Cardiac Troponin Testing in Patients with COVID-19: A Strategy for Testing and Reporting Results

BACKGROUND: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that emerged late in 2019 causing COVID-19 (coronavirus disease-2019) may adversely affect the cardiovascular system. Publications from Asia, Europe, and North America have identified cardiac troponin as an important prognostic indicator for patients hospitalized with COVID-19. We recognized from publications within the first 6 months of the pandemic that there has been much uncertainty on the reporting, interpretation, and pathophysiology of an increased cardiac troponin concentration in this setting. CONTENT: The purpose of this mini-review is: a) to review the pathophysiology of SARS-CoV-2 and the cardiovascular system, b) to overview the strengths and weaknesses of selected studies evaluating cardiac troponin in patients with COVID-19, and c) to recommend testing strategies in the acute period, in the convalescence period and in long-term care for patients who have become ill with COVID-19. SUMMARY: This review provides important educational information and identifies gaps in understanding the role of cardiac troponin and COVID-19. Future, properly designed studies will hopefully provide the much-needed evidence on the path forward in testing cardiac troponin in patients with COVID-19.

Hammarsten, OlaGothenburg University,Göteborgs universitet,Institutionen för biomedicin,Institute of Biomedicine(Swepub:gu)xhamol (författare)
Worster, A. (författare)
Smith, S. W. (författare)
Apple, F. S. (författare)
Göteborgs universitetInstitutionen för biomedicin (creator_code:org_t)

Ingår i:Clinical Chemistry: Oxford University Press (OUP)67:1, s. 107-1130009-91471530-8561

Av författaren/redakt...: Kavsak, P. A.; Hammarsten, Ola; Worster, A.; Smith, S. W.; Apple, F. S.

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