Adipokines: a link between obesity and dementia?

• Being overweight or obese, as measured with body-mass index or central adiposity (waist circumference), and the trajectory of body-mass index over the life course have been associated with brain atrophy, white matter changes, disturbances of blood brain barrier integrity, and risk of all-cause late-onset dementia and Alzheimer's disease. This observation leads us to question what it is about body-mass index that is associated with health of the brain and dementia risk. If high body-mass index and central adiposity represent an increase in adipose tissue, then the endocrine function of adipose tissue, mediated by adipose tissue hormones and adipokines, could be a due to mechanisms that underlie the association with dementia and Alzheimer's disease. Hundreds of adipoldnes have been identified, creating a complexity that is a challenge to simplify. Nonetheless, adipokines are being investigated in association with clinical dementia outcomes, and with imaging-based measures of brain volume, structure, and function in human beings and in predinical models of clinical dementia.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine (hsv//eng)

Nyckelord

HEPATOCYTE GROWTH-FACTOR

PLASMINOGEN-ACTIVATOR INHIBITOR-1

BODY-MASS

INDEX

MILD COGNITIVE IMPAIRMENT

INCIDENT ALZHEIMER-DISEASE

FOCAL

CEREBRAL-ISCHEMIA

TRAUMATIC BRAIN-INJURY

CENTRAL-NERVOUS-SYSTEM

HUMAN

CEREBROSPINAL-FLUID

VASCULAR RISK-FACTORS

Clinical Neurology

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