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Sökning: onr:"swepub:oai:lup.lub.lu.se:41462d29-a6eb-4576-a976-cf4652e5ca77" > FTO genotype and we...

FTO genotype and weight loss : systematic review and meta-analysis of 9563 individual participant data from eight randomised controlled trials

Livingstone, Katherine M. (författare)
University of Newcastle
Celis-Morales, Carlos (författare)
University of Glasgow
Papandonatos, George D (författare)
Brown University
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Erar, Bahar (författare)
Brown University
Florez, Jose C. (författare)
Broad Institute
Jablonski, Kathleen A. (författare)
University of Washington
Razquin, Cristina (författare)
University of Navarra
Marti, Amelia (författare)
University of Navarra
Heianza, Yoriko (författare)
Tulane University
Huang, Tao (författare)
National University of Singapore
Sacks, Frank M (författare)
Harvard University
Svendstrup, Mathilde (författare)
University of Copenhagen
Sui, Xuemei (författare)
University of South Carolina
Church, Timothy S. (författare)
Pennington Biomedical Research Center
Jääskeläinen, Tiina (författare)
University of Eastern Finland
Lindström, Jaana (författare)
Finnish National Institute for Health and Welfare
Tuomilehto, Jaakko (författare)
King Abdulaziz University
Uusitupa, Matti (författare)
University of Eastern Finland
Rankinen, Tuomo (författare)
Pennington Biomedical Research Center
Saris, Wim H M (författare)
Maastricht University
Hansen, Torben (författare)
University of Copenhagen
Pedersen, Oluf (författare)
University of Copenhagen
Astrup, Arne (författare)
University of Copenhagen
Sørensen, Thorkild I A (författare)
University of Copenhagen
Qi, Lu (författare)
Harvard University
Bray, George A (författare)
Pennington Biomedical Research Center
Martinez-Gonzalez, Miguel A. (författare)
University of Navarra
Martinez, J Alfredo (författare)
University of Navarra
Franks, Paul W. (författare)
Lund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups,Harvard Medical School,Skåne University Hospital
McCaffery, Jeanne M (författare)
Brown University
Lara, Jose (författare)
University of Newcastle upon Tyne
Mathers, John C. (författare)
University of Newcastle upon Tyne
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 (creator_code:org_t)
BMJ Publishing Group, 2016
2016
Engelska.
Ingår i: BMJ: British Medical Journal. - : BMJ Publishing Group. - 1756-1833. ; 354
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • OBJECTIVE: To assess the effect of the FTO genotype on weight loss after dietary, physical activity, or drug based interventions in randomised controlled trials.DESIGN: Systematic review and random effects meta-analysis of individual participant data from randomised controlled trials.DATA SOURCES: Ovid Medline, Scopus, Embase, and Cochrane from inception to November 2015.ELIGIBILITY CRITERIA FOR STUDY SELECTION: Randomised controlled trials in overweight or obese adults reporting reduction in body mass index, body weight, or waist circumference by FTO genotype (rs9939609 or a proxy) after dietary, physical activity, or drug based interventions. Gene by treatment interaction models were fitted to individual participant data from all studies included in this review, using allele dose coding for genetic effects and a common set of covariates. Study level interactions were combined using random effect models. Metaregression and subgroup analysis were used to assess sources of study heterogeneity.RESULTS: We identified eight eligible randomised controlled trials for the systematic review and meta-analysis (n=9563). Overall, differential changes in body mass index, body weight, and waist circumference in response to weight loss intervention were not significantly different between FTO genotypes. Sensitivity analyses indicated that differential changes in body mass index, body weight, and waist circumference by FTO genotype did not differ by intervention type, intervention length, ethnicity, sample size, sex, and baseline body mass index and age category.CONCLUSIONS: We have observed that carriage of the FTO minor allele was not associated with differential change in adiposity after weight loss interventions. These findings show that individuals carrying the minor allele respond equally well to dietary, physical activity, or drug based weight loss interventions and thus genetic predisposition to obesity associated with the FTO minor allele can be at least partly counteracted through such interventions.SYSTEMATIC REVIEW REGISTRATION: PROSPERO CRD42015015969.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Hälsovetenskap -- Näringslära (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Hälsovetenskaper (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Health Sciences (hsv//eng)

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