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Sökning: onr:"swepub:oai:lup.lub.lu.se:d1ca89b2-77bf-48eb-9596-66b352d16ef9" > Persistent organic ...

Persistent organic pollutants and the size of ovarian reserve in reproductive-aged women

Björvang, Richelle D. (författare)
Karolinska Institutet,Karolinska University Hospital
Hassan, Jasmin (författare)
Karolinska Institutet,Karolinska University Hospital
Stefopoulou, Maria (författare)
Karolinska Institutet,Karolinska University Hospital
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Gemzell-Danielsson, Kristina (författare)
Karolinska Institutet,Karolinska University Hospital
Pedrelli, Matteo (författare)
Karolinska Institutet
Kiviranta, Hannu (författare)
Finnish National Institute for Health and Welfare
Rantakokko, Panu (författare)
Finnish National Institute for Health and Welfare
Ruokojärvi, Päivi (författare)
Finnish National Institute for Health and Welfare
Lindh, Christian H. (författare)
Lund University,Lunds universitet,Avdelningen för arbets- och miljömedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Tillämpad masspektrometri inom miljömedicin,Forskargrupper vid Lunds universitet,Division of Occupational and Environmental Medicine, Lund University,Department of Laboratory Medicine,Faculty of Medicine,Applied Mass Spectrometry in Environmental Medicine,Lund University Research Groups
Acharya, Ganesh (författare)
Karolinska Institutet,Karolinska University Hospital
Damdimopoulou, Pauliina (författare)
Karolinska Institutet,Karolinska University Hospital
Lindh, CH (författare)
Damdimopoulou, P (författare)
Karolinska Institutet
Kiviranta, H (författare)
Acharya, G (författare)
Björvang, RD (författare)
Ruokojärvi, P (författare)
Stefopoulou, M (författare)
Pedrelli, M (författare)
Karolinska Institutet
Hassan, J (författare)
Rantakokko, P (författare)
Gemzell-Danielsson, K (författare)
Karolinska Institutet
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 (creator_code:org_t)
Elsevier, 2021
2021
Engelska.
Ingår i: Environment International. - : Elsevier. - 0160-4120 .- 1873-6750. ; 155
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • Industrial chemicals such as persistent organic pollutants (POPs) have been associated with reduced fertility in women, including longer time-to-pregnancy (TTP), higher odds for infertility, and earlier reproductive senescence. Fertility is highly dependent on the ovarian reserve, which is composed of a prenatally determined stock of non-growing follicles. The quantity and quality of the follicles decline with age, thereby eventually leading to menopause. In the clinical setting, assessing ovarian reserve directly through the histological analysis of follicular density in ovaries is not practical. Therefore, surrogate markers of ovarian reserve, such as serum anti-Müllerian hormone (AMH) are typically used. Here, we studied associations between chemical exposure and ovarian reserve in a cohort of pregnant women undergoing elective caesarean section (n = 145) in Stockholm, Sweden. Full data (histological, clinical, serum) were available for 50 women. We estimated the size of the reserve both directly by determining the density of follicles in ovarian cortical tissue samples, and indirectly by measuring AMH in associated serum samples. Concentrations of 9 organochlorine pesticides (OCPs), 10 polychlorinated biphenyls (PCBs), 3 polybrominated diphenylethers (PBDEs) and 9 perfluoroalkyl substances (PFAS) were determined in serum, and clinical data were retrieved from electronic medical records. Healthy follicle densities (median 0, range 0–193 follicles/mm3) and AMH levels (median 2.33 ng/mL, range 0.1–14.8 ng/mL) varied substantially. AMH correlated with the density of growing follicles. Twenty-three chemicals detected in more than half of the samples were included in the analyses. None of the chemicals, alone or as a mixture, correlated with AMH, growing or atretic follicles. However, HCB, transnonachlor, PCBs 74 and 99 were associated with decreased non-growing follicle densities. HCB and transnonachlor were also negatively associated with healthy follicle density. Further, mixture of lipophilic POPs (PBDE 99, p,p’-DDE, and PCB 187) was associated with lower non-growing follicle densities. In addition, exposure to HCB, p,p’-DDE, and mixture of OCPs were significantly associated with higher odds of infertility. The results suggest that exposure to chemicals may reduce the size of ovarian reserve in humans, and strongly encourage to study mechanisms behind POP-associated infertility in women in more detail.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Obstetrics, Gynecology and Reproductive Medicine (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Hälsovetenskap -- Arbetsmedicin och miljömedicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Health Sciences -- Environmental Health and Occupational Health (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin (hsv//swe)
MEDICIN OCH HÄLSOVETENSKAP  -- Hälsovetenskaper (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine (hsv//eng)
MEDICAL AND HEALTH SCIENCES  -- Health Sciences (hsv//eng)

Nyckelord

Anti-Müllerian hormone
Female fertility
Ovarian reserve
Ovary
Persistent organic pollutants

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