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LIBRIS Formathandbok  (Information om MARC21)
00008073naa a2201021 4500
008210529s2017 | |||||||||||000 ||eng|
024a https://gup.ub.gu.se/publication/2662562 URI
024a https://doi.org/10.1177/23969873177032102 DOI
024a https://lup.lub.lu.se/record/fce74cee-9719-46fa-9df6-ccf15e744f682 URI
040 a (SwePub)gud (SwePub)lu
041 a eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
100a Putaala, Jukkau Helsinki University Central Hospital4 aut0 (Swepub:gu)735013
2451 0a Searching for Explanations for Cryptogenic Stroke in the Young: Revealing the Triggers, Causes, and Outcome (SECRETO): Rationale and design
264 1b SAGE Publications,c 2017
520 a Background: Worldwide, about 1.3 million annual ischaemic strokes (IS) occur in adults aged <50 years. Of theseearly-onset strokes, up to 50% can be regarded as cryptogenic or associated with conditions with poorly documented causality like patent foramen ovale and coagulopathies. Key hypotheses/aims: (1) Investigate transient triggers and clinical/sub-clinical chronic risk factors associated with cryptogenic IS in the young; (2) use cardiac imaging methods exceeding state-of-the-art to reveal novel sources for embolism; (3) search for covert thrombosis and haemostasis abnormalities; (4) discover new disease pathways using next-generation sequencing and RNA gene expression studies; (5) determine patient prognosis by use of phenotypic and genetic data; and (6) adapt systems medicine approach to investigate complex risk-factor interactions. Design: Searching for Explanations for Cryptogenic Stroke in the Young: Revealing the Etiology, Triggers, and Outcome (SECRETO; NCT01934725) is a prospective multi-centre case–control study enrolling patients aged 18–49 years hospitalised due to first-ever imaging-proven IS of undetermined etiology. Patients are examined according to a standardised protocol and followed up for 10 years. Patients are 1:1 age- and sex-matched to stroke-free controls. Key study elements include centralised reading of echocardiography, electrocardiography, and neurovascular imaging, as well as blood samples for genetic, gene-expression, thrombosis and haemostasis and biomarker analysis. We aim to have 600 patient–control pairs enrolled by the end of 2018. Summary: SECRETO is aiming to establish novel mechanisms and prognosis of cryptogenic IS in the young and will provide new directions for therapy development for these patients. First results are anticipated in 2019.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicin0 (SwePub)3022 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicine0 (SwePub)3022 hsv//eng
653 a Brain infarction
653 a echocardiography
653 a electrocardiography
653 a embolism
653 a middle aged
653 a paradoxical embolism
653 a patent foramen ovale
653 a prognosis
653 a risk factors
653 a stroke
653 a thrombosis
653 a young adult
700a Martinez-Majander, Nicolasu Helsinki University Central Hospital4 aut0 (Swepub:gu)735014
700a Saeed, Sahraiu University of Bergen4 aut0 (Swepub:gu)735015
700a Yesilot, Niluferu Istanbul University4 aut0 (Swepub:gu)735016
700a Jäkälä, Pekkau Kuopio University Hospital4 aut0 (Swepub:gu)735017
700a Nerg, Ossiu Kuopio University Hospital4 aut0 (Swepub:gu)735018
700a Tsivgoulis, Georgiosu National and Kapodistrian University of Athens,Attikon University Hospital4 aut0 (Swepub:gu)735019
700a Numminen, Heikkiu Tampere University Hospital4 aut0 (Swepub:gu)735020
700a Gordin, Danielu University of Helsinki,Folkhälsan Research Center4 aut0 (Swepub:gu)735021
700a von Sarnowski, Bettinau University of Greifswald4 aut0 (Swepub:gu)735022
700a Waje-Andreassen, Ulrikeu Haukeland University Hospital4 aut0 (Swepub:gu)735024
700a Ylikotila, Pauliu University of Turku,Turku University Hospital4 aut0 (Swepub:gu)735025
700a Roine, Risto O4 aut
700a Zedde, Marialuisau Arcispedale Santa Maria Nuova4 aut0 (Swepub:gu)735027
700a Huhtakangas, Juhau Oulu University Hospital4 aut0 (Swepub:gu)735028
700a Fonseca, Catarinau Santa Maria Hospital, Lisbon,University of Lisbon4 aut0 (Swepub:gu)735029
700a Redfors, Petrau University of Gothenburg,Sahlgrenska University Hospital4 aut0 (Swepub:gu)735031
700a de Leeuw, Frank-Erik4 aut
700a Pezzini, Alessandrou University of Brescia4 aut0 (Swepub:gu)735034
700a Korv, Janika4 aut
700a Schneider, Siimu North Estonia Medical Centre4 aut0 (Swepub:gu)735037
700a Tanislav, Christianu Justus Liebig University Giessen4 aut0 (Swepub:gu)735038
700a Enzinger, Christianu Medical University of Graz4 aut0 (Swepub:gu)735039
700a Jatuzis, Daliusu Vilnius University4 aut0 (Swepub:gu)735040
700a Siegerink, Bobu Charité - University Medicine Berlin4 aut0 (Swepub:gu)735041
700a Martínez-Sánchez, Patriciau University Hospital La Paz,Autonomous University of Madrid4 aut0 (Swepub:gu)735042
700a Grau, Armin J4 aut
700a Palm, Fredericku Klinikum Ludwigshafen4 aut0 (Swepub:gu)735045
700a Groop, Per-Henrik4 aut
700a Lanthier, Sylvainu Centre hospitalier de l'Université de Montréal4 aut0 (Swepub:gu)735047
700a Ten Cate, Hugou Maastricht University4 aut0 (Swepub:gu)735048
700a Pussinen, Pirkkou Helsinki University Central Hospital,University of Helsinki4 aut0 (Swepub:gu)735049
700a Paju, Susannau Helsinki University Central Hospital,University of Helsinki4 aut0 (Swepub:gu)735050
700a Sinisalo, Juhau Helsinki University Central Hospital4 aut0 (Swepub:gu)735051
700a Lehto, Mikau Helsinki University Central Hospital4 aut0 (Swepub:gu)735053
700a Lindgren, Arneu Lund University,Lunds universitet,Klinisk strokeforskning,Forskargrupper vid Lunds universitet,Clinical Stroke Research Group,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:gu)735054
700a Ferro, Joséu University of Lisbon,Santa Maria Hospital, Lisbon4 aut0 (Swepub:gu)735055
700a Kittner, Stevenu Baltimore Veterans Administration Medical Center,University of Maryland4 aut0 (Swepub:gu)735056
700a Fazekas, Franzu Medical University of Graz4 aut0 (Swepub:gu)735057
700a Gerdts, Evau University of Bergen4 aut0 (Swepub:gu)735058
700a Tatlisumak, Turgutu University of Gothenburg,Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience,Helsinki University Central Hospital,Sahlgrenska University Hospital4 aut0 (Swepub:gu)xtatlt
700a Grau, Armin J.u Klinikum Ludwigshafen4 aut
700a Kõrv, Janikau University of Tartu4 aut
700a de Leeuw, Frank Eriku Radboud University Medical Center4 aut
700a Groop, Per Henriku University of Helsinki,Folkhälsan Research Center4 aut
700a Roine, Risto O.u Turku University Hospital,University of Turku4 aut
710a Helsinki University Central Hospitalb University of Bergen4 org
710a Göteborgs universitet
710a Gothenburg University
773t European Stroke Journald : SAGE Publicationsg 2:2, s. 116-125q 2:2<116-125x 2396-9873
856u http://dx.doi.org/10.1177/2396987317703210y FULLTEXT
8564 8u https://gup.ub.gu.se/publication/266256
8564 8u https://doi.org/10.1177/2396987317703210
8564 8u https://lup.lub.lu.se/record/fce74cee-9719-46fa-9df6-ccf15e744f68

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