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Sökning: onr:"swepub:oai:DiVA.org:uu-583664" > Spatial evidence fo...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00005336naa a2200481 4500
001oai:DiVA.org:uu-583664
003SwePub
008260407s2026 | |||||||||||000 ||eng|
009oai:swepub.ki.se:1072777
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-5836642 URI
0247 a https://doi.org/10.1002/ijc.702072 DOI
0247 a https://ki.se/en/research/search-research-information?t=2&query=id%3A10727772 URI
040 a (SwePub)uud (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Näsman, Tobiasu Karolinska Univ Hosp, Karolinska Inst, Dept Oncol Pathol, Stockholm, Sweden.;Karolinska Univ Hosp, Karolinska Univ Lab KUL, Dept Clin Pathol & Canc Diagnost, Stockholm, Sweden.4 aut
2451 0a Spatial evidence for carcinoma in situ (CIS) as an entity in human papillomavirus (HPV)-associated tonsillar squamous cell carcinoma (TSCC)
264 1b John Wiley & Sons,c 2026
338 a electronic2 rdacarrier
520 a Human papillomavirus (HPV)-associated tonsillar squamous cell carcinoma (TSCC) is suggested to arise in tonsillar crypts. It also constitutes a rare exception in the literature of carcinoma development, as carcinoma in situ (CIS) is not a recognized entity and dysplastic stages are not evident. Here we investigated the evidence of this. Hence, a systematic review and meta-analysis was performed to study tumor origin. MEDLINE was searched and all original studies reporting tumor origin in HPV-associated oropharyngeal cancer were included. We also used spatial transcriptomics (10x Visium) on HPV-associated TSCC, cervical, and HPV-independent oral cancer cases. We compared tonsillar CIS to cervical high-grade intraepithelial lesion (HSIL). We studied epithelial cell gene expression across the sample types and epithelial cellular states. A trajectory analysis was performed in HPV-associated tumors. In total, 14% of all TSCC were of surface origin in the systematic review. Spatial transcriptomics revealed that tonsillar CIS and HSIL clustered with a high correlation when using a pseudo-bulk approach. Moreover, when all epithelial cells were analyzed unsupervised, ten epithelial cell clusters that correlated to histology were identified. Two of these clusters were dysplastic and occurred in all samples. A sequential progression from dysplasia to invasion was observed in both TSCC and cervical cancer in the trajectory analysis. We conclude that a subset of HPV-associated TSCC may arise from the surface and that there is a sequential progression toward invasive disease in HPV-associated TSCC, similar to that of cervical cancer. The findings suggest that pure tonsillar dysplastic lesions should hypothetically exist.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Infektionsmedicin0 (SwePub)302092 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Infectious Medicine0 (SwePub)302092 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Oto-rhino-laryngologi0 (SwePub)302182 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Oto-rhino-laryngology0 (SwePub)302182 hsv//eng
653 a carcinoma in situ
653 a dysplasia
653 a human papillomavirus
653 a oropharyngeal
653 a tonsil
7001 a Birgersson, Mu Karolinska Univ Hosp, Karolinska Inst, Dept Oncol Pathol, Stockholm, Sweden.,Department of Clinical Science, Intervention and Technology (CLINTEC),Department of Clinical Science, Intervention and Technology (CLINTEC)4 aut0 (Swepub:ki)138840b8f8ff2c264051d5f9bddf044e
7001 a Marklund, Lindau Uppsala universitet,Öron-, näs- och halssjukdomar,Karolinska Univ Hosp, Med Unit Head Neck Lung & Skin Canc, Theme Canc, Stockholm, Sweden; Karolinska Inst, Dept Clin Sci Intervent & Technol, Div ENT Dis, Stockholm, Sweden,Department of Clinical Science, Intervention and Technology (CLINTEC),Department of Clinical Science, Intervention and Technology (CLINTEC)4 aut0 (Swepub:ki)79046be8e76509cbcb066c6768836dcb
7001 a Näsman, Andersu Karolinska Univ Hosp, Karolinska Inst, Dept Oncol Pathol, Stockholm, Sweden.;Karolinska Univ Hosp, Karolinska Univ Lab KUL, Dept Clin Pathol & Canc Diagnost, Stockholm, Sweden.4 aut
7102 a Karolinska Univ Hosp, Karolinska Inst, Dept Oncol Pathol, Stockholm, Sweden.;Karolinska Univ Hosp, Karolinska Univ Lab KUL, Dept Clin Pathol & Canc Diagnost, Stockholm, Sweden.b Karolinska Univ Hosp, Karolinska Inst, Dept Oncol Pathol, Stockholm, Sweden.4 org
7730 t International Journal of Cancerd : John Wiley & Sonsg 158:4, s. 1080-1092q 158:4<1080-1092x 0020-7136x 1097-0215
8564 u https://doi.org/10.1002/ijc.70207y Fulltext
8564 u https://uu.diva-portal.org/smash/get/diva2:2051185/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-583664
8564 8u https://doi.org/10.1002/ijc.70207
8564 8u https://ki.se/en/research/search-research-information?t=2&query=id%3A1072777

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Näsman, Tobias
Birgersson, M
Marklund, Linda
Näsman, Anders
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