisk cancerforskning, Malmö,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Urological cancer, Malmö,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Memorial Sloan-Kettering Cancer Center,Mem Sloan Kettering Canc Ctr, Dept Surg Urol Serv, 1133 York Ave, New York, NY 10065 USA.;Mem Sloan Kettering Canc Ctr, Dept Epidemiol & Biostat, New York, NY USA.;Gothenburg Univ, Sahlgrenska Acad, Dept Urol, Gothenburg, Sweden.;Lund Univ, Med Fac, Dept Translat Med, Div Urol Canc, Lund, Sweden.,Institutionen för kliniska vetenskaper, Avdelningen för urologi,Institute of Clinical Sciences, Department of Urology
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(creator_code:org_t)
- Elsevier, 2024
- 2024
- Engelska.
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Ingår i: European Urology Oncology. - : Elsevier. - 2588-9311. ; 7:3, s. 605-613
- Relaterad länk:
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https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
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http://dx.doi.org/10... (free)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://lup.lub.lu.s...
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https://gup.ub.gu.se...
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Abstract
Ämnesord
Stäng
- Background: Data on functional and psychological side effects following curative treatment for prostate cancer are lacking from large, contemporary, unselected, populationbased cohorts. Objective: To assess urinary symptoms, bowel disturbances, erectile dysfunction (ED), and quality of life (QoL) 12 mo after robot -assisted radical prostatectomy (RARP) and radiotherapy (RT) using patient -reported outcome measures in the Swedish prostate cancer database. Design, setting, and participants: This was a nationwide, population -based, cohort study in Sweden of men who underwent primary RARP or RT between January 1, 2018 and December 31, 2020. Outcome measurements and statistical analysis: Absolute proportions and odds ratios (ORs) were calculated using multivariable logistic regression, with adjustment for clinical characteristics. Results and limitations: A total of 2557 men underwent RARP and 1741 received RT. Men who underwent RT were older (69 vs 65 yr) and had more comorbidities at baseline. After RARP, 13% of men experienced incontinence, compared to 6% after RT. The frequency of urinary bother was similar, at 18% after RARP and 18% after RT. Urgency to defecate was reported by 14% of men after RARP and 34% after RT. At 1 yr, 73% of men had ED after RARP, and 77% after RT. High QoL was reported by 85% of men after RARP and 78% of men after RT. On multivariable regression analysis, RT was associated with lower risks of urinary incontinence (OR 0.25, 95% confidence interval [CI] 0.19- 0.33), urinary bother (OR 0.79, 95% CI 0.66-0.95), and ED (OR 0.54, 95% CI 0.46-0.65), but higher risk of bowel symptoms (OR 2.86, 95% CI 2.42-3.39). QoL was higher after RARP than after RT (OR 1.34, 95% CI 1.12-1.61). Conclusions: Short-term specific side effects after curative treatment for prostate cancer significantly differed between RARP and RT in this large and unselected cohort. Nevertheless, the risk of urinary bother was lower after RT, while higher QoL was common after RARP. Patient summary: In our study of patients treated for prostate cancer, urinary bother and overall quality of life are comparable at 1 year after surgical removal of the prostate in comparison to radiotherapy, despite substantial differences in other side effects. (c) 2024 The Authors. Published by Elsevier B.V. on behalf of European Association of Urology. This is an open access article under the CC BY -NC -ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Urology and Nephrology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Omvårdnad (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nursing (hsv//eng)
Nyckelord
- Prostate cancer
- Radical prostatectomy
- Radiotherapy
- Patient-reported outcomes
- Population-based study
- Patient-reported outcomes
- Population-based study
- Prostate cancer
- Radical prostatectomy
- Radiotherapy
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- art (ämneskategori)
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Corsini, Christi ...
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Bergengren, Oska ...
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Carlsson, Stefan
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Garmo, Hans
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Hjelm-Eriksson, ...
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Fransson, Per
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Kindblom, Jon, 1 ...
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Robinson, David
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Westerberg, Marc ...
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Stattin, Pär
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Carlsson, Sigrid ...
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och Cancer och onkol ...
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MEDICIN OCH HÄLS ...
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och Urologi och njur ...
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European Urology ...
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Uppsala universitet
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Umeå universitet
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Lunds universitet
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Göteborgs universitet