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Sökning: onr:"swepub:oai:gup.ub.gu.se/319094" > Estimating Analytic...

  • Ognissanti, DamianoGothenburg University,Göteborgs universitet,Institutionen för matematiska vetenskaper,Department of Mathematical Sciences,Chalmers tekniska högskola,Chalmers University of Technology,University of Gothenburg,Department of Mathematical Sciences, Chalmers University of Technology and University of Gothenburg, Gothenburg, Sweden.,Chalmers Univ Technol, Sweden; Univ Gothenburg, Sweden (författare)

Estimating Analytical Errors of Glomerular Filtration Rate Measurement

  • Artikel/kapitelEngelska2022

Förlag, utgivningsår, omfång ...

  • 2022-07-08
  • Oxford University Press (OUP),2022

Nummerbeteckningar

  • LIBRIS-ID:oai:gup.ub.gu.se/319094
  • https://gup.ub.gu.se/publication/319094URI
  • https://doi.org/10.1093/clinchem/hvac098DOI
  • https://research.chalmers.se/publication/531170URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-480331URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-187417URI

Kompletterande språkuppgifter

  • Språk:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Funding Agencies|Swedish Cancer Society; Heart and Lung Foundation; LUA/ALF funding at Sahlgrenska University Hospital; County Council of ostergotland
  • Background Few studies are available on how to optimize time points for sampling and how to estimate effects of analytical uncertainty when glomerular filtration rate (GFR) is calculated. Methods We explored the underlying regression mathematics of how analytical variation of a kidney filtration marker affects 1-compartment, slope-and-intercept GFR calculations, using 2 or 3 time points following a bolus injection, and used this to examine the results from 731 routine 3-point iohexol plasma clearance measurements. Results GFR calculations inflated analytical uncertainty if the time points were taken too late after the bolus injection and too close after each other. The uncertainty in GFR calculation was, however, the same as the analytical uncertainty if optimal time points were used. The middle of the 3 samples was of little value. The first sample should be taken as early as possible after the distribution phase. Sampling before the patient specific half-life of the kidney filtration marker resulted in an exponential error inflation whereas no error inflation was seen when sampling occurred later than 2 half-lives. Theoretical GFR uncertainty could be lowered 2.6-fold if individually optimized time points for sampling had been used in our 731 clearance measurements. Using Taylor expansions to approximate the moments of transformed random variables, the uncertainty of an individual GFR measurement could be calculated in a simple enough way to be applicable by laboratory software. Conclusions We provide a theoretical foundation to select patient-optimal time points that may both limit errors and allow calculation of GFR uncertainty.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Andresen Bergström, Moa,1978Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för laboratoriemedicin,Department of Laboratory Medicine,University of Gothenburg,Sahlgrenska universitetssjukhuset,Sahlgrenska University Hospital,Department of Clinical Chemistry, Sahlgrenska University Hospital, Gothenburg, Sweden.,Sahlgrens Univ Hosp, Sweden; Univ Gothenburg, Sweden(Swepub:gu)xanmoa (författare)
  • Theodorsson, ElvarLinköpings universitet,Avdelningen för klinisk kemi och farmakologi,Medicinska fakulteten,Region Östergötland, Klinisk kemi(Swepub:liu)elvth65 (författare)
  • Larsson, AndersUppsala universitet,Klinisk kemi,Uppsala Univ, Sweden(Swepub:uu)andlarss (författare)
  • Nordin, G.External Quality Assurance in Laboratory Medicine in Sweden (EQUALIS), Uppsala, Sweden.,External Qual Assurance Lab Med Sweden EQUALIS, Sweden (författare)
  • Hammarsten, OlaGothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för laboratoriemedicin,Department of Laboratory Medicine,Sahlgrenska universitetssjukhuset,Sahlgrenska University Hospital,University of Gothenburg,Department of Clinical Chemistry, Sahlgrenska University Hospital, Gothenburg, Sweden.,Sahlgrens Univ Hosp, Sweden; Univ Gothenburg, Sweden(Swepub:gu)xhamol (författare)
  • Göteborgs universitetInstitutionen för matematiska vetenskaper (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Clinical Chemistry: Oxford University Press (OUP)68:9, s. 1211-12180009-91471530-8561

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