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Sökning: onr:"swepub:oai:lup.lub.lu.se:0ed9bab1-cae4-4269-a606-390f5f859231" > Plasma Metabolome a...

Plasma Metabolome and Circulating Vitamins Stratified Onset Age of an Initial Islet Autoantibody and Progression to Type 1 Diabetes : the TEDDY Study

Li, Qian (författare)
University of South Florida; Department of Sociology,Farr Institute of Health Informatics Research,Shriners Hospitals for Children, Tampa,University of South Florida
Liu, Xiang (författare)
University of South Florida; Department of Sociology
Yang, Jimin (författare)
University of South Florida; Department of Sociology
visa fler...
Erlund, Iris (författare)
Finnish National Institute for Health and Welfare
Lernmark, Åke (författare)
Lund University,Lunds universitet,Diabetes och celiaki,Forskargrupper vid Lunds universitet,Diabetes and Celiac Unit,Lund University Research Groups
Hagopian, William (författare)
Pacific Northwest Diabetes Research Institute
Rewers, Marian (författare)
University of Colorado-Denver
She, Jin-Xiong (författare)
Augusta University
Toppari, Jorma (författare)
Turku University Hospital
Ziegler, Anette-G (författare)
Jalisco Institute of Diabetes and Obesity Research SC
Akolkar, Beena (författare)
National Institutes Of Health Clinical Center
Krischer, Jeffrey P (författare)
University of South Florida; Department of Sociology
visa färre...
 (creator_code:org_t)
 
American Diabetes Association Inc. 2021
2021
Engelska 11 s.
Ingår i: Diabetes. - : American Diabetes Association Inc.. - 1939-327X. ; 70:1, s. 282-292
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • Children's plasma metabolome, especially lipidome reflects gene regulation and dietary exposures, heralding the development of islet autoantibodies (IA) and type 1 diabetes (T1D). The TEDDY study enrolled 8676 newborns by screening HLA-DR-DQ genotypes at six clinical centers in four countries; profiled metabolome and measured concentrations of ascorbic acid, 25-hydroxyvitamin D (25(OH)D), erythrocyte membrane fatty acids following birth until IA seroconversion under nested case-control design. We grouped children having an initial autoantibody only against insulin (IAA-first) or glutamic acid decarboxylase (GADA-first) by unsupervised clustering of temporal lipidome, identifying a subgroup of children having early onset of each initial autoantibody, i.e., IAA-first by 12 months and GADA-first by 21 months, consistent with population-wide early seroconversion age. Differential analysis showed that infants having reduced plasma ascorbic acid and cholesterol experienced IAA-first earlier, while early onset of GADA-first was preceded by reduced sphingomyelins at infancy. Plasma 25(OH)D prior to either autoantibody was lower in T1D progressors compared to non-progressors, with simultaneous lower diglycerides, lysophosphatidylcholines, triglycerides, alanine before GADA-first. Plasma ascorbic acid and 25(OH)D at infancy were lower in HLA-DR3/DR4 children among IA cases but not in matched controls, implying gene expression dysregulation of circulating vitamins as latent signals for IA or T1D progression.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine (hsv//eng)

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