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Sökning: onr:"swepub:oai:lup.lub.lu.se:088130d1-9113-4205-bd0b-d44e377ccc70" > Screening protocols...

Screening protocols to monitor respiratory status in primary immunodeficiency disease : findings from a European survey and subclinical infection working group

Jolles, S. (författare)
University Hospital of Wales
Sánchez-Ramón, S. (författare)
Hospital Clinico San Carlos de Madrid
Quinti, Isabella (författare)
Sapienza University of Rome
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Soler-Palacín, P. (författare)
Vall d'Hebron University Hospital
Agostini, C. (författare)
University of Padova
Florkin, B. (författare)
University of Liège Hospital
Couderc, L. J. (författare)
Versailles Saint-Quentin-en-Yvelines University
Brodszki, N. (författare)
Lund University,Lunds universitet,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital
Jones, A. (författare)
University College London
Longhurst, Hilary (författare)
Queen Mary University
Warnatz, Klaus (författare)
Albert-Ludwigs University Freiburg
Haerynck, F. (författare)
Ghent University Hospital
Matucci, A. (författare)
University of Florence
de Vries, Dick E. (författare)
Jeroen Bosch Hospital,Tilburg University
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 (creator_code:org_t)
British Society for Immunology, 2017
2017
Engelska 9 s.
Ingår i: Clinical and Experimental Immunology. - : British Society for Immunology. - 0009-9104. ; 190:2, s. 226-234
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • Many patients with primary immunodeficiency (PID) who have antibody deficiency develop progressive lung disease due to underlying subclinical infection and inflammation. To understand how these patients are monitored we conducted a retrospective survey based on patient records of 13 PID centres across Europe, regarding the care of 1061 adult and 178 paediatric patients with PID on immunoglobulin (Ig) G replacement. The most common diagnosis was common variable immunodeficiency in adults (75%) and hypogammaglobulinaemia in children (39%). The frequency of clinic visits varied both within and between centres: every 1–12 months for adult patients and every 3–6 months for paediatric patients. Patients diagnosed with lung diseases were more likely to receive pharmaceutical therapies and received a wider range of therapies than patients without lung disease. Variation existed between centres in the frequency with which some clinical and laboratory monitoring tests are performed, including exercise tests, laboratory testing for IgG subclass levels and specific antibodies, and lung function tests such as spirometry. Some tests were carried out more frequently in adults than in children, probably due to difficulties conducting these tests in younger children. The percentage of patients seen regularly by a chest physician, or who had microbiology tests performed following chest and sinus exacerbations, also varied widely between centres. Our survey revealed a great deal of variation across Europe in how frequently patients with PID visit the clinic and how frequently some monitoring tests are carried out. These results highlight the urgent need for consensus guidelines on how to monitor lung complications in PID patients.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine (hsv//eng)

Nyckelord

antibody deficiency
lung disease
monitoring
primary immunodeficiency disease
subclinical infection

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