Stanford University,Stanford Univ, Dept Genet, Sch Med, Stanford, CA, USA
Gu Urban, Gucci Jijuan, 1984- (författare)
Uppsala universitet,Molekylära verktyg,Stanford Univ, Dept Genet, Sch Med, Stanford, CA, USA,Stanford University
Mishra, Tejaswini (författare)
Stanford University,Stanford Univ, Dept Genet, Sch Med, Stanford, CA, USA
Hanson, Blake M. (författare)
The Jackson Laboratory for Genomic Medicine,Jackson Lab Genom Med, Farmington, CT, USA
Bautista, Eddy J. (författare)
The Jackson Laboratory for Genomic Medicine,Jackson Lab Genom Med, Farmington, CT, USA; Corp Invest & Agr Corpoica, Ctr Invest Tibaitata, Mosquera, Colombia
Leopold, Shana (författare)
Stanford University,Jackson Lab Genom Med, Farmington, CT, USA
Yeh, Christine Y. (författare)
Stanford University,Stanford Univ, Dept Genet, Sch Med, Stanford, CA, USA; Stanford Univ, Dept Radiol, Sch Med, Stanford, CA, USA; Stanford Univ, Canary Ctr Stanford, Sch Med, Stanford, CA, USA; Stanford Univ, Biomed Informat Program, Sch Med, Stanford, CA, USA
Spakowicz, Daniel (författare)
The Jackson Laboratory for Genomic Medicine,Jackson Lab Genom Med, Farmington, CT, USA
Banerjee, Imon (författare)
Stanford University,Stanford Univ, Dept Biomed Data Sci, Sch Med, Stanford, CA, USA
Chen, Cynthia (författare)
Stanford University,Stanford Univ, Dept Biomed Data Sci, Sch Med, Stanford, CA, USA
Kukurba, Kimberly (författare)
Stanford University,Stanford Univ, Dept Genet, Sch Med, Stanford, CA, USA
Perelman, Dalia (författare)
Stanford University,Stanford Univ, Div Endocrinol, Sch Med, Stanford, CA, USA
Craig, Colleen (författare)
Stanford University,Stanford Univ, Div Endocrinol, Sch Med, Stanford, CA, USA
Colbert, Elizabeth (författare)
Stanford University,Stanford Univ, Div Endocrinol, Sch Med, Stanford, CA, USA
Salins, Denis (författare)
Stanford University,Stanford Univ, Dept Genet, Sch Med, Stanford, CA, USA
Rego, Shannon (författare)
Stanford University,Stanford Univ, Dept Genet, Sch Med, Stanford, CA, USA
Lee, Sunjae (författare)
Kungliga Tekniska Högskolan (KTH),Royal Institute of Technology (KTH),KTH Royal Inst Technol, Sci Life Lab, Stockholm, Sweden
Zhang, Cheng (författare)
KTH,Science for Life Laboratory, SciLifeLab,Kungliga Tekniska Högskolan (KTH),Royal Institute of Technology (KTH),KTH Royal Inst Technol, Sci Life Lab, Stockholm, Sweden
Wheeler, Jessica (författare)
Stanford University,Stanford Univ, Dept Genet, Sch Med, Stanford, CA, USA
Sailani, M. Reza (författare)
Stanford University,Stanford Univ, Dept Genet, Sch Med, Stanford, CA, USA
Rubin, Daniel L. (författare)
Stanford University,Stanford Univ, Dept Genet, Sch Med, Stanford, CA, USA,Stanford Univ, Dept Biomed Data Sci, Sch Med, Stanford, CA, USA
Abbott, Charles (författare)
Stanford University,Stanford Univ, Dept Genet, Sch Med, Stanford, CA, USA
Gerstein, Mark (författare)
Yale University,Yale Univ, Dept Mol Biophys & Biochem, New Haven, CT USA; Yale Univ, Dept Comp Sci, New Haven, CT, USA; Yale Univ, Program Computat Biol & Bioinformat, New Haven, CT, USA
Mardinoglu, Adil, 1982 (författare)
Chalmers tekniska högskola,Chalmers University of Technology,Kungliga Tekniska Högskolan (KTH),Royal Institute of Technology (KTH),KTH Royal Inst Technol, Sci Life Lab, Stockholm, Sweden; Chalmers Univ Technol, Dept Biol & Biol Engn, Gothenburg, Sweden
Smith, Ulf, 1943 (författare)
Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine,University of Gothenburg,Univ Gothenburg, Dept Mol & Clin Med, Gothenburg, Sweden
Rubin, D. L.(författare)
Pitteri, Sharon (författare)
Stanford University,Stanford Univ, Dept Radiol, Sch Med, Stanford, CA, USA; Stanford Univ, Canary Ctr Stanford, Sch Med, Stanford, CA, USA
Sodergren, Erica (författare)
The Jackson Laboratory for Genomic Medicine,Jackson Lab Genom Med, Farmington, CT, USA
McLaughlin, Tracey L. (författare)
Stanford University,Stanford Univ, Div Endocrinol, Sch Med, Stanford, CA, USA
Weinstrock, George M. (författare)
Jackson Lab Genom Med, Farmington, CT, USA
Snyder, Michael P. (författare)
Stanford University,Stanford Univ, Dept Genet, Sch Med, Stanford, CA, USA
Advances in omics technologies now allow an unprecedented level of phenotyping for human diseases, including obesity, in which individual responses to excess weight are heterogeneous and unpredictable. To aid the development of better understanding of these phenotypes, we performed a controlled longitudinal weight perturbation study combining multiple omics strategies (genomics, transcriptomics, multiple proteomics assays, metabolomics, and microbiomics) during periods of weight gain and loss in humans. Results demonstrated that: (1) weight gain is associated with the activation of strong inflammatory and hypertrophic cardiomyopathy signatures in blood; (2) although weight loss reverses some changes, a number of signatures persist, indicative of long-term physiologic changes; (3) we observed omics signatures associated with insulin resistance that may serve as novel diagnostics; (4) specific biomolecules were highly individualized and stable in response to perturbations, potentially representing stable personalized markers. Most data are available open access and serve as a valuable resource for the community.