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Structural and micr...
Structural and microstructural thalamocortical network disruption in sporadic behavioural variant frontotemporal dementia
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- Jakabek, David (författare)
- Neuroscience Research Australia (NeuRA)
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- Power, Brian D. (författare)
- University of Notre Dame Australia
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- Spotorno, Nicola (författare)
- Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,LU profilområde: Proaktivt åldrande,Lunds universitets profilområden,Clinical Memory Research,Lund University Research Groups,LU Profile Area: Proactive Ageing,Lund University Profile areas
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- Macfarlane, Matthew D. (författare)
- Illawarra Shoalhaven Local Health District
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- Walterfang, Mark (författare)
- Royal Melbourne Hospital
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- Velakoulis, Dennis (författare)
- University of Melbourne
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- Nilsson, Christer (författare)
- Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups
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- Waldö, Maria Landqvist (författare)
- Lund University,Lunds universitet,Kliniska Vetenskaper, Helsingborg,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Clinical Sciences, Helsingborg,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Lätt, Jimmy (författare)
- Lund University,Lunds universitet,MR Physics,Forskargrupper vid Lunds universitet,Lund University Research Groups
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- Nilsson, Markus (författare)
- Lund University,Lunds universitet,Avdelningen för Bevarande och Digitalisering,Universitetsbiblioteket,Bibliotek,Department of Preservation and Digitisation,Lund University Library,Library
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- van Westen, Danielle (författare)
- Lund University,Lunds universitet,Neuroradiologi,Forskargrupper vid Lunds universitet,LU profilområde: Proaktivt åldrande,Lunds universitets profilområden,Neuroradiology,Lund University Research Groups,LU Profile Area: Proactive Ageing,Lund University Profile areas,Skåne University Hospital
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- Lindberg, Olof (författare)
- Karolinska Institutet,Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups
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- Looi, Jeffrey C.L. (författare)
- Australian National University
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- Santillo, Alexander F. (författare)
- Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,LU profilområde: Proaktivt åldrande,Lunds universitets profilområden,Clinical Memory Research,Lund University Research Groups,LU Profile Area: Proactive Ageing,Lund University Profile areas
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(creator_code:org_t)
- 2023
- 2023
- Engelska.
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Ingår i: NeuroImage: Clinical. - 2213-1582. ; 39, s. 1-11
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Background: Using multi-block methods we combined multimodal neuroimaging metrics of thalamic morphology, thalamic white matter tract diffusion metrics, and cortical thickness to examine changes in behavioural variant frontotemporal dementia. (bvFTD). Method: Twenty-three patients with sporadic bvFTD and 24 healthy controls underwent structural and diffusion MRI scans. Clinical severity was assessed using the Clinical Dementia Rating scale and behavioural severity using the Frontal Behaviour Inventory by patient caregivers. Thalamic volumes were manually segmented. Anterior and posterior thalamic radiation fractional anisotropy and mean diffusivity were extracted using Tract-Based Spatial Statistics. Finally, cortical thickness was assessed using Freesurfer. We used shape analyses, diffusion measures, and cortical thickness as features in sparse multi-block partial least squares (PLS) discriminatory analyses to classify participants within bvFTD or healthy control groups. Sparsity was tuned with five-fold cross-validation repeated 10 times. Final model fit was assessed using permutation testing. Additionally, sparse multi-block PLS was used to examine associations between imaging features and measures of dementia severity. Results: Bilateral anterior-dorsal thalamic atrophy, reduction in mean diffusivity of thalamic projections, and frontotemporal cortical thinning, were the main features predicting bvFTD group membership. The model had a sensitivity of 96%, specificity of 68%, and was statistically significant using permutation testing (p = 0.012). For measures of dementia severity, we found similar involvement of regional thalamic and cortical areas as in discrimination analyses, although more extensive thalamo-cortical white matter metric changes. Conclusions: Using multimodal neuroimaging, we demonstrate combined structural network dysfunction of anterior cortical regions, cortical-thalamic projections, and anterior thalamic regions in sporadic bvFTD.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)
Nyckelord
- Behavioural variant frontotemporal dementia
- Diffusion
- MRI
- Partial least squares
- Shape analysis
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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- Av författaren/redakt...
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Jakabek, David
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Power, Brian D.
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Spotorno, Nicola
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Macfarlane, Matt ...
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Walterfang, Mark
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Velakoulis, Denn ...
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Nilsson, Christe ...
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Waldö, Maria Lan ...
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Lätt, Jimmy
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Nilsson, Markus
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van Westen, Dani ...
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Lindberg, Olof
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Looi, Jeffrey C. ...
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Santillo, Alexan ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Radiologi och bi ...
- Artiklar i publikationen
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NeuroImage: Clin ...
- Av lärosätet
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Lunds universitet
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Karolinska Institutet