Spatial evidence for carcinoma in situ (CIS) as an entity in human papillomavirus (HPV)-associated tonsillar squamous cell carcinoma (TSCC)

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Näsman, TobiasKarolinska Univ Hosp, Karolinska Inst, Dept Oncol Pathol, Stockholm, Sweden.;Karolinska Univ Hosp, Karolinska Univ Lab KUL, Dept Clin Pathol & Canc Diagnost, Stockholm, Sweden. (författare)

Spatial evidence for carcinoma in situ (CIS) as an entity in human papillomavirus (HPV)-associated tonsillar squamous cell carcinoma (TSCC)

Artikel/kapitelEngelska2026

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John Wiley & Sons,2026
electronicrdacarrier

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LIBRIS-ID:oai:DiVA.org:uu-583664
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-583664URI
https://doi.org/10.1002/ijc.70207DOI
https://ki.se/en/research/search-research-information?t=2&query=id%3A1072777URI

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Språk:engelska
Sammanfattning på:engelska

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Human papillomavirus (HPV)-associated tonsillar squamous cell carcinoma (TSCC) is suggested to arise in tonsillar crypts. It also constitutes a rare exception in the literature of carcinoma development, as carcinoma in situ (CIS) is not a recognized entity and dysplastic stages are not evident. Here we investigated the evidence of this. Hence, a systematic review and meta-analysis was performed to study tumor origin. MEDLINE was searched and all original studies reporting tumor origin in HPV-associated oropharyngeal cancer were included. We also used spatial transcriptomics (10x Visium) on HPV-associated TSCC, cervical, and HPV-independent oral cancer cases. We compared tonsillar CIS to cervical high-grade intraepithelial lesion (HSIL). We studied epithelial cell gene expression across the sample types and epithelial cellular states. A trajectory analysis was performed in HPV-associated tumors. In total, 14% of all TSCC were of surface origin in the systematic review. Spatial transcriptomics revealed that tonsillar CIS and HSIL clustered with a high correlation when using a pseudo-bulk approach. Moreover, when all epithelial cells were analyzed unsupervised, ten epithelial cell clusters that correlated to histology were identified. Two of these clusters were dysplastic and occurred in all samples. A sequential progression from dysplasia to invasion was observed in both TSCC and cervical cancer in the trajectory analysis. We conclude that a subset of HPV-associated TSCC may arise from the surface and that there is a sequential progression toward invasive disease in HPV-associated TSCC, similar to that of cervical cancer. The findings suggest that pure tonsillar dysplastic lesions should hypothetically exist.

Ämnesord och genrebeteckningar

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Cancer och onkologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Cancer and Oncology hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Infektionsmedicin hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Infectious Medicine hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Oto-rhino-laryngologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Oto-rhino-laryngology hsv//eng
carcinoma in situ
dysplasia
human papillomavirus
oropharyngeal
tonsil

Biuppslag (personer, institutioner, konferenser, titlar ...)

Birgersson, MKarolinska Univ Hosp, Karolinska Inst, Dept Oncol Pathol, Stockholm, Sweden.,Department of Clinical Science, Intervention and Technology (CLINTEC),Department of Clinical Science, Intervention and Technology (CLINTEC)(Swepub:ki)138840b8f8ff2c264051d5f9bddf044e (författare)
Marklund, LindaUppsala universitet,Öron-, näs- och halssjukdomar,Karolinska Univ Hosp, Med Unit Head Neck Lung & Skin Canc, Theme Canc, Stockholm, Sweden; Karolinska Inst, Dept Clin Sci Intervent & Technol, Div ENT Dis, Stockholm, Sweden,Department of Clinical Science, Intervention and Technology (CLINTEC),Department of Clinical Science, Intervention and Technology (CLINTEC)(Swepub:ki)79046be8e76509cbcb066c6768836dcb (författare)
Näsman, AndersKarolinska Univ Hosp, Karolinska Inst, Dept Oncol Pathol, Stockholm, Sweden.;Karolinska Univ Hosp, Karolinska Univ Lab KUL, Dept Clin Pathol & Canc Diagnost, Stockholm, Sweden. (författare)
Karolinska Univ Hosp, Karolinska Inst, Dept Oncol Pathol, Stockholm, Sweden.;Karolinska Univ Hosp, Karolinska Univ Lab KUL, Dept Clin Pathol & Canc Diagnost, Stockholm, Sweden.Karolinska Univ Hosp, Karolinska Inst, Dept Oncol Pathol, Stockholm, Sweden. (creator_code:org_t)

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Ingår i:International Journal of Cancer: John Wiley & Sons158:4, s. 1080-10920020-71361097-0215

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Av författaren/redakt...: Näsman, Tobias; Birgersson, M; Marklund, Linda; Näsman, Anders

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Cancer och onkol ...

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